Efna1 Research Reagents

Ephrin-A1 is a protein in humans that is encoded by EFNA1 gene. Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK.

The following Efna1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

Efna1 Antibodies

Efna1 Antibodies for Rattus norvegicus (Rat)

Efna1 Antibodies for Homo sapiens (Human)

Efna1 Proteins

Efna1 Proteins for Rattus norvegicus (Rat)

Efna1 Proteins for Homo sapiens (Human)

Efna1 Proteins for Mus musculus (Mouse)

Efna1 Proteins for Xenopus laevis (African clawed frog)

Efna1 Proteins for Bos taurus (Bovine)

Efna1 ELISA Kit

Efna1 ELISA Kit for Homo sapiens (Human)

Efna1 ELISA Kit for Mus musculus (Mouse)

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