FYN (proto-oncogene tyrosine-protein kinase Fyn), also designated SLK or SYN, is a Src-family non-receptor tyrosine kinase regulating diverse cellular processes through phosphorylation-mediated signaling. It interacts with scaffolding adaptors like PAG/Cbp to modulate T-cell receptor activation and integrin-mediated adhesion via downstream effectors including FAK and paxillin. FYN participates in critical pathways such as B-cell receptor signaling, Wnt/β-catenin modulation, and NMDA receptor trafficking in neurons. Aberrant FYN activity is implicated in Alzheimer's disease through Tau protein hyperphosphorylation, multiple sclerosis via immune cell dysregulation, and malignancies like glioblastoma and hormone-resistant prostate cancers. While pan-Src kinase inhibitors (e.g., dasatinib) show partial FYN inhibition, selective FYN-targeted therapies remain investigational. Recent preclinical efforts focus on disrupting FYN's SH3 domain interactions and its synergistic role with EGFR/PDGFR in tumor invasiveness.
FYN Recombinant Monoclonal Antibody (CSB-RA699767A0HU)
Validated Data
IHC image of CSB-RA699767A0HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
IHC image of CSB-RA699767A0HU diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
The following FYN reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
FYN Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA112548 | Phospho-FYN (Tyr530) Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA914183 | FYN (Ab-530) Antibody | Human,Mouse | ELISA,WB |
CSB-PA002595 | FYN Antibody | Human,Mouse,Rat | WB, ELISA |
CSB-PA008519 | Phospho-FYN (Y530) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA008520 | FYN Antibody | Human,Mouse,Rat | WB, ELISA |
CSB-PA143385 | FYN Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA225018 | FYN Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA009101LA01HU | FYN Antibody | Human | ELISA, IHC, IF |
CSB-RA699767A0HU | FYN Recombinant Monoclonal Antibody | Human | ELISA, IHC |
FYN Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP009101MO CSB-EP009101MO CSB-BP009101MO CSB-MP009101MO CSB-EP009101MO-B |
Recombinant Mouse Tyrosine-protein kinase Fyn (Fyn) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FYN Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP009101HU CSB-EP009101HU CSB-BP009101HU CSB-MP009101HU CSB-EP009101HU-B |
Recombinant Human Tyrosine-protein kinase Fyn (FYN) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FYN Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP009101BO CSB-EP009101BO CSB-BP009101BO CSB-MP009101BO CSB-EP009101BO-B |
Recombinant Bovine Tyrosine-protein kinase Fyn (FYN), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FYN Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-YP009101PI CSB-EP009101PI CSB-BP009101PI CSB-MP009101PI CSB-EP009101PI-B |
Recombinant Pig Tyrosine-protein kinase Fyn (FYN), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FYN Proteins for Xenopus laevis (African clawed frog)
Code | Product Name | Source |
---|---|---|
CSB-YP009101XBE CSB-EP009101XBE CSB-BP009101XBE CSB-MP009101XBE CSB-EP009101XBE-B |
Recombinant Xenopus laevis Tyrosine-protein kinase Fyn (fyn), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FYN Proteins for Xiphophorus helleri (Green swordtail)
Code | Product Name | Source |
---|---|---|
CSB-YP009101XBJ CSB-EP009101XBJ CSB-BP009101XBJ CSB-MP009101XBJ CSB-EP009101XBJ-B |
Recombinant Xiphophorus helleri Tyrosine-protein kinase Fyn (fyn), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FYN Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP723478RA CSB-EP723478RA CSB-BP723478RA CSB-MP723478RA CSB-EP723478RA-B |
Recombinant Rat Tyrosine-protein kinase Fyn (Fyn) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |