Recombinant Human Tyrosine-protein kinase Fyn (FYN)

1. SPHK2 is highly expressed in the kidney interstitium of patients with renal fibrosis and highly correlates with disease progression. SPHK2 phosphorylates Fyn to activate downstream STAT3 and AKT, thereby promoting extracellular matrix synthesis, kidney fibroblast activation, and renal fibrosis. PMID: 30251698
2. Fyn and Lyn as important factors that promote Plasmacytoid dendritic cell responses. PMID: 28368000
3. Data suggest that Fyn tyrosine kinase (Fyn)-dependent phosphorylation at two critical tyrosines is a key feature of vertebrate plexin A1 (PlxnA1) and plexin A2 (PlxnA2) signal transduction. PMID: 29091353
4. Nav1.7 is a substrate for Fyn kinase. PMID: 29790812
5. Fyn binds to mGluR1a at a consensus binding motif located in the intracellular C-terminus (CT) of mGluR1a in vitro. Active Fyn phosphorylates mGluR1a at a conserved tyrosine residue in the CT region. In cerebellar neurons and transfected HEK293T cells, Fyn-mediated tyrosine phosphorylation of mGluR1a is constitutively active and facilitates surface expression of mGluR1a and potentiates mGluR1a postreceptor signaling. PMID: 28948209
6. High FYN expression is associated with pancreatic cancer metastasis. PMID: 28560430
7. Study was the first to demonstrate critical positive regulation of thyroid tumorigenesis by FYN, which could be a potential target gene for thyroid carcinoma treatment. PMID: 29140740
8. Fyn-dependent phosphorylation of SHP-1 serine 591 inactivates the phosphatase, enabling activatory immunoreceptor signaling. PMID: 28811476
9. upregulated in fibrotic kidneys PMID: 27616741
10. Study identified the binding site between tau and fyn-SH3 may facilitate the development of compounds that can inhibit tau-fyn interactions, which presents an alternative therapeutic strategy for Alzheimer's disease; and provide evidence that a physiological correlation between phosphorylated tau at S202, S262, and S396/404 and fyn is not present in Alzheimer's disease brain. PMID: 27193083
11. FYN expression is regulated according to AD status and regulatory region haplotype, and genetic variants may be instrumental in the development of neurofibrillary tangles in AD and other tauopathies. PMID: 28033507
12. a substantial fraction of unligated CD36 exists in nanoclusters, which not only promote TSP-1 binding but are also enriched with the downstream effector Fyn. PMID: 27694211
13. Upon SMAD4 deletion, we detected high expression levels of FYN in vessel endothelial cells, suggesting the mechanism of the ovarian tumor cells cross the endothelial barrier and transform to an invasive phenotype PMID: 28393199
14. Study reveal that binding the phosphorylated tail of Fyn perturbs a residue cluster near the linker connecting the SH2 and SH3 domains of Fyn, which is known to be relevant in the regulation of the activity of Fyn. PMID: 27692963
15. The data suggest that miR-106b inhibits Amyloid-beta (1-42)-induced tau phosphorylation at Tyrosine 18 by targeting Fyn. PMID: 27520374
16. FYN was transcriptionally regulated by FOXO1. PMID: 27349276
17. Results found that GluN2B subunit-containing NMDARs were dominant in induced pluripotent stem cell-derived neurons and that tyrosine-protein kinase Fyn potentiated the function of GluN2B subunit-containing NMDARs. PMID: 27040756
18. These results indicate that the microenvironment and growth patterns in an multicellular spheroid are complex and require MAPK and FYN kinase PMID: 27466485
19. this study shows that p59(fyn), which is essential for activation of T cells through the T-cell receptor, is also critical for signal transduction through Toll-like receptors in T cells PMID: 26888964
20. Fyn expression fluctuated with the progress of normal pregnancy and was elevated in patients with recurrent spontaneous abortion PMID: 26892111
21. Neuroendocrine differentiation in prostate cancer cells and visceral metastasis, are least in part, regulated by FYN kinase. PMID: 26624980
22. Fyn facilitates mitotic spindle formation through the increase in microtubule polymerization, resulting in the acceleration of M-phase progression. PMID: 26365631
23. Results show that three CpG loci within FYN were hypermethylated in obese individuals, while obesity was associated with lower methylation of CpG loci within PIWIL4 and TAOK3. PMID: 26646899
24. Data provide structural insight into the dimerization of Fyn SH2 both in solution and in crystalline conditions, providing novel crystal structures of both the dimer and peptide-bound structures of Fyn SH2. PMID: 26384592
25. Mutation of Fyn phosphorylation sites on PIKE-A, depletion of Fyn, or pharmacological inhibition of Fyn blunts the association between PIKE-A and AMPK, resulting in loss of its inhibitory effect on AMPK. PMID: 26001218
26. Results show that Fyn differentially modulates Nav1.5 channel splice variants. It phosphorylates Nav1.5 variants Q-del and Q-pre resulting in there hyperpolarizing and depolarizing shift. Fyn's activity is abolished in the presence of both variants. PMID: 26382759
27. In this study, it is shown that the alternatively spliced FynT isoform is specifically up-regulated in the AD neocortex, with no change in FynB isoform. PMID: 26561212
28. our results provide no evidence that the Fyn -93A>G SNP contributes to the susceptibility to acute liver transplant rejection in a Caucasian population. PMID: 26407913
29. Data suggest both KLF5 (Kruppel like factor 5) and FYN are important in regulation of migration in bladder cancer cells; KLF5 up-regulates cell migration, lamellipodia formation, FYN expression, and phosphorylation of FAK (focal adhesion kinase). PMID: 26786295
30. Our results establish that Fyn can arrest SW-induced apoptosis via the activity of Akt and its effective phosphorylation in 293T cells. PMID: 26125726
31. Fyn inhibition may be an effective therapeutic approach in treating cSCC. PMID: 24976598
32. the main finding is that FYN polymorphisms were respon- sible for the variance in intermediate defense style(undoing)and mature defensestyle(suppression). PMID: 25130779
33. Results indicate that FYN has an important role in tamoxifen resistance, and its subcellular localization in breast tumor cells may be an important novel biomarker of response to endocrine therapy in breast cancer. PMID: 24882577
34. it is not just inactivation of Fyn that promotes multicellular spheroid formation but this must be coupled with the full length beta6 integrin. PMID: 25503120
35. these results demonstrate a Fyn kinase-dependent mechanism through which IFNgamma regulates E-cadherin stability and suggest a novel mechanism of disruption of epithelial cell contact, which could contribute to perturbed epithelial barrier function. PMID: 22715382
36. The SNPs in the selected regions of the Fyn gene are unlikely to confer the susceptibility of sAD in the Chinese Han population PMID: 24852829
37. Fyn expression in mdMSCs contributes to basal cytoskeletal architecture and, when associated with FAs, functions as a proximal mechanical effector for environmental signals that influence MSC lineage allocation. PMID: 23836527
38. These results provided suggestive evidence that the FYN gene contributes toward the variance in human coping styles. PMID: 23851594
39. monomeric IgE, in the absence of antigen, induces VEGF production in MC and in vivo contributes to melanoma tumor growth through a Fyn kinase-dependent mechanism. PMID: 23915951
40. positively regulates IFN-lambda1 genes during viral infection PMID: 23405030
41. PrP(C) down-regulated tau via the Fyn pathway and the effect can be regulated by Abeta oligomers. PMID: 23805846
42. Mutations in FYN implicate SRC signaling, impaired DNA damage response, and escape from immune surveillance mechanisms in the pathogenesis of peripheral T cell lymphomas. PMID: 24413734
43. MicroRNA-125a-3p reduces cell proliferation and migration by targeting Fyn. PMID: 23606749
44. These data demonstrate a mechanism whereby Fyn and Lyn, redundantly mediate anticryptococcal killing by inducing the polarization of perforin-containing granules to the NK cell-cryptococcal synapse. PMID: 23918783
45. no association between FYN polymorphisms and schizophrenia risk or age at schizophrenia onset, was found. PMID: 23250004
46. Expression of HPV type 16 E7 resulted in increase in Src and Yes proteins level, but did not alter the level of Fyn. PMID: 23497302
47. Highlighted is recent evidence that FYN kinase mediates signal transduction downstream of the PrP(C)-ABETA oligomer complex in Alzheimer disease. [review] PMID: 22987042
48. Fyn regulates the activity of the adipogenic transcription factor signal transducer and activator of transcription 5a (STAT5a) through enhancing its interaction with the GTPase phosphoinositide 3-kinase enhancer A (PIKE-A). PMID: 23438599
49. Nck may facilitate dynamic signaling events at the slit diaphragm by promoting Fyn-dependent phosphorylation of nephrin. PMID: 23188823
50. The results presented from this in silico study will open up new prospect for genetic analysis of FYN gene and their correlation with clinical data will be very useful in understanding the genetics of Alzheimer's disease. PMID: 22843238

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HGNC: 4037

OMIM: 137025

KEGG: hsa:2534

STRING: 9606.ENSP00000346671

UniGene: Hs.390567