LCK

Tyrosine-protein kinase Lck is a protein in humans that is encoded by LCK gene. Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway.

LCK Antibodies

LCK Antibodies for Homo sapiens (Human)

LCK Proteins

LCK Proteins for Gallus gallus (Chicken)

LCK Proteins for Mus musculus (Mouse)

LCK Proteins for Aotus nancymaae (Ma's night monkey)

LCK Proteins for Saimiri sciureus (Common squirrel monkey)

LCK Proteins for Homo sapiens (Human)

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