CDC42 Antibody

Datasheet

Code CSB-PA005008GA01HU
Product Type Purified Rabbit Anti human PolyClonal Antibody
Size US$685
Uniprot No. P60953
Abbreviation CDC42
Immunogen Human CDC42
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,WB,IHC
Storage Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method Antigen Affinity Purified
Isotype IgG
Alias cell division cycle 42 (GTP binding protein, 25kDa);CDC42;CDC42Hs;G25K ;
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Target Names CDC42
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Details This protein is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants.
HGNC 1737
RGD 621406
MGI 2441841
Still Have Questions? Leave a Message or Start an on-line Chat
Function Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration. Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups.
Involvement in disease Takenouchi-Kosaki syndrome (TKS)
Subcellular Location Cell membrane, Lipid-anchor, Cytoplasmic side, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cytoplasm, cytoskeleton, spindle, Midbody
Protein Families Small GTPase superfamily, Rho family, CDC42 subfamily
Database Links

HGNC: 1736

OMIM: 116952

KEGG: hsa:998

STRING: 9606.ENSP00000314458

UniGene: Hs.467637

Pathway Chemokine signaling pathway
MAPK signaling pathway
VEGF signaling pathway
Focal adhesion
Regulation of actin cytoskeleton
Adherens junction
Ras signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
T cell receptor signaling pathway
AGE-RAGE signaling pathway in diabetic complications
Rap1 signaling pathway
Endocytosis
Neurotrophin signaling pathway

Related Products

CDC42 Antibodies

CDC42 Antibodies for Homo sapiens (Human)

CDC42 Antibodies for Drosophila melanogaster (Fruit fly)

CDC42 Antibodies for Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)

CDC42 Antibodies for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

CDC42 Antibodies for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

CDC42 Proteins

CDC42 Proteins for Mus musculus (Mouse)

CDC42 Proteins for Homo sapiens (Human)

CDC42 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

CDC42 Proteins for Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

CDC42 Proteins for Candida albicans (strain WO-1) (Yeast)

CDC42 Proteins for Colletotrichum gloeosporioides (Anthracnose fungus) (Glomerella cingulata)

CDC42 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

CDC42 Proteins for Drosophila melanogaster (Fruit fly)

CDC42 Proteins for Anopheles gambiae (African malaria mosquito)

CDC42 Proteins for Aedes aegypti (Yellowfever mosquito) (Culex aegypti)

CDC42 Proteins for Drosophila pseudoobscura pseudoobscura (Fruit fly)

CDC42 Proteins for Bos taurus (Bovine)

CDC42 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

CDC42 Proteins for Rattus norvegicus (Rat)

CDC42 Proteins for Gallus gallus (Chicken)

CDC42 Proteins for Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)

CDC42 cDNA

CDC42 cDNA for Rattus norvegicus (Rat)

CDC42 cDNA for Gallus gallus (Chicken)

Most popular with customers

Newsletters

Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

Copyright © 2007-2018 www.cusabio.com CUSABIO TECHNOLOGY LLC All Rights Reserved.

Wait!

Join the 25,000 subscribers to get research hotpots, technical tips, latest information on events, sales and offers.

Sign up now!

We don't deal in spam.

Wait!

Join the 25,000 subscribers to get research hotpots, technical tips, latest information on events, sales and offers.

Sign up now!

We don't deal in spam.