IGF1R (Ab-1346) Antibody

Datasheet
Code CSB-PA942675
Size US$297
Image
  • Immunohistochemistry analysis of paraffin-embedded human brain tissue using IGF1R (Ab-1346) antibody.
  • Western blot analysis of extracts from A549 cells, using IGF1R (Ab-1346) antibody.
  • Western blot analysis of extracts from 293 cells (Lane 2), using IGF1R (Ab-1346) antiobdy. The lane on the left is treated with synthesized peptide.

Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) IGF1R Polyclonal antibody
Uniprot No. P08069
Target Names IGF1R
Alternative Names CD221; EC 2.7.10.1; IGF1R; Insulin-like growth factor I receptor precursor; kinase IGF1R
Raised in Rabbit
Species Reactivity Human,Mouse
Immunogen Synthesized non-phosphopeptide derived from Human IGF1R around the phosphorylation site of tyrosine 1346 (Q-P-Y(p)-A-H).
Immunogen Species Homo sapiens (Human)
Clonality Polyclonal
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Form Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
IHC 1:50-1:100
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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Target Data

Function Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways
Involvement in disease Insulin-like growth factor 1 resistance (IGF1RES)
Subcellular Location Cell membrane, Single-pass type I membrane protein
Protein Families Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily
Tissue Specificity Found as a hybrid receptor with INSR in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Expressed in a variety of tissues. Overexpressed in tumors, including melanomas, cancers of the
Database Links

HGNC: 5465

OMIM: 147370

KEGG: hsa:3480

STRING: 9606.ENSP00000268035

UniGene: Hs.643120

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