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| Code | CSB-AP003151MO |
| Product Type | Colony Stimulating Factor |
| Size |
US$112Purchase it in Cusabio online store (only available for customers from the US) |
| Uniprot No. | P20826 |
| Lead Time | 5-10 business days |
| Image | |
| Storage Buffer | 0.2 μm filtered PBS, pH 7.4 ,lyophilized |
| Alias | Hematopoietic growth factor KL, MGF, Steel factor, Stem cell factor, SCF |
| Species | Mus musculus (Mouse) |
| Biological_Activity | Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 10 ng/ml, corresponding to a specific activity of >1.0x105 IU/mg. |
| Purity | >97% as determined by SDS-PAGE and HPLC. |
| Endotoxin | Less than 1.0 EU/μg as determined by LAL method. |
| Sequence | M+KEICGNPVT DNVKDITKLV ANLPNDYMIT LNYVAGMDVL PSHCWLRDMV IQLSLSLTTL LDKFSNISEG LSNYSIIDKL GKIVDDLVLC MEENAPKNIK ESPKRPETRS FTPEEFFSIF NRSIDAFKDF MVASDTSDCV LSSTLGPEKD SRVSVTKPFM LPPVA |
| Research Area | Immunology |
| Source | E.coli |
| Gene Names | Kitlg |
| Expression Region | 26-189aa |
| Tag Info | Tag-Free |
| Mol. Weight | 18.4 kDa |
| Protein Description | Partial |
| PubMed ID | 1698558; 1378327; 1705866; 1383087; 8849898; 8875893; 9360640; 16141072; 15489334; 1698557; 1698556; 1698554; 1698553; 17255936 |
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| Function | Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. |
| Subcellular Location | Isoform 1: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 2: Cytoplasm, Cytoplasm, cytoskeleton, Cell membrane, Single-pass type I membrane protein, Cytoplasm, cytoskeleton, Cell projection, lamellipodium, Cell projection, filopodium, SUBCELLULAR LOCATION: Soluble KIT ligand: Secreted |
| Protein Families | SCF family |
| Tissue Specificity | Expressed in the cochlea. |
| Database Links |
KEGG: mmu:17311 STRING: 10090.ENSMUSP00000100920 UniGene: Mm.45124 |
| Pathway |
MAPK signaling pathway
Melanogenesis PI3K-Akt signaling pathway Ras signaling pathway Fc gamma R-mediated phagocytosis Phospholipase D signaling pathway Rap1 signaling pathway |
Kitlg Proteins for Mus musculus (Mouse)
| Code | Product Name | Source |
|---|---|---|
| CSB-AP004071MO | Recombinant Mouse Kit ligand(Kitlg),partial | E.coli |
| CSB-CF012376MO | Recombinant Mouse Kit ligand(Kitlg) | in vitro E.coli expression system |
| CSB-YP012376MO1 CSB-EP012376MO1 CSB-BP012376MO1 CSB-MP012376MO1 |
Recombinant Mouse Kit ligand(Kitlg),partial | Yeast E.coli Baculovirus Mammalian cell |
Kitlg ELISA Kit for Mus musculus (Mouse)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E04719m | Mouse Stem cell factor/mast cell growth factor,SCF/MGF ELISA kit | serum, plasma, tissue homogenates | 0.78 pg/mL |
Recombinant Mpuse T-cell surface glycoprotein CD3 epsilon chain(Cd3e),partial
Express system: Yeast
Species: Mus musculus (Mouse)
Recombinant Human Hydroxymethylglutaryl-CoA lyase, mitochondrial(HMGCL)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Mouse Asialoglycoprotein receptor 2 (Asgr2),partial
Express system: E.coli
Species: Mus musculus (Mouse)
Recombinant Human Proteasome subunit beta type-8(PSMB8)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Macrophage mannose receptor 1(MRC1),partial
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Transcription activator BRG1(SMARCA4),partial
Express system: Yeast
Species: Homo sapiens (Human)
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