MET is a gene providing an instruction of making a protein named hepatocyte growth factor receptor (also known as c-Met). After HGF specifically binds to the c-Met, it induces a change in the conformation of the c-Met, and activates the protein tyrosine kinases PTK in the intracellular protein kinase domain of the receptor. The activated PTK phosphorylates the receptor's own tyrosine residue, resulting in phosphorylation of various substrate proteins, such as phospholipase (PLCγ) and phosphatidylinositol-3-kinase (PI3K), resulting in the activation of downstream signaling pathways. The signal is amplified step by step, and finally transferred to the transcription mechanism in the nucleus, which regulates various processes such as cell proliferation, differentiation, contraction, movement, secretion and division.
HGF/c-Met signaling system plays an important role in tumor cell proliferation, angiogenesis, infiltration and metastasis by activating multiple signaling pathways in cells Inhibiting the proliferation and metastasis of tumor cells can be used as one of the strategies for anti-tumor infiltration and metastasis therapy.
Recombinant Human Hepatocyte growth factor receptor(MET),partial (Active) (CSB-MP013714HU)
Validated Data
Greater than 90% as determined by SDS-PAGE.
Immobilized MET at 2 μg/ml can bind Anti-MET recombinant antibody, the EC50 is 2.379-3.094 ng/ml.
The following met reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
met Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA013714GA01HU | MET Antibody |
Human,Mouse,Rat | ELISA,WB |
CSB-PA890092 | Phospho-MET (Tyr1234) Antibody |
Human,Mouse,Rat | ELISA,WB |
CSB-PA446172 | Phospho-MET (Tyr1349) Antibody |
Human,Mouse,Rat | ELISA,WB |
CSB-PA267782 | MET (Ab-154) Antibody |
Human,Mouse,Rat | ELISA,WB |
CSB-PA562889 | MET (Ab-1003) Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA933202 | MET Antibody |
Human,Mouse,Rat | ELISA, WB, IF |
CSB-PA832684 | Phospho-MET (Tyr1003) Antibody |
Human,Mouse,Rat | ELISA,WB |
CSB-PA988938 | MET (Ab-1003) Antibody |
Human,Mouse,Rat | ELISA,WB,IHC,IF |
CSB-PA955702 | MET (Ab-1234) Antibody |
Human,Mouse,Rat | ELISA,WB |
CSB-PA080821 | MET (Ab-1313) Antibody |
Human,Mouse,Rat | ELISA,WB |
CSB-PA000574 | Phospho-MET (Y1234) Antibody |
Human,Mouse,Rat,Monkey | WB, ELISA |
CSB-PA000575 | Phospho-MET (Y1349) Antibody |
Human,Mouse,Rat | WB, ELISA |
CSB-PA003231 | MET Antibody |
Human | WB, ELISA |
CSB-PA003232 | MET Antibody |
Human,Mouse,Rat | WB, IF, ELISA |
CSB-PA003233 | MET Antibody |
Human,Mouse,Rat | WB, IF, ELISA |
CSB-PA010181 | Phospho-MET (Y1356) Antibody |
Human,Mouse,Rat | WB, ELISA |
CSB-PA010182 | Phospho-MET (Y1003) Antibody |
Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA010183 | MET Antibody |
Human | IF, ELISA |
CSB-PA010184 | MET Antibody |
Human,Mouse,Rat | WB, ELISA |
CSB-PA063357 | MET Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA694564 | MET Antibody |
Human,Mouse,Rat | ELISA,IHC |
CSB-PA376125 | MET Antibody |
Human,Mouse,Rat | IHC,ELISA |
CSB-PA013714LA01HU | MET Antibody |
Human | ELISA, IHC, IF |
CSB-PA013714LB01HU | MET Antibody, HRP conjugated |
Human | ELISA |
CSB-PA013714LC01HU | MET Antibody, FITC conjugated |
Human | |
CSB-PA013714LD01HU | MET Antibody, Biotin conjugated |
Human | ELISA |
CSB-RA983271A0HU | MET Recombinant Monoclonal Antibody |
Human | ELISA, WB, IHC, IF, FC |
CSB-RA634199A0HU | MET Recombinant Monoclonal Antibody |
Human | ELISA, IHC |
met Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP013714MO CSB-EP013714MO CSB-BP013714MO CSB-MP013714MO CSB-EP013714MO-B |
Recombinant Mouse Hepatocyte growth factor receptor (Met), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
met Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP013714HU CSB-EP013714HU CSB-BP013714HU CSB-EP013714HU-B |
Recombinant Human Hepatocyte growth factor receptor (MET), partial |
Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
CSB-EP013714HU1(M) | Recombinant Human Hepatocyte growth factor receptor (MET) (N375S), partial |
E.coli |
CSB-EP013714HU1 | Recombinant Human Hepatocyte growth factor receptor (MET), partial |
E.coli |
CSB-AP003691HU | Recombinant Human Hepatocyte growth factor receptor (MET), partial (Active) |
Mammalian cell |
CSB-MP013714HU | Recombinant Human Hepatocyte growth factor receptor (MET), partial (Active) |
Mammalian cell |
met Proteins for Felis catus (Cat) (Felis silvestris catus)
Code | Product Name | Source |
---|---|---|
CSB-YP013714CA CSB-EP013714CA CSB-BP013714CA CSB-MP013714CA CSB-EP013714CA-B |
Recombinant Cat Hepatocyte growth factor receptor (MET), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
met Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP013714RA CSB-EP013714RA CSB-BP013714RA CSB-MP013714RA CSB-EP013714RA-B |
Recombinant Rat Hepatocyte growth factor receptor (Met), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
met Proteins for Papio anubis (Olive baboon)
Code | Product Name | Source |
---|---|---|
CSB-YP013714ERI CSB-EP013714ERI CSB-BP013714ERI CSB-MP013714ERI CSB-EP013714ERI-B |
Recombinant Papio anubis Hepatocyte growth factor receptor (MET), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
met Proteins for Echinops telfairi (Lesser hedgehog tenrec)
Code | Product Name | Source |
---|---|---|
CSB-YP013714EJK CSB-EP013714EJK CSB-BP013714EJK CSB-MP013714EJK CSB-EP013714EJK-B |
Recombinant Echinops telfairi Hepatocyte growth factor receptor (MET), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
met Proteins for Ovis aries (Sheep)
Code | Product Name | Source |
---|---|---|
CSB-YP600726SH CSB-EP600726SH CSB-BP600726SH CSB-MP600726SH CSB-EP600726SH-B |
Recombinant Sheep Hepatocyte growth factor receptor (MET), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
met Proteins for Loxodonta africana (African elephant)
Code | Product Name | Source |
---|---|---|
CSB-YP608846LJC CSB-EP608846LJC CSB-BP608846LJC CSB-MP608846LJC CSB-EP608846LJC-B |
Recombinant Loxodonta africana Hepatocyte growth factor receptor (MET), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
met Proteins for Rhinolophus ferrumequinum (Greater horseshoe bat)
Code | Product Name | Source |
---|---|---|
CSB-YP641335RKD CSB-EP641335RKD CSB-BP641335RKD CSB-MP641335RKD CSB-EP641335RKD-B |
Recombinant Rhinolophus ferrumequinum Hepatocyte growth factor receptor (MET), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
met Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Code | Product Name | Source |
---|---|---|
CSB-YP641336PYX CSB-EP641336PYX CSB-BP641336PYX CSB-MP641336PYX CSB-EP641336PYX-B |
Recombinant Pongo abelii Hepatocyte growth factor receptor (MET), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
met Proteins for Gorilla gorilla gorilla (Western lowland gorilla)
Code | Product Name | Source |
---|---|---|
CSB-YP641337GGZ CSB-EP641337GGZ CSB-BP641337GGZ CSB-MP641337GGZ CSB-EP641337GGZ-B |
Recombinant Gorilla gorilla gorilla Hepatocyte growth factor receptor (MET), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
met Proteins for Eulemur macaco macaco (Black lemur)
Code | Product Name | Source |
---|---|---|
CSB-YP642260EPG CSB-EP642260EPG CSB-BP642260EPG CSB-MP642260EPG CSB-EP642260EPG-B |
Recombinant Eulemur macaco macaco Hepatocyte growth factor receptor (MET), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
met Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
Code | Product Name | Source |
---|---|---|
CSB-YP645340DSU CSB-EP645340DSU CSB-BP645340DSU CSB-MP645340DSU CSB-EP645340DSU-B |
Recombinant Chlorocebus aethiops Hepatocyte growth factor receptor (MET), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
met Proteins for Microcebus murinus (Lesser mouse lemur) (Gray Mouse Lemur)
Code | Product Name | Source |
---|---|---|
CSB-YP647700MFU CSB-EP647700MFU CSB-BP647700MFU CSB-MP647700MFU CSB-EP647700MFU-B |
Recombinant Microcebus murinus Hepatocyte growth factor receptor (MET), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
met Proteins for Plecturocebus moloch (Dusky titi monkey) (Callicebus moloch)
Code | Product Name | Source |
---|---|---|
CSB-YP647703CYE CSB-EP647703CYE CSB-BP647703CYE CSB-MP647703CYE CSB-EP647703CYE-B |
Recombinant Callicebus moloch Hepatocyte growth factor receptor (MET), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
met Proteins for Pan troglodytes (Chimpanzee)
Code | Product Name | Source |
---|---|---|
CSB-YP647705EQV CSB-EP647705EQV CSB-BP647705EQV CSB-MP647705EQV CSB-EP647705EQV-B |
Recombinant Pan troglodytes Hepatocyte growth factor receptor (MET), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
met Proteins for Equus caballus (Horse)
Code | Product Name | Source |
---|---|---|
CSB-YP650068HO CSB-EP650068HO CSB-BP650068HO CSB-MP650068HO CSB-EP650068HO-B |
Recombinant Horse Hepatocyte growth factor receptor (MET), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
met Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-YP651633PI CSB-EP651633PI CSB-BP651633PI CSB-MP651633PI CSB-EP651633PI-B |
Recombinant Pig Hepatocyte growth factor receptor (MET), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
met Proteins for Callithrix jacchus (White-tufted-ear marmoset)
Code | Product Name | Source |
---|---|---|
CSB-YP651635CYL CSB-EP651635CYL CSB-BP651635CYL CSB-MP651635CYL CSB-EP651635CYL-B |
Recombinant Callithrix jacchus Hepatocyte growth factor receptor (MET), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
met Proteins for Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)
Code | Product Name | Source |
---|---|---|
CSB-YP651636OFS CSB-EP651636OFS CSB-BP651636OFS CSB-MP651636OFS CSB-EP651636OFS-B |
Recombinant Otolemur garnettii Hepatocyte growth factor receptor (MET), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
met Proteins for Plectranthus scutellarioides (Coleus) (Solenostemon scutellarioides)
Code | Product Name | Source |
---|---|---|
CSB-YP674836SAAH CSB-EP674836SAAH CSB-BP674836SAAH CSB-MP674836SAAH CSB-EP674836SAAH-B |
Recombinant Solenostemon scutellarioides 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (MET), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
met Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP758830BO CSB-EP758830BO CSB-BP758830BO CSB-MP758830BO CSB-EP758830BO-B |
Recombinant Bovine Hepatocyte growth factor receptor (MET), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
met Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
Code | Product Name | Source |
---|---|---|
CSB-YP762310DO CSB-EP762310DO CSB-BP762310DO CSB-MP762310DO CSB-EP762310DO-B |
Recombinant Dog Hepatocyte growth factor receptor (MET), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
met ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E13490h | Human hepatocyte growth factor receptor(c-MET/HGFR)ELISA Kit |
serum, plasma, tissue homogenates | 7.8 pg/mL |
met ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E13492m | Mouse Hepatocyte Growth Factor Receptor(C-MET/HGFR)ELISA Kit |
serum, plasma, tissue homogenates | 0.02 ng/mL |