IL3RA Antibodies for Homo sapiens (Human)
|Code||Product Name||Species Reactivity||Application|
IL3RA Proteins for Homo sapiens (Human)
|CSB-CF011658HU||in vitro E.coli expression system|
In Vivo Biotinylation in E.coli
IL3RA Proteins for Mus musculus (Mouse)
|CSB-CF011658MO||in vitro E.coli expression system|
In Vivo Biotinylation in E.coli
Interleukin-3 receptor alpha chain (IL3RA), also known as CD123 (Cluster of Differentiation 123), is one of the two subunits of heterodimeric human IL-3R . The IL-3 receptor was first described on murine bone marrow cells. IL3RA belongs to a member of the cytokine receptor superfamily  but is more closely related to the GM-CSF receptor alpha chain (GM-CSFRA) and IL-5RA chains . The expression of both IL3RA and beta subunit IL3RB, the other IL-3R chain, is necessary for triggering signalling and cellular proliferation in response to IL-3 . Human IL-3 induces heterodimerization of IL-3R alpha and beta subunit IL3RB and that disulfide linkage of these chains is involved in receptor activation but not high-affinity binding . Interaction between the human IL-3R and IL-3 triggers a variety of cellular signals leading to the preservation of cell viability, proliferation, and differentiation of hemopoietic cells against apoptosis . Yao Tong et al. revealed the IL3RA is targeted for ubiquitination and degradation by the E3 ligase RNFT2 (RING finger transmembrane-domain containing protein 2, also TMEM118) and identifyied IL3RA Lys357 as a critical residue regulating IL3RA stability . In vitro, IL3 promotes RNFT2-dependent IL3RA proteasomal degradation, an effect mitigated by LPS-priming. No mutations of the IL3RA gene have been reported in hematological and non hematological human malignancies . Increased IL3RA expression has been reported in about 45% of patients with acute myeloid leukemia  and in 40% of patients with acute B lymphoid leukemia.
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