Your Good Partner in Biology Research
Tel : 301-363-4651
Your Good Partner in Biology Research
| Code | CSB-PA942675 |
| Size | US$297 |
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| Full Product Name | Rabbit anti-Homo sapiens (Human) IGF1R Polyclonal antibody | ||||||
| Uniprot No. | P08069 | ||||||
| Target Names | IGF1R | ||||||
| Alternative Names | CD221; EC 2.7.10.1; IGF1R; Insulin-like growth factor I receptor precursor; kinase IGF1R | ||||||
| Raised in | Rabbit | ||||||
| Species Reactivity | Human,Mouse | ||||||
| Immunogen | Synthesized non-phosphopeptide derived from Human IGF1R around the phosphorylation site of tyrosine 1346 (Q-P-Y(p)-A-H). | ||||||
| Immunogen Species | Homo sapiens (Human) | ||||||
| Clonality | Polyclonal | ||||||
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | ||||||
| Concentration | It differs from different batches. Please contact us to confirm it. | ||||||
| Form | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | ||||||
| Tested Applications | ELISA,WB,IHC | ||||||
| Recommended Dilution |
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| Protocols | ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol |
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| Troubleshooting and FAQs | Antibody FAQs | ||||||
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | ||||||
| Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. | ||||||
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Function | Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways |
| Involvement in disease | Insulin-like growth factor 1 resistance (IGF1RES) |
| Subcellular Location | Cell membrane, Single-pass type I membrane protein |
| Protein Families | Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily |
| Tissue Specificity | Found as a hybrid receptor with INSR in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Expressed in a variety of tissues. Overexpressed in tumors, including melanomas, cancers of the |
| Database Links |
HGNC: 5465 OMIM: 147370 KEGG: hsa:3480 STRING: 9606.ENSP00000268035 UniGene: Hs.643120 |
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Tel: 301-363-4651
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