ADRB3

Adrenoceptor Beta 3 (ADRB3) is a G-protein coupled receptor (GPCR) encoded by the ADRB3 gene, also known as the beta-3 adrenergic receptor. It binds catecholamines (norepinephrine, epinephrine) and couples to Gs proteins, activating adenylate cyclase to increase cyclic AMP (cAMP) levels. This pathway drives lipolysis in white adipose tissue and thermogenesis in brown adipose tissue, key for energy metabolism regulation.
ADRB3 variants like the Trp64Arg polymorphism are associated with obesity, insulin resistance, and type 2 diabetes. Selective agonists are under development: mirabegron (approved for overactive bladder) shows off-target ADRB3 activity and is being studied for metabolic disorders. Ongoing trials explore agonists to boost energy expenditure and improve glucose homeostasis in diabetes and obesity.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ADRB3 Antibody (CSB-PA235900)

Validated Data

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA235900(ADRB3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA235900(ADRB3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)

Gel: 8%SDS-PAGE,Lysate: 40 μg,,Primary antibody: CSB-PA235900(ADRB3 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 2 minutes

The following ADRB3 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

ADRB3 Antibodies

ADRB3 Proteins

ADRB3 Antibodies

ADRB3 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA007545	ADRB3 Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA779661	ADRB3 Antibody	Human	ELISA,IHC
CSB-PA120361	ADRB3 Antibody	Human	ELISA,IHC
CSB-PA235900	ADRB3 Antibody	Human,Mouse	ELISA,WB,IHC
CSB-PA831980	ADRB3 Antibody	Human	ELISA,WB,IHC
CSB-PA001393LA01HU	ADRB3 Antibody	Human	ELISA, IF

ADRB3 Proteins

ADRB3 Proteins for Meriones unguiculatus (Mongolian jird) (Mongolian gerbil)

Code	Product Name	Source
CSB-CF001393MRA	Recombinant Meriones unguiculatus Beta-3 adrenergic receptor (ADRB3)	in vitro E.coli expression system
CSB-YP001393MRA1 CSB-EP001393MRA1 CSB-BP001393MRA1 CSB-MP001393MRA1 CSB-EP001393MRA1-B	Recombinant Meriones unguiculatus Beta-3 adrenergic receptor (ADRB3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ADRB3 Proteins for Cavia porcellus (Guinea pig)

Code	Product Name	Source
CSB-CF723311GU	Recombinant Guinea pig Beta-3 adrenergic receptor (ADRB3)	in vitro E.coli expression system
CSB-YP723311GU1 CSB-EP723311GU1 CSB-BP723311GU1 CSB-MP723311GU1 CSB-EP723311GU1-B	Recombinant Guinea pig Beta-3 adrenergic receptor (ADRB3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ADRB3 Proteins for Felis catus (Cat) (Felis silvestris catus)

Code	Product Name	Source
CSB-CF890583CA	Recombinant Cat Beta-3 adrenergic receptor (ADRB3)	in vitro E.coli expression system
CSB-YP890583CA1 CSB-EP890583CA1 CSB-BP890583CA1 CSB-MP890583CA1 CSB-EP890583CA1-B	Recombinant Cat Beta-3 adrenergic receptor (ADRB3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ADRB3 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-CF001393MO	Recombinant Mouse Beta-3 adrenergic receptor (Adrb3)	in vitro E.coli expression system
CSB-YP001393MO1 CSB-EP001393MO1 CSB-BP001393MO1 CSB-MP001393MO1 CSB-EP001393MO1-B	Recombinant Mouse Beta-3 adrenergic receptor (Adrb3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ADRB3 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-CF001393RA	Recombinant Rat Beta-3 adrenergic receptor (Adrb3)	in vitro E.coli expression system
CSB-YP001393RA1 CSB-EP001393RA1 CSB-BP001393RA1 CSB-MP001393RA1 CSB-EP001393RA1-B	Recombinant Rat Beta-3 adrenergic receptor (Adrb3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ADRB3 Proteins for Capra hircus (Goat)

Code	Product Name	Source
CSB-CF893613GO	Recombinant Goat Beta-3 adrenergic receptor (ADRB3)	in vitro E.coli expression system
CSB-YP893613GO1 CSB-EP893613GO1 CSB-BP893613GO1 CSB-MP893613GO1 CSB-EP893613GO1-B	Recombinant Goat Beta-3 adrenergic receptor (ADRB3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ADRB3 Proteins for Ovis aries (Sheep)

Code	Product Name	Source
CSB-CF896433SH	Recombinant Sheep Beta-3 adrenergic receptor (ADRB3)	in vitro E.coli expression system
CSB-YP896433SH1 CSB-EP896433SH1 CSB-BP896433SH1 CSB-MP896433SH1 CSB-EP896433SH1-B	Recombinant Sheep Beta-3 adrenergic receptor (ADRB3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ADRB3 Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-CF001393BO	Recombinant Bovine Beta-3 adrenergic receptor (ADRB3)	in vitro E.coli expression system
CSB-YP001393BO1 CSB-EP001393BO1 CSB-BP001393BO1 CSB-MP001393BO1 CSB-EP001393BO1-B	Recombinant Bovine Beta-3 adrenergic receptor (ADRB3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ADRB3 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

Code	Product Name	Source
CSB-CF001393DO	Recombinant Dog Beta-3 adrenergic receptor (ADRB3)	in vitro E.coli expression system
CSB-YP001393DO1 CSB-EP001393DO1 CSB-BP001393DO1 CSB-MP001393DO1 CSB-EP001393DO1-B	Recombinant Dog Beta-3 adrenergic receptor (ADRB3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ADRB3 Proteins for Sus scrofa (Pig)

Code	Product Name	Source
CSB-CF846459PI	Recombinant Pig Beta-3 adrenergic receptor (ADRB3)	in vitro E.coli expression system
CSB-YP846459PI1 CSB-EP846459PI1 CSB-BP846459PI1 CSB-MP846459PI1 CSB-EP846459PI1-B	Recombinant Pig Beta-3 adrenergic receptor (ADRB3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ADRB3 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-CF001393HU	Recombinant Human Beta-3 adrenergic receptor (ADRB3)	in vitro E.coli expression system
CSB-YP001393HU1 CSB-EP001393HU1 CSB-BP001393HU1 CSB-MP001393HU1 CSB-EP001393HU1-B	Recombinant Human Beta-3 adrenergic receptor (ADRB3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-MP001393HU	Recombinant Human Beta-3 adrenergic receptor (ADRB3)-VLPs	Mammalian cell

ADRB3 Proteins for Macaca mulatta (Rhesus macaque)

Code	Product Name	Source
CSB-CF630685MOW	Recombinant Macaca mulatta Beta-3 adrenergic receptor (ADRB3)	in vitro E.coli expression system
CSB-YP630685MOW1 CSB-EP630685MOW1 CSB-BP630685MOW1 CSB-MP630685MOW1 CSB-EP630685MOW1-B	Recombinant Macaca mulatta Beta-3 adrenergic receptor (ADRB3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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ADRB3

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