Recombinant Mouse Tumor necrosis factor receptor superfamily member 4(Tnfrsf4),partial (Active)

1. Crucial role of OX40/OX40L signaling in a murine model of asthma has been demonstrated. PMID: 29344664
2. Combination therapies that depend on checkpoint inhibitor antibodies (Abs) such as for PD-1 or its ligand (PD-L1) together with immune stimulatory agonist Abs like anti-OX40 are being tested in the clinic to achieve improved antitumor effects PMID: 28848055
3. High Fat Diet-induced obese mice exhibit increased OX40 expression in adipose tissues and splenic T cells. PMID: 28612217
4. These data support the hypothesis that the Ox40/Ox40L pathway drives cellular and humoral autoimmune responses during lupus nephritis in NZB/W F1 mice and emphasize the potential clinical value of targeting this pathway in human lupus. PMID: 28696253
5. OX40 is a death receptor for invariant natural killer T cells and is implicated in pyroptotic cell death. PMID: 28436935
6. this study shows that OX40 links a costimulatory receptor to a repressive chromatin remodeling pathway, and that that OX40 stimulation inhibits IL-17 and reduces experimental autoimmune encephalomyelitis PMID: 27317259
7. IFNalphaR1 signaling promoted CXCL9 and CXCL10 synthesis, suggesting that these chemokines might be involved in the LPS and CD134 costimulation response. PMID: 28432083
8. OX40 and ICOS act in a cooperative, nonredundant manner to maximize and prolong the T follicular helper cell response that is generated after acute virus infection PMID: 27895177
9. OX40 regulates cardiac remodelling via the modulation of CD4(+) T-lymphocytes. PMID: 27580926
10. bone marrow-derived mast cell (BMMC)-exosomes facilitated the differentiation of naive CD4+ T cells to Th2 cells by ligation of OX40L and OX40 between BMMC-exosomes and CD4+ T cells and represents a novel mechanism of cell-to-cell communication PMID: 27066504
11. Crystal structures and NMR data show that the Roquin-1 ROQ domain recognizes hexaloops in the SELEX-derived alternative decay element (ADE) and in an ADE-like variant present in the Ox40 3'-UTR with identical binding modes. PMID: 27010430
12. The OX40-OX40 ligand interaction up-regulates intracellular levels of reactive oxygen species in atherogenesis. PMID: 25115246
13. OX40 was highly expressed by intratumoral T cells, particularly those of the FoxP3(+) regulatory T-cell (Treg) lineage. PMID: 24732076
14. OX40 and IL-7 play synergistic, but distinct roles in the homeostatic proliferation of CD4(+) effector memory T cells PMID: 25103720
15. OX40-OX40L interaction regulates the expression of NFATc1, which may play a critical role in atherosclerotic plaque formation, and may therefore have implications with pathophysiology of atherosclerosis. PMID: 24045961
16. OX40 stimulation of virus-specific CD4 T cells promoted expression of the transcriptional repressor Blimp-1 and diverted the majority of cells away from follicular Th cell differentiation. PMID: 24101548
17. interruption of the OX40-OX40L signaling pathway, with decreases in dietary cholesterol, induces regression of atherosclerosis by induction of IL-5-producing T cells and oxidized low-density lipoprotein-specific IgM and reductions in Th2 and mast cells. PMID: 24068673
18. OX40-OX40L interaction promotes proliferation and activation of lymphocytes via NFATc1 in ApoE-deficient mice. PMID: 23593329
19. These data show that OX40-OX40L signaling contributes to the evolution of the adaptive immune response to an allograft via the differential control of alloreactive effector and regulatory T cell survival. PMID: 23817421
20. These results suggest that OX40 costimulation crucially engages survivin during antigen-mediated Th2 responses PMID: 23616302
21. mediates responsiveness to respiratory syncytial virus in neonates PMID: 23036746
22. OX40 facilitates control of a persistent virus infection. PMID: 22969431
23. Mechanistically, OX40 activated the ubiquitin ligase TRAF6, which triggered induction of the kinase NIK in CD4( ) T cells and the noncanonical transcription factor NF-kappaB pathway; this subsequently led to the generation of T(H)9 cells. PMID: 22842344
24. Both TNFRSF4 and TNFRSF25 independently and additively costimulate vaccine-induced CD8+ T cell proliferation following both primary and secondary antigen challenge. PMID: 22956587
25. OX40 (CD134), after ligation by OX40L, assembles a unique complex that not only contains TRAF2, RIP, and IKKalpha/beta/gamma but also CARMA1, MALT1, BCL10, and PKC, molecules previously shown to regulate NF-kappaB activation through the T-cell receptor (TCR). PMID: 21282629
26. OX40-OX40L interaction can regulate the mRNA and protein expressions of NFATc1 in lymphocytes of ApoE-/- mice. PMID: 21924079
27. Development of skin lesions was rather more likely explained by deletion of Ikbk2 in skin keratinocytes in OX40(Cre) mice. PMID: 22363815
28. following OX40 stimulation, blockade of Treg-cell suppression and enhancement of the Tem-cell adjuvant effect both concurred to free DCs from immunosuppression and activate the immune response against the tumor. PMID: 22229156
29. OX40L and PD-L2 expressed on dendritic cells differentially regulate cytokine production during recall responses in the lung. PMID: 22266281
30. OX40 engagement in vivo in naive mice induces initial expansion of Foxp3+ regulatory T (Treg) cells, but the expanded Tregs have poor suppressive function and exhibit features of exhaustion which can be prevented by exogenous interleukin (IL)-2. PMID: 22147766
31. sOX40 inhibits MC degranulation, it may provide an in vivo therapeutic tool in allergic disease. PMID: 21653238
32. Mxd4 and Mnt upregulation following OX40 engagement most likely increases T-cell survival PMID: 21400495
33. The vascular OX40/OX40L system plays an important role in the formation of vasa vasorum and subsequent atherosclerosis PMID: 20584752
34. Activation of OX40 augments Th17 cell function and thereby contributes to ocular inflammation. PMID: 20952591
35. OX40 is a key factor in shaping Treg sensitivity to IL-2 and promoting cell proliferation and survival. PMID: 20806292
36. OX40 on not only CD4(+) T cells but also NKT cells is involved in allergic airway inflammation. PMID: 20019337
37. OX40 plays a key role in the homeostasis of intestinal Foxp3+ T regulatory cells and in suppression of colitis. PMID: 20368580
38. find that OX40, a marker of both T cell activation and memory, is selectively upregulated in the brain during ECM and its distribution among CD4(+) and CD8(+) T cells accumulated in the brain vasculature is approximately equal PMID: 19710907
39. role in activation of CD8(+) intraepithelial lymphocytes PMID: 11739485
40. Engagement of OX40 enhances antigen-specific CD4(+) T cell mobilization/memory development and humoral immunity PMID: 11739496
41. Dendritic cell-induced CD4+ and CD8+ T cell responses in vivo are strongly amplified when Ox40 signaling is provided through an anti-Ox40 monoclonal antibody. PMID: 11777959
42. Constitutive interaction of OX40 with its ligand provides a system that plays a potential key role in the immune regulation of various autoimmune diseases. PMID: 12370402
43. relative importance of CD134 (OX40) and CD137 (4-1BB) in the costimulation of CD4+ and CD8+ T cells under comparable conditions of antigenic stimulation PMID: 12516549
44. The OX40/OX40L pathway has a broad importance in graft-versus-host disease induction. PMID: 12521997
45. T-cell stimulation via OX40 engagement during cryptococcosis infection using OX40L fusion protein (OX40L:Ig) promotes cell-mediated immunity and IFN-gamma production by CD4+ T cells, and reduces pathogen burden in the lung and associated eosinophilia. PMID: 12794142
46. expressed on memory CD4 cells; OX40-OX40L interactions are pivotal to the efficiency of recall responses regulated by memory Th2 cells PMID: 12860930
47. Interactions mediated by CD134 affect onset and development of experimental allergic encephalomyelitis; Cd134-/- mice show less severe clinical signs of disease and markedly reduced inflammatory infiltrates within the central nervous system. PMID: 14644025
48. OX40 signals may play a key role in mediating skin allograft rejection in CD28/CD154 double knockout mice. PMID: 14734751
49. Important roles are revealed for OX40 signals in regulatory T (Treg) cell development, homeostasis, and suppressive activity, showing how OX40 signals can oppose Treg mediated suppression when they are delivered directly to antigen-engaged naive T cells. PMID: 15004159
50. OX40 is one of the costimulatory molecules that can contribute signals to regulate the accumulation of antigen-reactive CD8 cells during immune responses. PMID: 15067059
51. costimulatory signal through OX40 allows otherwise harmless, proliferating, autoreactive T cells to acquire effector cell functions. PMID: 15153490
52. OX40/OX40L interactions form a late checkpoint in diabetes development and are realistic targets for therapeutic intervention. PMID: 15368274
53. CD134 blockade may be of therapeutic value in helping to prevent allograft rejection. PMID: 15385798
54. OX40 is expressed on different T cell subsets or at different times in vivo and acts independently and nonredundantly to promote robust CD4 T cell secondary responses. PMID: 15528328
55. in addition to controlling memory T-cell numbers, OX40 directly controls T reg-mediated suppression. PMID: 15591118
56. During CD4 T cell priming on dendritic cells (DCs), early OX40-signals act as a check on T cell proliferation while T cells integrate additional signals from DCs. PMID: 15661901
57. Administration of multiple immunizations in combination with the costimulatory agonist anti-OX40 enhanced the immune responses, resulting in complete tumor rejection if the tumor burden. PMID: 15856473
58. Survivin is controlled in peripheral T cells by OX40 cosignaling via sustained PI3k and PKB activation. PMID: 15894279
59. During influenza A virus infection, formation of the same CD8+ memory T cell pool as well as its capacity for secondary expansion depend on the complementary contributions of OX40, CD27, and 4-1BB. PMID: 16034107
60. data demonstrate that OX40 and Bcl-x(L) can control survival of primed CD8 T cells and provide new insights into both regulation of CD8 immunity and control of tumors PMID: 16148096
61. OX40 provides a critical synergistic and temporal signal with other noncytokine receptors to modulate nuclear factor of activated T cells c1 and to promote optimal Th2 generation. PMID: 16501042
62. CD4+ T cell differentiation to effector function is an important effect of OX40 engagement under conditions of ubiquitous antigen presentation. PMID: 16541471
63. OX40 ligand-expressing T cells have an autonomous machinery that provides OX40 signals through a T cell-T cell circuit, creating an additional mechanism for sustaining CD4 T cell longevity. PMID: 16670306
64. The CD134 costimulatory pathway may be important for the adjuvant effect on T cell immunity induced by interleukin (IL)-18. PMID: 16785519
65. We conclude that blocking the OX-40/OX40L interaction reduced atherogenesis by inhibition of IL-4 mediated Th2 induced isotype switching and subsequent increased levels of anti-oxLDL IgM. PMID: 17068285
66. OX40 is a negative regulator of Foxp3 and can concomitantly promote effector T cell generation while antagonizing the differentiation of adaptive Foxp3-positive regulatory T cells. PMID: 17641007
67. OX40 is a critical molecule in regulating survival and functions of depletion-resistant T cells. PMID: 17911646
68. OX40-mediated inactivation of T reg cell function unleashes nearby dendritic cells, allowing them to induce an adaptive immune response. PMID: 18362171
69. OX40 signals regulate T cell number and viability through the NF-kappaB1 pathway that controls expression and activity of intracellular targets for proliferation and survival PMID: 18490723
70. Therapies targeting OX40 dramatically changed the tumor environment by enhancing the infiltration and function of CD8 T cells combined with diminished suppressive influences within the tumor. PMID: 18593921
71. one of the mechanisms by which OX40/OX40L costimulation inhibits the induction of Foxp3(+) Tregs is by inducing memory T cells in vivo. PMID: 18713990
72. OX40 signals are essential for the generation of functional memory CD8-positive T cells. PMID: 18941188
73. T regulatory (Treg) cells directly inhibited the FcvarepsilonRI-dependent mast cells (MC) degranulation through cell-cell contact involving OX40-OX40L interactions between Treg cells and MCs, respectively PMID: 18993084
74. Preventing OX40-OX40 ligand interactions might be useful to enhance the effectiveness of intranasal ovalbumin allergen immunotherapy and ensure the successful induction of tolerance through generating adaptive regulatory T cells. PMID: 19050285
75. Anti-OX40-enhancement of tumor immunity and effector T cell numbers is decreased in middle-aged mice and is partially reversed by coadministration of proinflammatory cytokine IL-12. PMID: 19155495
76. Invariant natural killer T cells expressed the OX40 molecule and promoted type I interferon (IFN) production by plasmacytoid dendritic cells (pDCs) through OX40-OX40 ligand interaction PMID: 19217323
77. Ox40-cre was induced in a small fraction of thymocytes that were OX40(+), some of which were CD25(high) Treg cell precursors PMID: 19342632
78. Cyclophosphamide and OX40 engagement represents a novel and rational chemoimmunotherapy in experimental melanoma. PMID: 19414558
79. Reversal of Treg suppression required T cell-derived interleukin-6 (IL-6) and the OX40/OX40L axis. PMID: 19643985
80. Results suggests that OX40-mediated therapy may provide a novel means of boosting anti-tumor immunity by restoring the responsiveness of previously anergic tumor-specific CD8 T cells. PMID: 19672905

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KEGG: mmu:22163

STRING: 10090.ENSMUSP00000030952

UniGene: Mm.13885