GSK3B Research Reagents

Glycogen synthase kinase-3 beta is a protein in humans that is encoded by GSK3B gene. Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase.

The following GSK3B reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

GSK3B Antibodies

GSK3B Antibodies for Homo sapiens (Human)

GSK3B Proteins

GSK3B Proteins for Rattus norvegicus (Rat)

GSK3B Proteins for Homo sapiens (Human)

GSK3B Proteins for Spermophilus citellus (European suslik) (Citellus citellus)

GSK3B Proteins for Xenopus laevis (African clawed frog)

GSK3B Proteins for Mus musculus (Mouse)

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