||Highly selective and weak inward-rectifying potassium channel. Plays a role in both loading and unloading potassium into/from the phloem sap. Seems to control sugar loading into phloem via a voltage-dependent process. Blocked by physiological concentrations of external calcium and by external acidification. May interact with the cytoskeleton or with regulatory proteins. Dephosphorylation by PP2CA not only leads to the inhibition of potassium currents but also to an increase of the voltage-dependence of the channel. Regulated by the CBL4/CIPK6 calcium sensor/protein kinase complex via a kinase interaction-dependent but phosphorylation-independent translocation of the channel to the plasma membrane.
|Gene References into Functions
- the outward-rectifying potassium-selective channel GORK limits the action potential amplitude and duration, while the weakly-rectifying channel AKT2 affects membrane excitability. PMID: 29561764
- AKT2 subunit containing K(+) channels mediate sodium chloride-induced depolarization of root cells. PMID: 27043750
- CBL4 together with the interacting protein kinase CIPK6 modulates the activity and plasma membrane targeting of the K(+) channel AKT2. PMID: 21445098
- Data discuss the existence of multiple post-translational modification steps that work in concert to convert AKT2 from an inward-rectifying into a non-rectifying K (+) channel. PMID: 21445013
- the AKT2/3 subunit constitutes the Ca2+ sensitivity of the guard cell K+ uptake channel PMID: 15824192
- The role of 2 phosphorylation sites on the switch between gating modes of AKT2 are described. PMID: 16297070
- AKT2-transformed tobacco mesophyll cells displayed inward-rectifying, rather than voltage-independent K+ channels. PMID: 17146665
||Endoplasmic reticulum membrane, Multi-pass membrane protein
||Potassium channel family, Plant (TC 1.A.1.4) subfamily
||Expressed mainly in the phloem tissues throughout the plant but also, at a lower level, in leaf epiderm, mesophyll and guard cells.