HRAS

HRAS, a member of the RAS family alongside NRAS and KRAS, is encoded by the HRAS gene and functions as a membrane-associated GTP enzyme. This protein serves as a molecular switch, regulating cell growth, differentiation, and survival by binding to GTP or GDP, thus controlling cell signaling pathways. Abnormalities in HRAS, such as mutations or overexpression, are linked to the development of various cancers, including thyroid, salivary gland, bladder, cervical, and prostate cancers, highlighting its significant role in tumorigenesis.