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GDF15 is a cytokine well known for its anorectic effect on systemic energy metabolism. GDF15 expression and secretion from various organs and tissues are induced in a variety of physiological and pathophysiological states, often linked to mitochondrial stress, resulting in highly variable GDF15 levels in the bloodstream. Because GDF15 can be inducibly produced and secreted in response to strenuous exercise or acute myocardial infarction, it is classified as a myokine and cardiokine. GDF15 regulates hematopoietic development, energy balance, adipose tissue metabolism, body growth, bone remodeling, and stress response. GDF15 plays a pleiotropic role in obesity, tumorigenesis, metastasis, immunomodulation, and cachexia.The recombinant GDF15 antibody is a monoclonal antibody molecule expressed by using recombinant DNA and protein engineering technology to clone the genes encoding the GDF15 antibody into a plasma vector and then by transfecting the vector clone into the appropriate recipient mammalian cells for production. It was purified using Affinity-chromatography. And it shows reactivity with GDF15 protein from Human. This recombinant GDF15 antibody can be used in the ELISA, IHC.
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