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Based on the hybridoma technology, the BCL2 monoclonal antibody was generated by immunizing mice with a recombinant human BCL2 protein (2-211aa) and fusing their spleen B cells with myeloma cells to create hybridomas. The BCL2 antibody-producing hybridomas were selected for the subsequent culture. Collecting the BCL2 monoclonal antibodies from the mouse ascites. The resulting BCL2 monoclonal antibody specifically binds to human and mouse BCL2 protein and has been shown to be highly specific in ELISA, WB, and FC applications. It is purified to a high degree of purity (>95%) using protein G affinity chromatography.
BCL2 protein plays a crucial role in regulating the mitochondrial pathway of apoptosis. It is an anti-apoptotic protein that prevents apoptosis by binding and sequestering pro-apoptotic proteins, such as BAX and BAK, and preventing them from inducing mitochondrial outer membrane permeabilization (MOMP) and the release of cytochrome c, which initiates the caspase cascade and ultimately leads to cell death. BCL2 is also involved in the regulation of other cellular processes, such as autophagy and oxidative stress.
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