DAXX

Death domain-associated protein 6 is a protein in humans that is encoded by DAXX gene. Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity.

DAXX Antibodies

DAXX Antibodies for Homo sapiens (Human)

DAXX Proteins

DAXX Proteins for Mus musculus (Mouse)

DAXX Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)

DAXX Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

DAXX Proteins for Rattus norvegicus (Rat)

DAXX Proteins for Homo sapiens (Human)

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