CD74 is composed of a long N-terminal cytoplasmic tail and a short C-terminal extracellular domain, encompassing the NT, CLIP, and CY structural domains. It contains tyrosine/threonine signaling motifs within its intracellular region. CD74 serves as a transporter for MHC class II molecules, crucial for immune recognition of pathogens. It is found in B cells and certain T cells, participating in lymphoid development. CD74 activates signaling pathways such as ERK, PI3K, and NF-κB, and exhibits multiple isoforms, displaying complex regulatory functions. The existence of various isoforms of CD74 suggests that it may play specific roles in different cell types and under physiological or pathological conditions.
● Recombinant Human HLA class II histocompatibility antigen gamma chain (CD74), partial (Active)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD74 at 2 μg/ml can bind Anti-CD74 recombinant antibody (CSB-RA004956A1HU), the EC50 is 1.317-1.646 ng/mL.
● Recombinant Mouse H-2 class II histocompatibility antigen gamma chain (Cd74), partial
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP004956MO could indicate that this peptide derived from E.coli-expressed Mus musculus (Mouse) Cd74.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP004956MO could indicate that this peptide derived from E.coli-expressed Mus musculus (Mouse) Cd74.
The following Cd74 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
Cd74 Antibodies for Mus musculus (Mouse)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA004956LD01MO | Cd74 Antibody, Biotin conjugated |
Mouse | ELISA |
CSB-PA004956LA01MO | Cd74 Antibody |
Mouse | ELISA, WB |
Cd74 Antibodies for Rattus norvegicus (Rat)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA004956LA01RA | Cd74 Antibody |
Rat, Mouse | ELISA, WB |
Cd74 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA004956DSR1HU | CD74 Antibody |
Human | ELISA, IHC, IP |
CSB-PA005842 | CD74 Antibody |
Human | WB, ELISA |
CSB-RA004956A0HU | CD74 Recombinant Monoclonal Antibody |
Human | ELISA, IHC, FC |
CSB-RA004956A1HU | CD74 Recombinant Monoclonal Antibody |
Human | ELISA |
Cd74 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP004956RA CSB-BP004956RA CSB-MP004956RA CSB-EP004956RA-B |
Recombinant Rat H-2 class II histocompatibility antigen gamma chain (Cd74), partial |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP004956RA | Recombinant Rat H-2 class II histocompatibility antigen gamma chain (Cd74), partial |
E.coli |
CSB-CF004956RA | Recombinant Rat H-2 class II histocompatibility antigen gamma chain (Cd74) |
in vitro E.coli expression system |
Cd74 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP004956MO CSB-BP004956MO CSB-MP004956MO CSB-EP004956MO-B |
Recombinant Mouse H-2 class II histocompatibility antigen gamma chain (Cd74), partial |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP004956MO | Recombinant Mouse H-2 class II histocompatibility antigen gamma chain (Cd74), partial |
E.coli |
CSB-CF004956MO | Recombinant Mouse H-2 class II histocompatibility antigen gamma chain (Cd74) |
in vitro E.coli expression system |
Cd74 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-CF004956HU | Recombinant Human HLA class II histocompatibility antigen gamma chain (CD74) |
in vitro E.coli expression system |
CSB-YP004956HU1 CSB-BP004956HU1 CSB-MP004956HU1 CSB-EP004956HU1-B |
Recombinant Human HLA class II histocompatibility antigen gamma chain (CD74), partial |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP004956HU1 | Recombinant Human HLA class II histocompatibility antigen gamma chain (CD74), partial |
E.coli |
CSB-MP004956HU1(F2) | Recombinant Human HLA class II histocompatibility antigen gamma chain (CD74), partial (Active) |
Mammalian cell |
Cd74 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL004956HU | Human HLA class II histocompatibility antigen gamma chain(CD74) ELISA kit |
serum, plasma, tissue homogenates | 0.225 ng/mL |