Product Details

Purity

Greater than 90% as determined by SDS-PAGE.

Target Names

LATH

Uniprot No.

P82615

Research Area

others

Alternative Names

LATHLatherin; Dander allergen Equ c 4/Equ c 5; allergen Equ c 4

Species

Equus caballus (Horse)

Source

Yeast

Expression Region

21-228aa

Target Protein Sequence

QQIPPEVSSQITDALTQGLLDGNFLSLLNAINLEGLLNTILDQVTGLLNILVGPLLGPSDAEIKLQDTRLLQLSLEFSPDSKGIDIWIPLELSVYLKLLILEPLTLYVRTDIRVQLRLESDEDGKYRLAFGHCSLLPRAIELQSGNPLSLPVNAVLGTIENALGNFITEDLGAGLCPTLNSLVSNLDLQLVNNLINLILDRANVDLSV
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Mol. Weight

24.6kDa

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal 6xHis-tagged

Form

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet & COA

Please contact us to get it.

Description

LATH, also known as BPIFA4, is a protein belonging to the palate lung and nasal epithelium clone (PLUNC) family, commonly found in the oral cavity and saliva of mammals [1]. In the context of plant biology, LATH has been identified as encoding a WUSCHEL-Related Homeobox1 transcription factor, playing a crucial role in controlling organ lateral outgrowth and modulating organ identities in compound leaf and zygomorphic flower development in garden pea (Pisum sativum L.) [2]. The molecular control of tendril development in angiosperms has also implicated LATH in repressing the activity of certain proteins, possibly from the HD‐ZIP III family or other polarity establishment gene family, to regulate the function of the distal domain of pea leaves [3].

References:
[1] M. Al-Abri, H. Holl, S. Kalla, N. Sutter, & S. Brooks, "Whole genome detection of sequence and structural polymorphism in six diverse horses", Plos One, vol. 15, no. 4, p. e0230899, 2020. https://doi.org/10.1371/journal.pone.0230899
[2] L. Zhuang, M. Ambrose, C. Rameau, L. Weng, J. Yang, H. Xiuet al., "Lathyroides, encoding a wuschel-related homeobox1 transcription factor, controls organ lateral growth, and regulates tendril and dorsal petal identities in garden pea (pisum sativum l.)", Molecular Plant, vol. 5, no. 6, p. 1333-1345, 2012. https://doi.org/10.1093/mp/sss067
[3] M. Sousa‐Baena, L. Lohmann, J. Hernandes‐Lopes, & N. Sinha, "The molecular control of tendril development in angiosperms", New Phytologist, vol. 218, no. 3, p. 944-958, 2018. https://doi.org/10.1111/nph.15073

Target Background

Function

Major protein in sweat, has surfactant properties. Has a role in temperature regulation by having a capacity to make hydrophobic surfaces wettable and so can function in promoting spreading and evaporation of sweat.

Gene References into Functions

Latherin may represent a multifunctional surfactant protein, a wetting agent in sweat, in host defense against biofilm formation and to aid digestive PMID: 21787340
The amino acid sequence of latherin, determined from cDNA analysis, is highly conserved across four geographically dispersed equid species and is similar to a family of proteins only found previously in the oral cavity and associated tissues of mammals. PMID: 19478940

Subcellular Location

Secreted.

Protein Families

BPI/LBP/Plunc superfamily, Plunc family

Tissue Specificity

Found in sweat (at protein level).

Database Links

KEGG: ecb:100033921

STRING: 9796.ENSECAP00000007784

UniGene: Eca.12955

Code	CSB-YP306756HO
Abbreviation	Recombinant Horse LATH protein
MSDS	MSDS Datasheet
Size	$436
	Order now
Image	(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Have Questions?	Leave a Message or Start an on-line Chat

Recombinant Horse Latherin (LATH)

Product Details

Related Products

Customer Reviews and Q&A

Target Background

×CloseMessage