CSF2RB

Colony-stimulating Factor 2 Receptor Beta (CSF2RB) is a transmembrane protein that constitutes the common beta chain (hβc) of cytokines IL-3, IL-5 and GM-CSF receptor. CSF2RB is required for high-affinity ligand binding and signal transduction.

CSF2RB is expressed in cells of neutrophils, eosinophils and basophils. The pleiotropic cytokines interleukins IL-3, IL-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF) plays critical and overlapping roles in the differentiation and function of myeloid cells. They are important mediators of host defense and innate immunity, while also significantly contributing to the development and progression of inflammatory pathologies. Studies have found that CSF2RB is mainly studied in blood system diseases, which not only promotes the proliferation and differentiation of hematopoietic cells, but also plays an important role in maintaining the balance of hematopoietic cell proliferation, differentiation and self-renewal.

Popular Product

Recombinant Human Cytokine receptor common subunit beta(CSF2RB), partial (Active) (CSB-MP006047HU)

Validated Data

Purity determined
by SDS-PAGE

Greater than 95% as determined by SDS-PAGE.

The binding activity of antigen-antibody validated by functional ELISA

Immobilized CSF2RB at 2 μg/ml can bind anti-CSF2RB antibody (CSB-RA006047A0HU), the EC₅₀ is 0.1594-0.3046 ng/mL.