Recombinant Mouse CD44 antigen(Cd44)

Code CSB-CF004938MO
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. P15379
Storage Buffer Tris-based buffer,50% glycerol
Species Mus musculus (Mouse)
Source in vitro E.coli expression system
Gene Names Cd44
Protein Names Recommended name: CD44 antigen Alternative name(s): Extracellular matrix receptor III Short name= ECMR-III GP90 lymphocyte homing/adhesion receptor HUTCH-I Hermes antigen Hyaluronate receptor Lymphocyte antigen 24 Short name= Ly-24 P
Expression Region 23-778
Tag Info N-terminal 10xHis-tagged
Protein Description Full Length of Mature Protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis (By similarity). Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function
Subcellular Location Cell membrane, Single-pass type I membrane protein
Database Links

KEGG: mmu:12505

STRING: 10090.ENSMUSP00000005218

UniGene: Mm.423621

Pathway Hematopoietic cell lineage

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