Code | CSB-CF008424MO |
Size | $878 |
Order now | |
Image |
|
Have Questions? | Leave a Message or Start an on-line Chat |
This recombinant MouseFap protein is an in vitro E.coli (cell-free) expressed Extracellular Domain protein. Its purity is 90%+ determined by SDS-PAGE. Cell-free protein expression is the in vitro synthesis of a protein using translation-compatible extracts of whole cells. In principle, whole-cell extracts contain all the macromolecules and components needed for transcription, translation, and even post-translational modification. These components include RNA polymerase, regulatory protein factors, transcription factors, ribosomes, and tRNA. When supplemented with cofactors, nucleotides, and the specific gene template, these extracts can synthesize proteins of interest in a few hours.
Fap is a membrane-inserted prolyl-specific serine protease with both endopeptidase and dipeptidase activities. It is specifically expressed by active fibroblasts. Reactive stromal fibroblasts overexpress Fap during the growth of epithelial-derived tumors. Fap is upregulated in many types of human cancers, including breast, brain, and ovarian cancers. Mounting findings have revealed that Fap expression affects tumor growth by influencing tumor cell proliferation and invasion, angiogenesis, epithelial-to-mesenchymal transition (EMT), immunosuppression, and drug resistance.There are currently no reviews for this product.