Tyrosine-protein kinase Fyn is a protein in humans that is encoded by FYN gene. Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage.

FYN Antibodies

FYN Antibodies for Homo sapiens (Human)

FYN Proteins

FYN Proteins for Mus musculus (Mouse)

FYN Proteins for Homo sapiens (Human)

FYN Proteins for Bos taurus (Bovine)

FYN Proteins for Sus scrofa (Pig)

FYN Proteins for Xenopus laevis (African clawed frog)

FYN Proteins for Xiphophorus helleri (Green swordtail)

FYN Proteins for Rattus norvegicus (Rat)


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