Mouse Hepatocyte Growth Factor Receptor(C-MET/HGFR)ELISA Kit

Instructions
Code CSB-E13492m
Size 96T,5×96T,10×96T
See More Details 24T ELISA kits trial application
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Product Details

Target Name met proto-oncogene (hepatocyte growth factor receptor)
Alternative Names Met ELISA Kit; Hepatocyte growth factor receptor ELISA Kit; HGF receptor ELISA Kit; EC 2.7.10.1 ELISA Kit; HGF/SF receptor ELISA Kit; Proto-oncogene c-Met ELISA Kit; Scatter factor receptor ELISA Kit; SF receptor ELISA Kit; Tyrosine-protein kinase Met ELISA Kit
Abbreviation MET
Uniprot No. P16056
Species Mus musculus (Mouse)
Sample Types serum, plasma, tissue homogenates
Detection Range 0.078 ng/mL-5 ng/mL
Sensitivity 0.02 ng/mL
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Cancer
Troubleshooting
and FAQs
ELISA kit FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 3-5 working days

Target Data

Function Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells (By similarity). May regulate cortical bone osteogenesis
Involvement in disease Activation of Met after rearrangement with the TPR (translocated promoter) locus of chromosome 1 produces an oncogenic protein.
Subcellular Location Membrane, Single-pass type I membrane protein
Protein Families Protein kinase superfamily, Tyr protein kinase family
Database Links

STRING: 10090.ENSMUSP00000079324

UniGene: Mm.86844

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