Recombinant Mouse GTPase HRas (Hras1)

1. gene expression profiles of each of the Ras isoforms in a panel of mouse tissues derived from a full developmental time course, are reported. PMID: 28117393
2. This study demonstrates that H- ras deletion protects against AngII-induced cardiac remodeling, possibly via a mechanism in which PKG-Ibeta overexpression could play a partial role, and points to H-Ras and/or downstream proteins as potential therapeutic targets in cardiovascular disease. PMID: 29054855
3. HRas (G12V/G12V) mice showed robust upregulation of ERK signaling, neuronal hypertrophy, increased brain volume, spatial learning deficits, and impaired mGluR-dependent long-term depression (LTD). PMID: 28455524
4. the oncogenic Hras mutation modulates energy homeostasis in vivo. PMID: 29254681
5. Loss of wild-type Hras promotes the earliest stages of pancreatic tumorigenesis, and moreover results in more rapid progression of the disease. As such, mechanisms leading to activation of wild-type Ras proteins, including but not limited to redox-dependent reactions, may influence the development of pancreatic cancer. PMID: 28162272
6. High HRAS expression is associated with hepatocarcinogenesis. PMID: 28481866
7. this study shows that retinoic acid stabilizes HRas protein during neurogenesis. PMID: 27185863
8. we provide genetic evidence that the wild-type H-Ras and K-Ras proteins are bioequivalent in spite of their different structural and biological properties PMID: 27872088
9. loss of one allele of Hras increased the sensitivity of mice to this carcinogen, and this effect was further exacerbated by the loss of the second Hras allele. However, loss of one or both alleles of Nras failed to alter tumor burden, either in the absence or presence of Hras, after exposure to urethane. PMID: 27911940
10. H-ras isoform mediates protection against pressure overload-induced cardiac dysfunction in part through activation of AKT/PI3K signaling pathway. PMID: 28193718
11. The long intergenic non-coding RNA CCR492 functions as a let-7 competitive endogenous RNA to de-repress c-Myc expression and to promote cell transformation assisted by the constitutively active H-Ras. PMID: 27344374
12. these contrasting signatures precisely match those proposed to confer bias toward Hras(CAA61CTA) versus Braf(GTG636GAG) mutations in the original tumor sets. Our findings highlight a novel mechanism whereby exposure history acts through strand-biased mutagenesis to specify activation of preferred oncogenes PMID: 27207659
13. We find that the tumor suppressive effects of Hras are nullified in a homozygous mutant p53 background. As such, loss of wild-type Hras fosters the earliest stages of pancreatic cancer in a p53-dependent manner. PMID: 26452271
14. This study establishes a role for the loss of microRNA-203 in promoting selection and expansion of Hras mutated cells and identifies a mechanism through which microRNA-203 antagonizes Hras-mediated tumorigenesis. PMID: 26203562
15. The data suggest a role for redox-dependent activation of wild-type KRAS through cysteine 118 in oncogenic HRAS-driven tumorigenesis. PMID: 25902334
16. Phenotypic Screening Identifies Protein Synthesis Inhibitors as H-Ras-Nanocluster-Increasing Tumor Growth Inducers. PMID: 26568031
17. H-Ras mediates the inhibitory effect of epidermal growth factor on the epithelial Na+ channel PMID: 25774517
18. Conditional inactivation of p53 in urothelial cells of transgenic mice expressing mutant HRAS results in carcinoma in situ and basal-subtype muscle-invasive urothelial carcinomas of the bladder with focal squamous differentiation. PMID: 25795707
19. Hras allelic imbalance is an obligate step in papilloma development and occurs only at the papilloma stage. PMID: 24240680
20. the Arf-Egr-C/EBPbeta axis as an important determinant of cellular responses (senescence or transformation) to oncogenic Ras signaling PMID: 25535333
21. MicroRNA 17-92 cluster mediates ETS1 and ETS2-dependent RAS-oncogenic transformation PMID: 24968297
22. CARD9 regulates H-Ras activation by linking Ras-GRF1 to H-Ras, which mediates Dectin-1-induced extracellular signal-regulated protein kinase (ERK) activation and proinflammatory responses when stimulated by their ligands. PMID: 25267792
23. Data show that peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) promotes HRAS-induced senescence to inhibit tumorigenesis by potentiating p-ERK1/2 and repressing p-AKT signaling. PMID: 24213576
24. the function of the Ras pathway and its many effectors, including MAPK and PI3K, in the teeth of mice PMID: 24057668
25. These observations provide genetic evidence for an essential role of Ras proteins in the control of keratinocyte and epidermal proliferation. PMID: 23831572
26. Computational modeling revealed that complexes containing H-ras conformers and galectin-1 affect both the number and lifetime of nanoclusters and thus determine the specific Raf effector recruitment. PMID: 24569991
27. Positive feedback between PI3K and HRas is essential for fibroblasts to spontaneously self-organize and generate a productive migratory response in the absence of spatial cues. PMID: 23676667
28. Data indicate that Hras heterozygosity increases the rate of malignant progression of skin tumors. PMID: 22945650
29. we induced tumors in mice via the injection of transposons encoding three oncogenes(HRAS, c-Myc and shp53) and a plasmid-expressing transposase. PMID: 23380875
30. Results suggest L1-mediated signaling by the L1-ezrin-NF-kappaB pathway, that induces IGFBP-2 expression, has an important role in colorectal cancer progression. PMID: 22847612
31. These results show that CD8(+) T cells can orchestrate skin inflammation with psoriasis-like pathology in response to constitutive RAS activation in keratinocytes, and this is primarily mediated through IFN-gamma. PMID: 23151849
32. Oxidative stress differentially regulates the expression of Ha-Ras and Ki-Ras in cultured astrocytes. PMID: 23213349
33. ASPP2 modulates oncogenic RAS-induced autophagic activity to dictate the cellular response to RAS: to proliferate or senesce. PMID: 22847423
34. The findings revealed a novel mechanism by which PEA-15 positively regulates Ras/ERK signaling and increases the proliferation of H-Ras-transformed epithelial cells through enhanced phospholipase D1 expression and activation. PMID: 22105357
35. Upregulation of NKG2D ligands by H-RasV12 increased sensitivity of cells to NK cell-mediated cytotoxicity PMID: 22798674
36. H-Ras isoform is responsible for extracellular matrix synthesis, proliferation, and migration in fibroblasts. PMID: 22094331
37. disruption of the RP-Mdm2-p53 pathway by an Mdm2(C305F) mutation does not accelerate prostatic tumorigenesis induced by inactivation of the pRb family proteins (pRb/p107/p130) PMID: 21747916
38. these results suggest that the expression of H-ras12V oncogene leads to elevated levels of ROS and apolipoprotein A-I that contribute to steatosis. PMID: 21600874
39. we demonstrate for the first time that H-ras and N-ras act as critical controllers of Th1 responses PMID: 21444916
40. the activation of H-ras and N-ras isoforms does not play a major role in the early renal damage induced by unilateral ureteral obstruction PMID: 19288266
41. The activated CDK4 cooperates with the oncogenic HRAS(G12V) protein to increase the susceptibility of melanoma development in vivo.(Hras protein) PMID: 20703083
42. H-ras(G12V) expression also accelerated the increase following MD in the frequency of miniature excitatory potentials, mirroring accelerated plasticity in vivo. PMID: 20937865
43. Data suggest that constantly high Ras activity in differentiated neurons downregulates hippocampal precursor cell generation in the neuronal lineage, but is modulated by sex-dependent factors. PMID: 20398060
44. Data show that p66(Shc) coordinates Ras-dependent control of proliferation and anchorage sensation. PMID: 20676142
45. Ha-ras oncogene regulates morphogenesis, tumorigenesis, and metastasis through suppressing nm23 expression and modulation of immune cell function. PMID: 20944141
46. H-Ras and N-Ras have distinct functional roles during initial stages of the cell cycle PMID: 19895680
47. Ha-ras overexpression increases phosphorylation of Stat3 at serine-727 and tyrosine-705 in 293T cells and enhances oncogenicity of the cell. PMID: 19182994
48. Studies with transgenic mice expressing a constitutively active H-Ras suggest that despite the common origin of the lens & cornea, these 2 tissues possess distinct sets of downstream targets that regulate the cellular responses to Ras activation. PMID: 20105280
49. Using lung cell lines expressing oncogenic K-Ras, authors show that NF-kappaB is activated in these cells in a K-Ras-dependent manner and that NF-kappaB activation by K-Ras. PMID: 20406971
50. Angiotensin II-induced activation of c-Ret signaling with RAS is critical in ureteric bud branching morphogenesis PMID: 19961928

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KEGG: mmu:15461

STRING: 10090.ENSMUSP00000026572

UniGene: Mm.334313