cam-1 Antibody

Datasheet

Code	CSB-PA219120XA01CXY
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans cam-1 Polyclonal antibody

Uniprot No.

G5EGK5

Target Names

cam-1

Alternative Names

cam-1 antibody; kin-8 antibody; C01G6.8Tyrosine-protein kinase receptor cam-1 antibody; EC 2.7.10.1 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans cam-1 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Tyrosine-protein kinase receptor for Wnt ligands egl-20, mom-2 and cwn-1. Involved in the final positioning of migrating ALM, CAN, BDU and HSN neurons during development. Involved in the anterior-posterior migration of QR neuroblast descendants, QR.p and QR.pa, by maintaining QR.p cell polarization, probably through mig-2. In addition, plays a role in ASI sensory neuron positioning and functions. Regulates asymmetric division of V cells (seam cells) and CA/CP neuroblast, and axon outgrowth. Probably by acting as a receptor for Wnt ligand cwn-2, plays a role in the positioning of the nerve ring by controlling axon guidance of SIA and SIB neurons. Involved in synapse plasticity by regulating delivery and/or stabilization of acetylcholine receptor acr-16 at post-synaptic membrane sites and the distribution of synaptic vesicles at pre-synaptic release sites. Probably by acting as a receptor for Wnt ligands cwn-1 and cwn-2, negatively regulates developmental neurite pruning of AIM neurons. Plays a role in ALM neuron polarity. By binding Wnt ligands mom-2, cwn-1 and egl-20 and thereby restricting their availability, negatively regulates Wnt signaling. This mechanism is involved in HSN neuron and QR neuronal descendent migration, and in vulva development. Involved in dauer formation, locomotion, tail morphology and egg-laying. May be involved in distal tip cell (DTC) migration during the development of the posterior gonad.; Involved in the positioning of the nerve ring.; Involved in the positioning of the nerve ring.

Gene References into Functions

SAX-3 binds to Wnt/CWN-2 and facilitates the membrane recruitment of CWN-2. SAX-3 forms a complex with the Ror/CAM-1 receptor and its downstream effector Dsh/DSH-1. PMID: 29463707
CAM-1 does not function exclusively as a canonical RTK and that it may function, at least in part, to regulate the distribution of a secreted ligand-possibly a Wnt protein. PMID: 14651925
CAM-1 negatively regulates EGL-20 PMID: 15371357
CAM-1 extracellular domain binds to several Wnts in vitro and non-autonomously inhibits the Wnt pathway. PMID: 17942487
The developmental survival of specific neurites in Caenorhabditis elegans largely depends on detection of the morphogen Wnt by the Ror kinase CAM-1. PMID: 19561603
Cell-specific rescue of cam-1 and cell ablation experiments reveal a crucial role for the SIA and SIB neurons in positioning the nerve ring, linking Wnt signaling to specific cells that organize the anterior nervous system. PMID: 19855022

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Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite. Perikaryon. Cell junction, synapse.; [Isoform b]: Cell membrane; Single-pass type I membrane protein. Cell projection, axon.

Protein Families

Protein kinase superfamily, Tyr protein kinase family, ROR subfamily

Tissue Specificity

Expressed in AIM neurons and in several head neurons. Isoform a is expressed in some head muscles and in several head neurons. Isoform b is expressed in several head neurons, in procorpus and isthmus pharyngeal muscles, body wall muscles, and to a lower e

Database Links

KEGG: cel:CELE_C01G6.8

STRING: 6239.C01G6.8a

UniGene: Cel.18279

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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