Phospho-GSK3B (Ser9) Antibody

Datasheet
Code CSB-PA166926
Size US$360
Image
  • Western blot analysis of extracts from 293 cells untreated(lane 1) or treated with serum(lane 2) using GSK3β(Phospho-Ser9) Antibody.
  • Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using GSK3β (Phospho-Ser9) Antibody (left) or the same antibody preincubated with blocking peptide (right).
  • Immunofluorescence staining of methanol-fixed Hela cells showing cytoplasmic staining using GSK3β(Phospho-Ser9) Antibody.
  • Immunohistochemical analysis of paraffin-embedded human Lung carcinoma tissue using GSK3β (Phospho-Ser9) Antibody.
  • Immunofluorescence staining of methanol-fixed Hela cells showing cytoplasmic staining using GSK3β (Phospho-Ser9) Antibody.
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) GSK3B Polyclonal antibody
Uniprot No. P49841
Target Names GSK3B
Alternative Names Glycogen Synthase Kinase 3 Beta antibody; Glycogen synthase kinase-3 beta antibody; GSK 3 beta antibody; GSK-3 beta antibody; GSK3B antibody; GSK3B_HUMAN antibody; GSK3beta isoform antibody; Serine/threonine-protein kinase GSK3B antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Peptide sequence around phosphorylation site of serine 9 (T-T-S(p)-F-A) derived from Human GSK3β.
Immunogen Species Homo sapiens (Human)
Clonality Polyclonal
Purification Method Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Concentration It differs from different batches. Please contact us to confirm it.
Form Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications ELISA,WB,IHC,IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:1000
IHC 1:50-1:100
IF 1:100-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Citations

Distinct dual roles of p-Tyr42 RhoA GTPase in tau phosphorylation and ATP citrate lyase activation upon different Aβ concentrations. KC Cap,Redox Biology,2020

Applications: Western blotting
Sample type: HT22 cells
Review: HT22 cells were pretreated with Tat-C3 (1 μg/ml) for 1 h, and then treated with fAβ (1 μM or 10 μM) for 24 h, and then several proteins related to the several proteins likely related to the Aβ signalling pathway were assessed by western blotting with each specific antibody
PMID: 32046944

Target Data

Function Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules. MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the establishment of neuronal polarity and axon outgrowth. Phosphorylates MARK2, leading to inhibit its activity. Phosphorylates SIK1 at 'Thr-182', leading to sustain its activity. Phosphorylates ZC3HAV1 which enhances its antiviral activity. Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation. Phosphorylates SFPQ at 'Thr-687' upon T-cell activation. Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including ARNTL/BMAL1, CLOCK and PER2. Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation. Phosphorylates ARNTL/BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation. Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity. Phosphorylates MYCN in neuroblastoma cells which may promote its degradation
Gene References into Functions
  1. our study suggests that GSK3B plays a pivotal role in HCV virion assembly and release mediated in part through inhibition of apolipoprotein synthesis PMID: 28566716
  2. The results demonstrated that 2HF could inhibit EMT, and cell migration and invasion through the Wnt/bcatenin signaling pathway by suppressing GSK3b phosphorylation, betacatenin expression and transactivation. PMID: 30226607
  3. Results show that SK3beta modulates NF-kappaB activation and RelB degradation through phosphorylation of BCL10 providing evidence for a novel regulatory mechanism by which GSK3beta affects NF-kappaB signaling in activated T cells. PMID: 29358699
  4. LINC00222 acts as a tumor suppressor in lung adenocarcinoma, regulating GSK3beta activity to promote tumor cell apoptosis. PMID: 29990868
  5. miR-199b attenuated the inflammatory response at least partly through the GSK3beta/NF-kappaB signaling pathways in monocytes PMID: 29779167
  6. The luciferase reporter system studies affirmed the direct regulation of miR-452 on the 3'-UTR of the GSK3b, which activate the Wnt/b-catenin signaling. The ectopic upregulation of miR-452 significantly inhibited the expression of GSK3b and enhanced colorectal cancer (CRC) proliferation and invasion in vitro and in vivo. PMID: 30253791
  7. Results show GSK-3beta as a direct target of miR-377-3p and its expression is inversely correlated with that of miR-377 in colorectal cancer cells. PMID: 28857252
  8. Data show that glycogen synthase kinase 3 (GSK3) and proto-oncogene proteins B-raf (BRAF)/MAPK signaling converges to control microphthalmia-associated transcription factor MITF (MITF) nuclear export. PMID: 30150413
  9. GSK-3beta expression is associated with non-small cell lung cancer differentiation and GSK-3beta inhibits autophagy and enhances the radiosensitivity of non-small cell lung cancer cells PMID: 29793508
  10. Its signaling pathway regulates phosphorylated tau accumulation in brain of stressed condition. PMID: 29656013
  11. these results indicate that miR124 transection inhibits the growth and aggressive of osteosarcoma, potentially via suppression of TGFbetamediated AKT/GSK3beta/snail family transcriptional repressor 1 (SNAIL1) signaling, suggesting miR124 may be a potential anticancer agent/target for osteosarcoma therapy. PMID: 29488603
  12. miR-150 was upregulated in CNE-2R cells and played roles in radioresistance in CNE-2 cells. Meanwhile, we found that miR-150 directly targeted GSK3beta gene, and radioresistance in CNE-2R cells could be significantly reversed with ectopic GSK3beta expression. PMID: 29516971
  13. As shown in xenograft model of glioblastoma phosphorylation of 53BP1 by GSK3beta was indispensable for DNA double-strand break repair. PMID: 29328365
  14. miR-1301-3p promoted the expansion of prostate cancer stem cells by inhibiting GSK3beta and SFRP1, and activating the Wnt pathway. PMID: 29358129
  15. MMP-9 overexpression and activation are important events occurring during oral squamous cell carcinoma progression/invasion and that this overexpression/activation is regulated by c-Myc, active MMP-2 and inactive GSK3beta mediated pathways. PMID: 29134466
  16. High GSK3B expression is associated with cervical cancer tumorigenesis and metastasis. PMID: 28627610
  17. GSK-3beta activation index is a potential indicator for recurrent inflammation of chronic rhinosinusitis without nasal polyps. PMID: 28714566
  18. our results revealed that Livin induced EMT through the activation of the p38/GSK3beta pathway, which in turn promoted the progression and metastasis of breast cancer, especially for triple-negative breast cancer (TNBC) PMID: 29039608
  19. Findings showed that NOS1AP (rs348624, rs12742393 and rs1415263), DISC1 (rs821633 and rs1000731), DAOA (rs2391191) and GSK3B (rs6438552) SNPs had no association with development of early-onset schizophrenia; however, our finding suggested statistically significant role of the interaction of NOS1AP, DISC1, DAOA and GSK3B polymorphisms in schizophrenia susceptibility. PMID: 29100974
  20. GSK3beta-SKAP-Kif2b signaling axis constitutes a dynamic link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division. PMID: 27982129
  21. Casein kinase II, glycogen synthase kinase-3, and Ikaros mediated regulation of leukemia has been summarized. (Review) PMID: 28623166
  22. GSK-3 signaling in health and disease has been discussed. (Review) PMID: 28705437
  23. GSK3 interacts with the PI3K/AKT/mTOR signaling network via phosphorylation. (Review) PMID: 28712664
  24. The data suggested that mediators of the Wnt signalling pathway, such as GSK3beta could be important therapeutic targets for early-stage Osteonecrosis of the femoral head. PMID: 29136173
  25. GSK-3beta is critically important for ordered NF-kappaB signalling through modulation of NEMO phosphorylation. PMID: 27929056
  26. GSK-3 is a novel prognostic indicator in leukemia. (Review) PMID: 28499784
  27. GSK3beta may inhibit VRK2 catalytic activity by disrupting its flexibility. The inhibition of VRK2 catalytic activity by GSK3beta may also inhibit VRK2-induced degradation of TRiC, which could suppress polyQ-expanded Htt aggregation. PMID: 27377031
  28. Mast cells deplete stemness features of glioma cells and induce differentiation. Mast cells exert their effect via inactivation of STAT3 through GSK3 beta downregulation. PMID: 28600192
  29. In conclusion, the authors demonstrated that AKT activation prevents apoptosis, partly through inhibition of GSK3beta, resulting in pluripotent stem cells survival. PMID: 27762303
  30. Downregulation of miR-125b regulates apoptosis in human NSCLC through the suppression of the PI3K/Akt/GSK3beta and Wnt/beta-catenin signaling pathways. PMID: 28713974
  31. This study found that GSK3beta mRNA was overexpressed only in patients with initial Alzheimer's Disease, with no effect on the levels of the protein. PMID: 28176663
  32. We demonstrated the activation of GSK-3beta in classical Hodgkin lymphomas resulting in inhibition of the Wnt/beta-catenin signal cascade and the aberrant accumulation of its activated form in nuclei of Hodgkin Reed-Sternberg and Hodgkin cells PMID: 28208230
  33. CB2 activation with sub-micromolar doses of agonists, which could be more similar to endogenous levels of cannabinoids, promote colon cancer progression in a process that involves AKT and GSK3beta. PMID: 27634891
  34. An imbalanced regulation in protein kinases and protein phosphatases is the direct cause of tau hyperphosphorylation in Alzheimer's disease; GSK-3beta and PP2A are the most implicated. (Review) PMID: 28585125
  35. In this review, we have opted to focus on GSK3beta interactions with mitochondria in ischemic heart disease and expand on the therapeutic interventions. PMID: 28421373
  36. axonal impairment in temporal lobe epilepsy may be mediated by NMDAR via GSK-3beta and Cdk5. In addition, inhibiting either NMDARs or GSK-3beta lowered the relative tau phosphorylation level by reversing the decrease of total tau without affecting phosphorylated tau S396 and T231. PMID: 28595035
  37. GSK-3beta was overexpressed in endometrial cancer tissues, and was positively correlated with International Federation of Gynecology and Obstetrics (FIGO) staging, dedifferentiation, and myometrial infiltration depth; GSK-3beta overexpression predicted lower cumulative and relapse-free survival rate PMID: 27050373
  38. WM130 preferentially inhibits hepatic cancer stem-like cells by suppressing AKT/GSK3beta/beta-catenin signaling pathway. PMID: 27783993
  39. MicroRNA-101 reverses temozolomide resistance by inhibition of GSK3beta expression in glioblastoma cells. PMID: 27792996
  40. Gankyrin sustains PI3K/GSK-3beta/beta-catenin signal activation and promotes an aggressive colorectal cancer phenotype and disease progression. PMID: 27835604
  41. Study sows that expression of the active form of GSK- 3beta (tyrosine 216-phosphorylated) was higher in osteosarcoma than osteoblast cells, and demonstrated a critical role for GSK-3beta in sustaining survival and proliferation of osteosarcoma cells. PMID: 27780915
  42. 14-3-3zeta and aPKC-iota synergistically facilitate EMT of cholangiocarcinoma via GSK-3beta/Snail signalling pathway. PMID: 27409422
  43. Results indicate that hypoxia increases IL-11 secretion in anaplastic thyroid carcinoma (ATC) cells via HIF-1alpha induction and that IL-11 then induces epithelial-mesenchymal transition (EMT) in these cells via the PI3K/Akt/GSK3beta pathway. PMID: 27487122
  44. High GSK3B expression is associated with drug resistance in breast cancer. PMID: 26895471
  45. Oncogenic miR-19a and miR-19b were up-regulated in lung cancer stem cells which modulated cancer cells activity. miR-19 activated Wnt/beta-catenin pathway via directly targeting Glycogen Synthase Kinase 3 beta. Sulforaphane suppressed lung cancer stem cells through down-regulating miR-19 and inhibiting Wnt/beta-catenin pathway activation. PMID: 28431267
  46. ZIP9 expression affects phosphorylation states of GSK-3beta. PMID: 27654922
  47. High GSK3 expression is associated with prostate cancer. PMID: 26871944
  48. Cytoplasmic aryl hydrocarbon receptor regulates glycogen synthase kinase 3 beta in non-small cell lung cancer cells. PMID: 27752740
  49. ablation of Glut1 attenuated apoptosis and increased drug resistance via upregulation of p-Akt/p-GSK-3beta (Ser9)/beta-catenin/survivin. PMID: 28803837
  50. frequent upregulation of MIF is implicated in the development and progression of esophageal squamous cell carcinoma (ESCC). PMID: 29079416
  51. TRIM9s undergoes Lys-63-linked auto-polyubiquitination and serves as a platform to bridge GSK3beta to TBK1, leading to the activation of IRF3 signaling. PMID: 26915459
  52. Data suggest that NOX5 expression in melanoma cells could contribute to cell proliferation due, in part, to the generation of high local concentrations of extracellular ROS that modulate multiple pathways that regulate HIF-1alpha and networks that signal through Akt/GSK3beta/p27(Kip1) . PMID: 28762556
  53. Our findings support our a priori hypothesis of a possible interaction between GSK3B (rs12630592 T allele) and FXR1 (rs496250 A allele) in mood disorder patients. PMID: 28242499
  54. Data indicate that DET1- and DDB1-associated protein 1 (DDA1)-mediated tumor progression is associated with the activation of the NF-kappa B (NFkappaB)/COP9 signalosome 2(CSN2)/glycogen synthase kinase3beta (GSK3beta) pathway. PMID: 26942699
  55. Results indicate that AQP3 promotes stem-like properties of gastric carcinoma (GC) cells by activating the Wnt/GSK-3beta/beta-catenin signaling pathway. PMID: 26918728
  56. increasing basal autophagy and AMPK activity by inhibiting GSK3b may be an effective strategy in the setting of hyperglycaemia and dyslipidaemia for restoring endothelial cell health and reducing atherogenesis. PMID: 27534430
  57. Our results reveal a new mechanism of ZNF322A oncoprotein destruction regulated by the CK1delta/GSK3beta/FBXW7a axis. Deregulation of this signaling axis results in ZNF322A overexpression and promotes cancer progression PMID: 28581525
  58. The present work identified GSK-3beta as a new interacting protein for D1R functional regulation and revealed a novel mechanism for GSK-3beta-regulated D1R function which may underlie D1R dysfunction in schizophrenia. PMID: 27996211
  59. The ovarian cancer cell lines BG-1 and UCI-101 were transfected with the let-7 reporter and surveyed with a library of kinase inhibitors in order to identify pathways affecting let-7 activity. Among the inhibitors causing changes in endogenous let-7 abundance, the lowering of GSK-3beta function specifically increased let-7 levels and lowered luciferase activity. PMID: 23840442
  60. Taken together, this study reveals evidence demonstrating a mechanism by which the LPR6/ GSK3beta/E2F1 axis-upregulated LSH promoted gliomas. PMID: 28042322
  61. High GSK3B expression is associated with glioblastoma. PMID: 28423558
  62. AKT/GSK-3beta-mediated stabilization of SP1 is required for TGF-beta induced up-regulation of NKG2DLs. PMID: 28165192
  63. These findings reveal that Endoplasmic reticulum stress engages the GSK3beta-TIP60-ULK1 pathway to increase autophagy. PMID: 28032867
  64. The data indicate that the AC023115.3-miR-26a-GSK3beta signaling axis plays an important role in reducing the chemoresistance of glioma. PMID: 28499919
  65. Results demonstrated that expression of total GSK3beta is significantly high in the cancer tissues of esophageal squamous cell carcinoma (ESCC) patients but the phosphorylated form is decreased in cancer tissues. Also, the study found that inhibition of either GSK3beta or STAT3 alone resulted in a significant decrease in ESCC cell viability and migration, indicating their contribution to the malignancy phenotype. PMID: 28574599
  66. our findings identify the miR-410/Gsk3beta/beta-catenin signaling axis is a novel molecular circuit in inducing stemness of non-small cells lung cancer PMID: 28076327
  67. NOR1 suppresses cancer stem-like cell properties in nasopharyngeal carcinoma cells by inhibiting the AKT-GSK-3beta-Wnt/beta-catenin-ALDH1A1 signaling circuit. PMID: 27891591
  68. Studies show strong evidence supporting the idea that the hyperactive nutrient sensor GSK3beta plays a pivotal role in preserving quiescent hematopoietic stem cells despite its negative effects on self-renewal. [review] PMID: 27538509
  69. BMI1 is a downstream target of GSK3 signaling. PMID: 27100571
  70. These findings suggest that the upregulation of Snail expression induced by H. pylori and transformation to a spindle-like shape as a consequence in gastric cancer cells are attributable to reactive oxygen species - mediated activation of Erk and the inactivation of GSK-3beta. PMID: 26808296
  71. changes in GSK-3beta activity and/or levels regulate the production and subsequent secretion of fractalkine, a chemokine involved in the immune response that has been linked to AD and to other different neurological disorders. PMID: 27832289
  72. Data indicate that microRNA miR-27a directly targets GSK-3beta and increases expression of beta-catenin and LEF1 in all-trans-retinoic acid (ATRA)-induced Hep2 cells. PMID: 28122350
  73. Data indicate that microRNA miR-744 activated Wnt/beta-catenin pathway by targeting multiple negative regulators of Wnt/beta-catenin signaling, including SFRP1, GSK3beta, TLE3 and NKD1, and that NKD1 is a major functional target of miR-744. PMID: 28107193
  74. this study shows that cross-talk between LFA-1 and Notch1 through the Akt/ERK-GSK3beta signaling enhances T cell differentiation toward Th1 PMID: 27206767
  75. SGK1 promotes YAP/TAZ transcriptional activity. SGK1 enhances YAP/TAZ activity by upregulating YAP/TAZ. SGK1 is a transcriptional target of YAP. SGK1 stabilizes TAZ by inhibiting GSK3beta. PMID: 28634071
  76. Inhibition of GSK3 and TGF-beta1 signaling resulted in promotion of epithelial transition of human adipose mesenchymal stem cells. PMID: 28698144
  77. Results demonstrated that GSK3b may phosphorylate CDX2 in its phosphodegron motifs leading to its degradation by Fbw7. PMID: 27470268
  78. Data show that growth differentiation factor 15 (GDF15) knockdown significantly inhibited the growth and metastasis of cancer stem-like sphere cells (SCs) through AKT/GSK-3beta/beta-catenin pathway suppression. PMID: 28199981
  79. We initially observed that p-Akt, p-GSK-3b, and b-catenin were overexpressed in a series of advanced gastric adenocarcinoma specimens and found that the Akt and Wnt pathways were correlated with gastric tumorigenesis. we showed that the PI3K/Akt and Wnt/beta-catenin signaling pathways promoted EMT by epigenetically activating the expression of Twist in gastric cancer. PMID: 28671020
  80. Inhibition of GSK-3 is a promising therapeutic approach to overcome chemoresistance in human breast cancer. PMID: 27424289
  81. High GSK3B expression is associated with colorectal cancer. PMID: 27599658
  82. High GSK3B expression is associated with hepatoma. PMID: 28112375
  83. These findings suggest that SGK2 promotes hepatocellular carcinoma progression and mediates glycogen synthase kinase 3 beta/b-catenin signaling in hepatocellular carcinoma cells PMID: 28639896
  84. p-PTEN, Akt, p-PDK1, and p-GSK-3beta were significantly downregulated after the knockdown of CK2alpha expression. PMID: 28442011
  85. Findings suggest that synapse-associated protein of 97-kDa molecular weight and disrupted in schizophrenia 1 contribute to maintaining Wnt/beta-catenin signaling activity within a homeostatic range by regulating glycogen synthase kinase 3 beta phosphorylation. PMID: 27026592
  86. Results indicate a mechanism of beta-arrestin1 in modulating epithelial-mesenchymal transition (EMT) and glycogen synthase kinase 3 beta (GSK-3beta)/beta-catenin signaling in prostate cancer, and suggest that assessment of beta-arrestin1 may provide a potential therapeutic target for prostate cancer. PMID: 27620488
  87. Bufalin induced cell apoptosis in H1975 cells may be through downregulation of Mcl-1. Proteasomal degradation of Mcl-1 via GSK-3beta activation was involved in bufalin-induced apoptosis. PMID: 28419994
  88. Results indicated that phosphorylation of glycogen synthase kinase 3beta at Ser9 might be involved in Human endogenous retrovirus W family envelope (HERV-W env)-induced brain-derived neurotrophic factor expression, and will hopefully improve our understanding of the role of HERV-W env in neurological and psychiatric diseases (schizophrenia, etc). PMID: 27235578
  89. PKCalpha-GSK3beta-NF-kappaB signaling pathway involvement in TRAIL-induced apoptosis PMID: 27219672
  90. Gsk3beta and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease PMID: 27503909
  91. the signaling pathway study confirmed that Sox9 protected MRC-5 from lipopolysaccharide injury through the AKT/GSK3beta pathway. PMID: 28601070
  92. identified FBXO17 as an F-box protein subunit that recognizes and mediates GSK3beta polyubiquitination. PMID: 28298444
  93. GSK3beta attenuates TGF-beta1 induced epithelial-mesenchymal transition and metabolic alterations in retinal pigment epithelial cells. PMID: 28342867
  94. Data show that the truncation promotes glycogen synthase kinase-3beta (GSK-3beta) nuclear translocation and enhances its interaction with protein phosphatase 2A (PP2A), leading to dephosphorylation. PMID: 28267204
  95. that nuclear GSK3beta- and USP22-mediated KDM1A stabilization is essential for glioblastoma tumorigenesis PMID: 27501329
  96. conclusion, serum leptin was elevated in CKD patients and it might contribute to endothelial dysfunction by disarrangement of f-actin cytoskeleton via a mechanism involving the AKT/GSK3beta and beta-catenin pathway. PMID: 27789284
  97. The aim of the study was to determine the possible role of glycogen synthase kinase 3beta (GSK-3beta) and nuclear factor kappa beta (NFKB) as prognostic variables in pediatric patients with Acute lymphocytic leukemia. PMID: 28028966
  98. findings highlight an essential compartmentalization of both PKA and GSK3beta by GSKIP, and ascribe a function to a cytosolic AKAP-PKA interaction as a regulatory factor in the control of canonical Wnt signaling. PMID: 27484798
  99. In conclusion, the present study revealed for the first time that miR-199b-5p plays a positive role in osteoblast differentiation. PMID: 27363340
  100. These findings demonstrate the posttranslational regulation of Foxp3 expression by AREG in cancer patients through AREG/EGFR/GSK-3beta signaling, which could lead to Foxp3 protein degradation in Treg cells and a potential therapeutic target for cancer treatment. PMID: 27432879

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Subcellular Location Cytoplasm, Nucleus, Cell membrane
Protein Families Protein kinase superfamily, CMGC Ser/Thr protein kinase family, GSK-3 subfamily
Tissue Specificity Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney. Colocalizes with EIF2AK2/PKR and TAU in the Alzheimer disease (AD) brain.
Database Links

HGNC: 4617

OMIM: 605004

KEGG: hsa:2932

STRING: 9606.ENSP00000324806

UniGene: Hs.445733

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