Serine-protein kinase ATM is a protein in humans that is encoded by ATM gene. Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes.
ATM Antibodies for Homo sapiens (Human)
|Code||Product Name||Species Reactivity||Application|
ATM Proteins for Homo sapiens (Human)
ATM Proteins for Mus musculus (Mouse)
ATM Proteins for Sus scrofa (Pig)
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