Recombinant Mouse CD44 antigen(Cd44)

Code CSB-CF004938MO
Size Pls inquire
Source in vitro E.coli expression system
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Product Details

Target Names Cd44
Uniprot No. P15379
Alternative Names Cd44; Ly-24CD44 antigen; Extracellular matrix receptor III; ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Hermes antigen; Hyaluronate receptor; Lymphocyte antigen 24; Ly-24; Phagocytic glycoprotein 1; PGP-1; Phagocytic glycoprotein I; PGP-I; CD antigen CD44
Species Mus musculus (Mouse)
Expression Region 23-778
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Target Data

Function Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis (By similarity). Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function
Gene References into Functions
  1. this study shows that absence of specific alternatively spliced exon of CD44 in macrophages prevents colitis PMID: 29186109
  2. this study demonstrates a new role for CD44 and hyaluronan in promoting alveolar macrophage survival PMID: 29067996
  3. CD44-positive proliferating glomerular cells, most likely parietal epithelial cells, are essential in the pathogenesis of scarring glomerular disease. PMID: 29276101
  4. We show here that cleavage-stimuli-induced specific ICD-modifications cause structural substrate changes that enhance ectodomain sensitivity of neuregulin-1 (NRG1; epidermal-growth-factor) or CD44 (receptor-tyrosine-kinase (RTK) co-receptor) to chymotrypsin/trypsin or soluble ADAM. PMID: 27876763
  5. TGF-beta1-mediated hyaluronan/CD44/STAT3 signaling pathway plays a crucial role in the development of atrial fibrosis and atrial fibrillation. PMID: 28871329
  6. The role of CD44 was evaluated in CD44(-/-) challenged with a methionine- and choline-deficient diet (MCDD). Liver inflammation, liver injury and fibrosis strongly decreased in CD44(-/-) mice compared to wild-type mice on MCDD. PMID: 28323124
  7. Data (including data from studies using transgenic mice) suggest that a single oral dose of vitamin A (1) amplifies tolerogenic activity of dendritic cells migrating to lymphoid tissue and (2) up-regulates expression of Foxp3 and Cd44 in co-cultures of dendritic cells and CD4+ lymphocytes. (Foxp3 = forkhead box P3; Cd44 = homing receptor) PMID: 28917953
  8. The pseudo-hypoxic phenotype of stem-like glioma cells is achieved by stabilization of HIF-2a through interaction with CD44, independently of oxygen. PMID: 28813675
  9. the survival outcomes of genetically induced glioma-bearing mice and of high-grade human glioma patients are biphasically correlated with CD44 level, with the poorest outcomes occurring at intermediate levels. PMID: 28052252
  10. pERK1/2 is a regulator of CD44 expression, and increased CD44 expression leads to a pro-sclerotic and migratory parietal epithelial cell phenotype in focal segmental glomerulosclerosis. PMID: 27998643
  11. MET signaling regulates intestinal homeostasis and regeneration, as well as adenoma formation. These activities of MET are promoted by the stem cell CD44 isoform CD44v4-10. PMID: 28716720
  12. study demonstrates that CD44 plays a critical role in the regulation of experimental autoimmune encephalomyelitis through alterations in the gut microbiome profile and short-chain fatty acid production PMID: 28543188
  13. CD44 variant isoform 9 emerges in response to injury and contributes to the regeneration of the gastric epithelium. PMID: 28497484
  14. OA/GPNMB acts through ERK and AKT signaling pathways in mesenchymal stem cells via CD44 PMID: 26442636
  15. These findings support the usefulness of the conditional Cd44 allele in unraveling essential physiological and pathological functions of CD44 isoforms. PMID: 27831556
  16. CD44 role in the atrophic epidermis PMID: 28099467
  17. CD44(high) type II cells likely represent a type II cell subpopulation important for constitutive regulation of alveolar homeostasis. PMID: 28473330
  18. CD44V6 is part of a positive-feedback loop with TGFbeta1/TGFbetaRI signaling that acts to increase NOX4/ROS production, which is required for myofibroblast differentiation, myofibroblast differentiation, myofibroblast extracellular matrix production, myofibroblast invasion, and myofibroblast contractility. PMID: 28389561
  19. HAS2-produced hyaluronan is required for CD44V6 and TGFbetaRI co-localization and subsequent CD44V6/ERK1/EGR1 signaling. These results demonstrate a novel positive-feedback loop that links the myofibroblast phenotype to TGFbeta1-stimulated CD44V6/ERK/EGR1 signaling. PMID: 28389562
  20. CD44 promotes accumulation of M2 macrophages, extracellular matrix deposition, and wall thickening during arteriovenous fistula maturation. PMID: 28450292
  21. CD44-expressing Neural Stem Cells are self-renewing and multipotent and they synthesize Hyaluronan that accumulates with aging. CD44-null Neural Stem Cells demonstrate increased proliferation in vitro and in vivo. PMID: 28154169
  22. CD44 knockout mice are more susceptible to stress-induced anxiety-like behavior than control mice. PMID: 27619521
  23. CD44 contributes to effective antibacterial defense during S. zooepidemicus infection, thereby limiting the accompanying injury and death. PMID: 28062002
  24. These studies demonstrate that both endometrial cell and peritoneal mesothelial cell CD44 play a role in the development of early endometriotic lesion. PMID: 26169039
  25. Targeting CD44 expressing colon cancer cells with anti-CD44 monoclonal antibody improves cellular uptake and antitumor efficacy of liposomal doxorubicin. PMID: 26518722
  26. depletion of CD44s inhibits breast cancer cell metastasis to the lung in animals. These findings suggest a crucial mechanism underlying the role of the CD44s splice isoform in breast cancer metastasis. PMID: 26869223
  27. MGK as hydrophobic moieties and oHA as the target of CD44 receptor. PMID: 24892632
  28. CD44, NOD2, and Fas have distinct functions in regulating changes in trabecular and cortical bone indices during unloading. PMID: 26546009
  29. The absence of CD44 in neonatal bone marrow has no impact on the size of the long-term reconstituting hematopoietic stem cell pool, but results in an enhanced long-term engraftment potential of hematopoietic stem cells. PMID: 26546504
  30. CD44 deficiency can reduce osteoclast activity and counteract cortical bone loss in the hindlimb of unloaded mice. PMID: 26530337
  31. Genetic deficiency of CD44 augments activation, apoptosis and pro-thrombotic potential of platelets. PMID: 26355696
  32. The high targeting ability of HA-MFNPs was observed at MKN-45 cells (gastric cancer cell line) which high-expressing CD44 in contrast with MKN-28 cells which low-expressing CD44. PMID: 27398445
  33. the aggravation of pulmonary inflammation upon combined exposure to allergen and an environmental pollutant is CD44-dependent. PMID: 26999446
  34. CD44 promotes chemoresistance in T-ALL by increased drug efflux. PMID: 26708679
  35. HA-binding to CD44-expressing beta cells is implicated in beta-cell demise PMID: 26624007
  36. Peptide inhibitors of CD44v6 isoforms block tumor growth and metastasis in several independent models of pancreatic cancer. PMID: 26597578
  37. Suggest CD44 is involved in the development of mucous metaplasia in mice infected with Helicobacter pylori. PMID: 26639196
  38. CD44 enhances T cell receptor signaling strength by delivering lymphocyte-specific protein kinase, which is required for induction of IL-17 producing T helper cells PMID: 26172046
  39. Endogenous hyaluronic acid increases Lgr5(+) stem cell proliferation, crypt fission, and intestinal lengthening and that these effects are dependent on signaling through CD44 and TLR4. PMID: 26505972
  40. consistent with CD44's pivotal role in modulating several diverse behaviors important for adhesion, proliferation, apoptosis, migration and invasion during development, growth, repair, maintenance and regression of a wide variety of mesenchymal tissues PMID: 26248063
  41. The current study reports a unique approach to study H. pylori interaction with the human gastric epithelium. Here, we show that CD44 plays a functional role in H. pylori-induced epithelial cell proliferation. PMID: 25658601
  42. CD44 and pro-NRG1 are posttranslationally modified at their intracellular domains. PMID: 26217011
  43. Data indicate that a short course of anti-CD44 treatment improved Treg cell therapy efficacy in type 1 diabetes (T1D) model. PMID: 25447401
  44. Thymic innate CD8(+)CD44(hi) SP T-cells have critical roles in influenza A(H1N1)pdm09 infection-induced thymic atrophy through secreting IFN-gamma. PMID: 25275588
  45. CD44 deficiency could result in decreased proinflammatory cytokine production in lung induced by porcine circovirus type 2 (PCV2) in mice, suggesting a previously unrecognized role for CD44 in the development of pneumonia response to PCV2 infection. PMID: 25294252
  46. PRG4 is a novel putative ligand for CD44 and may control synoviocyte overgrowth in inflammatory arthropathies via a CD44-mediated mechanism. PMID: 25708025
  47. These data support an important role for CD44 in locomotor and sensorimotor functions, and in spatial memory retention. PMID: 25219362
  48. This study displays for the first time a different role of CD44-specific isoforms in the progression of chronic kidney disease. PMID: 24717295
  49. We hypothesize that polyvalent electrostatic interactions are responsible for the assembly of CD44 clusters and the multimeric PIP2-CD44-Ezrin complexes. PMID: 25572402
  50. of the transcripts of tissue inhibitors of matrix metalloproteinases (TIMPs) showed that expression of both TIMP1 and TIMP2 correlates negatively with the invasive potential of cells. PMID: 25180193

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Subcellular Location Cell membrane, Single-pass type I membrane protein
Database Links

KEGG: mmu:12505

STRING: 10090.ENSMUSP00000005218

UniGene: Mm.423621


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