CASP1

Caspase-1, also called interleukin-1β converting enzyme (ICE), is a cysteine-aspartic protease central to inflammatory responses. It cleaves pro-IL-1β and pro-IL-18 into active cytokines and triggers pyroptosis via gasdermin D cleavage, mediating pro-inflammatory cell death.
Regulated by inflammasomes like NLRP3 and AIM2, its dysregulation links to autoinflammatory disorders (e.g., CAPS) and neurodegenerative diseases such as Alzheimer’s. Inhibitors like VX-765 are under clinical trials for CAPS, reducing cytokine levels and symptom severity, showing promise as anti-inflammatory therapeutics.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CASP1 Antibody (CSB-PA05824A0Rb)

Validated Data

Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA05824A0Rb at dilution of 1:100

Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA05824A0Rb at dilution of 1:100

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA05824A0Rb at dilution of 1:100

Human Caspase 1(Casp-1) ELISA Kit (CSB-E13025h)

Validated Data

Code: CSB-E13025h

Size: 96T,5×96T,10×96T

Sensitivity: 0.39 ng/ml

Detection Range: 1.56 ng/ml - 100 ng/ml

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following CASP1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

CASP1 Antibodies

CASP1 Proteins

CASP1 ELISA Kits

CASP1 Antibodies

CASP1 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA05824A0Rb	CASP1 Antibody	Human	ELISA, IHC
CSB-PA05824B0Rb	CASP1 Antibody, HRP conjugated	Human	ELISA
CSB-PA001227	CASP1 Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA060245	Cleaved-CASP1 (D210) Antibody	Human	WB, IHC, ELISA
CSB-PA060246	Cleaved-CASP1 (M211) Antibody	Human	IHC, ELISA
CSB-PA060247	CASP1 Antibody	Human,Monkey	WB, ELISA
CSB-PA060248	Cleaved-CASP1 (N120) Antibody	Human	WB, ELISA
CSB-PA060249	Phospho-CASP1 (S376) Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA758068	CASP1 Antibody	Human	ELISA,WB,IHC
CSB-PA05829A0Rb	CASP1 Antibody	Human	ELISA, IHC, IF
CSB-PA05829B0Rb	CASP1 Antibody, HRP conjugated	Human	ELISA
CSB-PA05829C0Rb	CASP1 Antibody, FITC conjugated	Human
CSB-PA05829D0Rb	CASP1 Antibody, Biotin conjugated	Human	ELISA

CASP1 Antibodies for Arabidopsis thaliana (Mouse-ear cress)

Code	Product Name	Species Reactivity	Application
CSB-PA874426XA01DOA	CASP1 Antibody	Arabidopsis thaliana	ELISA, WB (ensure identification of antigen)

CASP1 Proteins

CASP1 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP004543RA CSB-EP004543RA CSB-BP004543RA CSB-MP004543RA CSB-EP004543RA-B	Recombinant Rat Caspase-1 (Casp1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CASP1 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP004543HU CSB-EP004543HU CSB-BP004543HU CSB-MP004543HU CSB-EP004543HU-B	Recombinant Human Caspase-1 (CASP1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-RP058244h	Recombinant Human Caspase-1 (CASP1), partial	E.coli
CSB-EP004543HU1	Recombinant Human Caspase-1 (CASP1), partial	E.coli
CSB-EP004543HU2	Recombinant Human Caspase-1 (CASP1), partial	E.coli
CSB-EP004543HU2-B	Recombinant Human Caspase-1 (CASP1), partial, Biotinylated	E.coli

CASP1 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP004543MO CSB-EP004543MO CSB-BP004543MO CSB-MP004543MO CSB-EP004543MO-B	Recombinant Mouse Caspase-1 (Casp1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CASP1 Proteins for Felis catus (Cat) (Felis silvestris catus)

Code	Product Name	Source
CSB-YP868220CA CSB-EP868220CA CSB-BP868220CA CSB-MP868220CA CSB-EP868220CA-B	Recombinant Cat Caspase-1 (CASP1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CASP1 Proteins for Equus caballus (Horse)

Code	Product Name	Source
CSB-YP874691HO CSB-EP874691HO CSB-BP874691HO CSB-MP874691HO CSB-EP874691HO-B	Recombinant Horse Caspase-1 (CASP1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CASP1 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

Code	Product Name	Source
CSB-YP882005DO CSB-EP882005DO CSB-BP882005DO CSB-MP882005DO CSB-EP882005DO-B	Recombinant Dog Caspase-1 (CASP1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CASP1 Proteins for Sus scrofa (Pig)

Code	Product Name	Source
CSB-YP889025PI CSB-BP889025PI CSB-MP889025PI CSB-EP889025PI-B	Recombinant Pig Caspase-1 (CASP1), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CASP1 Proteins for Arabidopsis thaliana (Mouse-ear cress)

Code	Product Name	Source
CSB-CF874426DOA	Recombinant Arabidopsis thaliana Casparian strip membrane protein 1 (CASP1)	in vitro E.coli expression system
CSB-YP874426DOA1 CSB-EP874426DOA1 CSB-BP874426DOA1 CSB-MP874426DOA1 CSB-EP874426DOA1-B	Recombinant Arabidopsis thaliana Casparian strip membrane protein 1 (CASP1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CASP1 ELISA Kit

CASP1 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-E13025h	Human Caspase 1(Casp-1) ELISA Kit	serum, plasma, tissue homogenates	0.39 ng/ml

CASP1 ELISA Kit for Rattus norvegicus (Rat)

Code	Product Name	Sample Types	Sensitivity
CSB-EL004543RA	Rat Caspase-1(CASP1) ELISA kit	serum, plasma, cell lysates, cell culture supernates	1.56 pg/mL

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