ACTB Research Reagents

Actin, cytoplasmic 1 is a protein in humans that is encoded by ACTB gene. Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

The following ACTB reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

ACTB Antibodies

ACTB Antibodies for Homo sapiens (Human)

ACTB Antibodies for Mus musculus (Mouse)

ACTB Antibodies for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)

ACTB Proteins

ACTB Proteins for Oryctolagus cuniculus (Rabbit)

ACTB Proteins for Bos taurus (Bovine)

ACTB Proteins for Gallus gallus (Chicken)

ACTB Proteins for Ovis aries (Sheep)

ACTB Proteins for Mus musculus (Mouse)

ACTB Proteins for Homo sapiens (Human)

ACTB Proteins for Equus caballus (Horse)

ACTB Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

ACTB Proteins for Oryzias latipes (Japanese rice fish) (Japanese killifish)

ACTB Proteins for Oreochromis mossambicus (Mozambique tilapia) (Tilapia mossambica)

ACTB Proteins for Cyprinus carpio (Common carp)

ACTB Proteins for Ctenopharyngodon idella (Grass carp) (Leuciscus idella)

ACTB Proteins for Camelus dromedarius (Dromedary) (Arabian camel)

ACTB Proteins for Chlorocebus pygerythrus (Vervet monkey) (Cercopithecus pygerythrus)

ACTB Proteins for Phytophthora infestans (Potato late blight fungus) (Botrytis infestans)

ACTB Proteins for Xenopus borealis (Kenyan clawed frog)

ACTB Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)

ACTB Proteins for Trichosurus vulpecula (Brush-tailed possum)

ACTB Proteins for Rattus norvegicus (Rat)

ACTB Proteins for Salmo salar (Atlantic salmon)

ACTB Proteins for Xenopus laevis (African clawed frog)

ACTB Proteins for Bos mutus grunniens (Wild yak) (Bos grunniens)

ACTB Proteins for Spermophilus citellus (European suslik) (Citellus citellus)

ACTB Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

ACTB Proteins for Pan troglodytes (Chimpanzee)

ACTB Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

ACTB Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

ACTB Proteins for Sus scrofa (Pig)

ACTB Proteins for Cavia porcellus (Guinea pig)

ACTB Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)

ACTB Proteins for Mesocricetus auratus (Golden hamster)

ACTB Proteins for Sigmodon hispidus (Hispid cotton rat)

ACTB ELISA Kit

ACTB ELISA Kit for Homo sapiens (Human)

ACTB Background

The ACTB gene provides instructions for encoding the cytoskeletal protein beta-actin, which is one of six different actin proteins and also an abundant cytoskeletal housekeeping protein. Beta-actin proteins are found in cells throughout the body. The molecular weight of ACTB is approximately 42 kDa. It plays an important role in determining cell shape and controlling cell movement (motility). Studies suggest that beta-actin may also be involved in relaying chemical signals within cells. Beta-actin has been shown to activate eNOS, thereby increasing NO production [1]. Recurrent mutations in this gene have been linked to cases of diffuse large B-cell lymphoma [2]. Due to its high conservation, beta-actin is usually used as a loading control for the integrity of cells and protein degradation in PCR and Western blotting [3]. The ACTB gene mutations cause Baraitser-Winter syndrome (BRWS), which is characterized by intellectual disability, cortical malformations, coloboma, sensorineural deafness, and a distinctive facial appearance in human patients [4]. Many biological studies suggest that a significant reduction of ACTB protein alters cell shape, migration, proliferation, and gene expression, thus leading to the detriment of brain, heart, and kidney development [4]. Although recurrent SERPINE1-FOSB gene fusions have been reported as the hallmark genetic abnormality in pseudomyogenic hemangioendothelioma (PHE), few cases with typical histology have this genetic alteration. Agaram NP et al. identified a novel ACTB-FOSB gene fusion in genetic alterations of pseudomyogenic hemangioendothelioma (PHE), which is rare, hardly metastasizing vascular neoplasm with a predilection to affect young adults [5].

[1] Kondrikov D, Fonseca FV, et al. Beta-actin association with endothelial nitric-oxide synthase modulates nitric oxide and superoxide generation from the enzyme [J]. The Journal of Biological Chemistry. Feb 2010, 285 (7): 4319-7.
[2] Lohr JG, Stojanov P, et al. Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing [J]. Proceedings of the National Academy of Sciences of the United States of America. Mar 2012, 109 (10): 3879-4.
[3] Ruan W, Lai M. Actin, a reliable marker of internal control [J]? Clin Chim Acta. 2007 Oct;385(1-2):1-5.
[4] Cuvertino S, Stuart HM, et.al. ACTB Loss-of-Function Mutations Result in a Pleiotropic Developmental Disorder [J]. Am J Hum Genet. 2017 Dec 7;101(6):1021-1033.
[5] Agaram NP, Zhang L, et al. Expanding the Spectrum of Genetic Alterations in Pseudomyogenic Hemangioendothelioma With Recurrent Novel ACTB-FOSB Gene Fusions [J]. Am J Surg Pathol. 2018 Dec;42(12):1653-1661.

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