Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
C chemokine receptor type 4 (CCR4), also known as CD194, belongs to the G protein-coupled receptor family. CCR4 is mainly expressed in various lymphocytes and tissues. As an important chemokine receptor, CCR4 binds to the chemokine ligands and performs its function in human autoimmune diseases, such as atopic dermatitis (AD), asthma, and cutaneous T-cell lymphoma (CTCL). CCR4 was originally noted that chemokines were important in the inflammatory response.
There are various chemokines identified as CCR4 ligands, including CCL17, CCL22, RANTES, MCP-1, MIP-1α, and the newest ligand CKLF1. At present, accumulated research suggested that chemokines in combination with their receptors play a key role in the tumor cells infiltration, distant metastasis, and other biological behaviors. CCR4 as a key chemokine receptor in tumor metastasis, several studies have demonstrated that high CCR4 expression is closely associated with poor prognosis in hematological and solid tumors. Collectively, CCR4 is expected to be a new therapeutic target for cancer immunotherapy.
Current studies have focused on the interaction between CCR4 and the high-affinity ligands CCL17 and CCL22. CCL17, also known as thymic activation regulatory chemokine (TARC), is expressed mainly in the thymus and other tissues such as lung, colon, and small intestine. CCL22 often named macrophage-derived chemokine (MDC), is mainly produced by dendritic cells and macrophages, which plays an important role in regulating the differentiation and proliferation of T lymphocytes, B lymphocytes, and dendritic cells by binding to the cell surface receptor CCR4.
More Interesting read related CCR4>>
● Recombinant Human C-C chemokine receptor type 4(CCR4)-VLPs (Active) (CSB-MP004843HU)
Validated Data
Immobilized Human CCR4 at 10 μg/ml can bind Anti-CCR4 recombinant antibody (CSB-RA004843MA01HU), the EC50 is 362.3-630.8 ng/mL.
The presence of VLP-like structures was confirmed by TEM
● Recombinant Human C-C chemokine receptor type 4(CCR4) (Active) (CSB-CF004843HU)
Validated Data
Greater than 85% as determined by SDS-PAGE.
Immobilized Human CCR4 at 5 μg/ml can bind Anti-CCR4 recombinant antibody (CSB-RA004843MA01HU), the EC50 is 7.818-21.25 ng/mL.
The following Ccr4 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
Ccr4 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA005336 | CCR4 Antibody |
Human,Mouse,Rat | WB, ELISA |
| CSB-PA006992 | CCR4 Antibody |
Human,Mouse,Rat | IF, ELISA |
| CSB-PA004843LA01HU | CCR4 Antibody |
Human | ELISA, IHC, IF |
| CSB-RA004843MA01HU | CCR4 Recombinant Monoclonal Antibody |
Human | ELISA, FC |
Ccr4 Antibodies for Arabidopsis thaliana (Mouse-ear cress)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA866940XA01DOA | CCR4 Antibody |
Arabidopsis thaliana | ELISA, WB (ensure identification of antigen) |
Ccr4 Antibodies for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA959115XA01SVG | CCR4 Antibody |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | ELISA, WB (ensure identification of antigen) |
Ccr4 Antibodies for Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA751781XA01DOT | CCR4 Antibody |
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) | ELISA, WB (ensure identification of antigen) |
Ccr4 Antibodies for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA527967XA01SXV | ccr4 Antibody |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) | ELISA, WB (ensure identification of antigen) |
Ccr4 Proteins for Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP373023AVC CSB-EP373023AVC CSB-BP373023AVC CSB-MP373023AVC CSB-EP373023AVC-B |
Recombinant Aspergillus clavatus Glucose-repressible alcohol dehydrogenase transcriptional effector (ccr4), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Ccr4 Proteins for Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP373090NEZ CSB-EP373090NEZ CSB-BP373090NEZ CSB-MP373090NEZ CSB-EP373090NEZ-B |
Recombinant Neosartorya fischeri Glucose-repressible alcohol dehydrogenase transcriptional effector (ccr4), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Ccr4 Proteins for Aspergillus niger (strain CBS 513.88 / FGSC A1513)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP382681AVE CSB-EP382681AVE CSB-BP382681AVE CSB-MP382681AVE CSB-EP382681AVE-B |
Recombinant Aspergillus niger Glucose-repressible alcohol dehydrogenase transcriptional effector (ccr4), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Ccr4 Proteins for Enterocytozoon bieneusi (strain H348) (Microsporidian parasite)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP488323EMA CSB-EP488323EMA CSB-BP488323EMA CSB-MP488323EMA CSB-EP488323EMA-B |
Recombinant Enterocytozoon bieneusi Probable glucose-repressible alcohol dehydrogenase transcriptional effector homolog (CCR4) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Ccr4 Proteins for Nosema ceranae (strain BRL01) (Microsporidian parasite)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP505300NHO CSB-EP505300NHO CSB-BP505300NHO CSB-MP505300NHO CSB-EP505300NHO-B |
Recombinant Nosema ceranae Probable glucose-repressible alcohol dehydrogenase transcriptional effector homolog (CCR4) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Ccr4 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP527967SXV CSB-EP527967SXV CSB-BP527967SXV CSB-MP527967SXV CSB-EP527967SXV-B |
Recombinant Schizosaccharomyces pombe Glucose-repressible alcohol dehydrogenase transcriptional effector (ccr4), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Ccr4 Proteins for Aspergillus terreus (strain NIH 2624 / FGSC A1156)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP607711APT CSB-EP607711APT CSB-BP607711APT CSB-MP607711APT CSB-EP607711APT-B |
Recombinant Aspergillus terreus Glucose-repressible alcohol dehydrogenase transcriptional effector (ccr4), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Ccr4 Proteins for Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP609913EUG CSB-EP609913EUG CSB-BP609913EUG CSB-MP609913EUG CSB-EP609913EUG-B |
Recombinant Phaeosphaeria nodorum Glucose-repressible alcohol dehydrogenase transcriptional effector (CCR4), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Ccr4 Proteins for Coccidioides immitis (strain RS) (Valley fever fungus)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP625614DUV CSB-EP625614DUV CSB-BP625614DUV CSB-MP625614DUV CSB-EP625614DUV-B |
Recombinant Coccidioides immitis Glucose-repressible alcohol dehydrogenase transcriptional effector (CCR4), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Ccr4 Proteins for Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP652755DPA CSB-EP652755DPA CSB-BP652755DPA CSB-MP652755DPA CSB-EP652755DPA-B |
Recombinant Aspergillus oryzae Glucose-repressible alcohol dehydrogenase transcriptional effector (ccr4), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Ccr4 Proteins for Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP681250NGS CSB-EP681250NGS CSB-BP681250NGS CSB-MP681250NGS CSB-EP681250NGS-B |
Recombinant Neosartorya fumigata Glucose-repressible alcohol dehydrogenase transcriptional effector (ccr4), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Ccr4 Proteins for Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP685477CZD CSB-EP685477CZD CSB-BP685477CZD CSB-MP685477CZD CSB-EP685477CZD-B |
Recombinant Candida albicans Glucose-repressible alcohol dehydrogenase transcriptional effector (CCR4), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Ccr4 Proteins for Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP685553EKF CSB-EP685553EKF CSB-BP685553EKF CSB-MP685553EKF CSB-EP685553EKF-B |
Recombinant Emericella nidulans Glucose-repressible alcohol dehydrogenase transcriptional effector (ccr4), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Ccr4 Proteins for Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP700033UBS CSB-EP700033UBS CSB-BP700033UBS CSB-MP700033UBS CSB-EP700033UBS-B |
Recombinant Ustilago maydis Glucose-repressible alcohol dehydrogenase transcriptional effector (CCR4), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Ccr4 Proteins for Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP731895DIS CSB-EP731895DIS CSB-BP731895DIS CSB-MP731895DIS CSB-EP731895DIS-B |
Recombinant Debaryomyces hansenii Glucose-repressible alcohol dehydrogenase transcriptional effector (CCR4), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Ccr4 Proteins for Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP731995YAP CSB-EP731995YAP CSB-BP731995YAP CSB-MP731995YAP CSB-EP731995YAP-B |
Recombinant Yarrowia lipolytica Glucose-repressible alcohol dehydrogenase transcriptional effector (CCR4), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Ccr4 Proteins for Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP732018KBK CSB-EP732018KBK CSB-BP732018KBK CSB-MP732018KBK CSB-EP732018KBK-B |
Recombinant Kluyveromyces lactis Glucose-repressible alcohol dehydrogenase transcriptional effector (CCR4), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Ccr4 Proteins for Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP739340CZI CSB-EP739340CZI CSB-BP739340CZI CSB-MP739340CZI CSB-EP739340CZI-B |
Recombinant Candida glabrata Glucose-repressible alcohol dehydrogenase transcriptional effector (CCR4), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Ccr4 Proteins for Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP751781DOT CSB-EP751781DOT CSB-BP751781DOT CSB-MP751781DOT CSB-EP751781DOT-B |
Recombinant Ashbya gossypii Glucose-repressible alcohol dehydrogenase transcriptional effector (CCR4), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Ccr4 Proteins for Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP823404EKH CSB-EP823404EKH CSB-BP823404EKH CSB-MP823404EKH CSB-EP823404EKH-B |
Recombinant Encephalitozoon cuniculi Probable glucose-repressible alcohol dehydrogenase transcriptional effector homolog (CCR4) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Ccr4 Proteins for Arabidopsis thaliana (Mouse-ear cress)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP866940DOA CSB-EP866940DOA CSB-BP866940DOA CSB-MP866940DOA CSB-EP866940DOA-B |
Recombinant Arabidopsis thaliana Serine/threonine-protein kinase-like protein CCR4 (CCR4), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Ccr4 Proteins for Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP880175NHA CSB-EP880175NHA CSB-BP880175NHA CSB-MP880175NHA CSB-EP880175NHA-B |
Recombinant Neurospora crassa Glucose-repressible alcohol dehydrogenase transcriptional effector (ccr-4), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Ccr4 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
| Code | Product Name | Source |
|---|---|---|
| CSB-CF839750DO | Recombinant Dog C-C chemokine receptor type 4 (CCR4) |
in vitro E.coli expression system |
| CSB-YP839750DO1 CSB-EP839750DO1 CSB-BP839750DO1 CSB-MP839750DO1 CSB-EP839750DO1-B |
Recombinant Dog C-C chemokine receptor type 4 (CCR4), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Ccr4 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-CF004843HU | Recombinant Human C-C chemokine receptor type 4 (CCR4) (Active) |
in vitro E.coli expression system |
| CSB-YP004843HU1 CSB-BP004843HU1 CSB-MP004843HU1 CSB-EP004843HU1-B |
Recombinant Human C-C chemokine receptor type 4 (CCR4), partial |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP004843HU1 | Recombinant Human C-C chemokine receptor type 4 (CCR4), partial |
E.coli |
| CSB-MP004843HU | Recombinant Human C-C chemokine receptor type 4 (CCR4)-VLPs (Active) |
Mammalian cell |
Ccr4 Proteins for Mus musculus (Mouse)
| Code | Product Name | Source |
|---|---|---|
| CSB-CF004843MO | Recombinant Mouse C-C chemokine receptor type 4 (Ccr4) |
in vitro E.coli expression system |
| CSB-YP004843MO1 CSB-EP004843MO1 CSB-BP004843MO1 CSB-MP004843MO1 CSB-EP004843MO1-B |
Recombinant Mouse C-C chemokine receptor type 4 (Ccr4), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
