Recombinant Mouse Calpastatin,isoform 5 (Cast)

1. The knockdown of CAST in mutant huntingtin-expressing cells and the knockout of the Cast gene in a knock-in mouse model of HD resulted in a worsening of the molecular HD-related hallmarks including elevated formation of huntingtin fragments and increased amount of respective aggregates PMID: 29355642
2. Defective scar formation after myocardial infarction in calpastatin transgenic mice was associated with blunted CD4(+) T-cell and M2-macrophage recruitment. PMID: 26453333
3. EC-specific transgenic CAST downregulated JAK/STAT signals, upregulated SOCS3, and depleted VEGF-C, counteracting unstable pathological neovessels and disease progression in tumors and oxygen-induced retinopathy lesions in mice. PMID: 25648699
4. We observed that ischemia induction results in increased expression of CaN, Calp and Calpn. PMID: 24333421
5. Over-expression of calpastatin enhances doxorubicin-induced cardiac injuries through calpain inhibition. PMID: 23455548
6. Data show that genetic deficiency of calpastatin (CS) augmented Abeta amyloidosis, tau phosphorylation, microgliosis, and somatodendritic dystrophy, and increased mortality in amyloid precursor protein (APP) transgenic mice. PMID: 22173972
7. PIN1 apparently restrains the ability of calpastatin to inhibit calpain, maintaining calpain activity in endothelial cells. PMID: 21982763
8. Calpastatin is likely to be more closely associated with affective rather than cognitive aspects of brain function. PMID: 18803809
9. Blocking endogenous calpain activity partially impairs insulin release in vivo and in vitro by targeting distal components of the insulin exocytotic machinery. PMID: 21099278
10. Calpain inhibition by overexpressing CAST in transgenic mice attenuates skin allograft rejection by a delay in T-cell mobilization. PMID: 21268016
11. Ectopic expression in pachytene spermatocytes suppressed germ cell apoptosis. PMID: 15223839
12. apoptotic responses were augmented by calpastatin deficiency. Consistently calpastatin overexpression suppressed them PMID: 15691848
13. calpain and caspase activation have roles in neurodegeneration, as demonstrated in calpastatin-transgenic mice PMID: 15699033
14. Western blot analysis of the mouse brain showed reduced levels of calpastatin and rabaptin-5 and higher amount of neuronatin in PKU compared to the wild type. PMID: 15863237
15. Findings suggest that calpastatin transgenic mice results in impairment of a step in the GLUT4 translocation process downstream of the insulin- and contraction-signaling pathways. PMID: 16705056
16. Calpastatin is an important factor in the regulation of calpain-induced protein degradation in the brains of the affected mice, implying a role for calpastatin in attenuating AD pathology PMID: 17513017
17. Calpastatin gene transfer prevented cardiovascular remodeling in AngII-dependent hypertension. PMID: 18258859

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KEGG: mmu:12380

STRING: 10090.ENSMUSP00000065275

UniGene: Mm.29163