CSF2RB

CSF2RB encodes the colony-stimulating factor 2 receptor beta subunit (CD131), a shared component of receptors for GM-CSF, IL-3, and IL-5. It forms heterodimeric complexes with ligand-specific alpha subunits to initiate signal transduction, supporting hematopoietic cell proliferation, differentiation, and survival of myeloid lineages.
Its signaling activates JAK2/STAT5, MAPK/ERK, and PI3K/Akt pathways. Dysregulation links to myeloproliferative neoplasms, allergic eosinophilia, and autoimmune diseases. Therapeutically, anti-GM-CSF receptor antibodies targeting CSF2RB are in clinical trials for rheumatoid arthritis and asthma, while small-molecule inhibitors are explored for hematological malignancies.