AKT2

AKT2, or protein kinase Bβ, is a serine/threonine kinase that plays an important role in intracellular signalling.AKT2 is expressed predominantly in insulin-sensitive tissues such as skeletal muscle, adipose and liver, and is a key component of the PI3K/AKT signalling pathway. Its mechanism of action involves the production of PIP3 by PI3K, which recruits AKT2 to the cell membrane and activates AKT2 by phosphorylation.Activated AKT2 is able to phosphorylate a variety of substrates, including FOXO transcription factors, mTOR complex, etc., thus regulating cell growth, metabolism, survival and apoptosis.AKT2 is involved in signalling pathways including insulin signalling pathway, IGF-1 signalling pathway, etc. These pathways include insulin signaling pathway, IGF-1 signaling pathway, etc., which is a key component of PI3K/AKT signalling pathway. AKT2 is involved in insulin signalling pathway, IGF-1 signalling pathway, etc., which play a central role in the regulation of cellular nutrient uptake and utilisation as well as energy homeostasis, etc.

AKT2 is also closely related to the regulation of the cell cycle, cellular stress response and cell migration. In a biological sense, AKT2 is essential for maintaining normal physiological functions and metabolic homeostasis of cells. Its aberrant activation is associated with the development of metabolic diseases and tumours such as type 2 diabetes, obesity and certain types of cancer, and is a potential target in the treatment of these diseases.