Recombinant Mouse Proto-oncogene tyrosine-protein kinase LCK (Lck)

1. Data show that protein tyrosine kinase p56(lck) (Lck) expression is higher in Th1 cells as compared to Th2 cells. PMID: 28539628
2. LCK nitration inhibits T cell activation, leading to reduced interleukin 2 (IL2) production and proliferation. PMID: 30232256
3. Mutation of the basic clusters in the CD28 cytoplasmic domain reduced the recruitment to the CD28-Lck complex of protein kinase Ctheta; (PKCtheta;), which serves as a key effector kinase in the CD28 signaling pathway. PMID: 27460989
4. A phosphosite within the SH2 Domain of Lck regulates its activation by CD45. A negative feedback loop that responds to signaling events tunes active Lck amounts and TCR sensitivity. PMID: 28735895
5. We show a striking 65% reduction in cellularity, preferential development of gammadelta versus alphabeta T cells, and increased expression of IL-7R in the thymus of mice expressing Cre under the proximal lck promoter (lck-cre(+) mice) PMID: 27503210
6. this work demonstrates a role for constitutive Lck activity in controlling antigen sensitivity PMID: 27271569
7. this study defines distinct and complementary requirements for proximal and distal lck promoters during T-cell development PMID: 27469439
8. Aurora A inhibition causes delocalized clustering of Lck at the immunological synapses and decreases its phosphorylation levels thus indicating Aurora A is required for maintaining Lck active during T-cell activation. PMID: 27091106
9. essential for thymic development in presence or absence of Cbl, ensuring MHC restriction of T cells PMID: 25477210
10. Lck-Dlx5 mice develop T-ALLs that consistently acquire overexpression of Myc and activation of Akt. PMID: 25793663
11. Lck-CD8 interaction is required for initial CD8 recruitment. PMID: 25427562
12. CD4 is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase p56lck PMID: 25829544
13. Study concludes that the intracellular state of Lck Study conclude that the intracellular state of Lck determines the specificity of thymic selection and that Lck association with coreceptor proteins during thymic selection is the mechanism by which MHC restriction is imposed on a randomly generated alphabetaTCR repertoire. PMID: 24034254
14. LCK could be considered a target attenuated by the anti-aging effects of CR. Integrative analysis of cDNA microarray and interactome data are powerful tools for identifying target molecules that are involved in the aging process and modulated by CR. PMID: 22828953
15. Mechanistically, poly-G oligonucleotides directly induce the phosphorylation of Lck (an essential element of the T cell-signaling pathway), thereby enhancing production of IL-2 and CD8 T cell proliferation. PMID: 23296706
16. Specific pharmacological inhibition and genetic silencing indicated the involvement of Lck in the regulation of neuritic outgrowth. PMID: 23007847
17. Data show that activation of both tuned and untuned CD4 single-positive (SP) thymocytes is Lck-dependent. PMID: 22529380
18. results show that Lck plays an essential role in PC in both cellular and animal models of stroke. PMID: 22623673
19. These data illustrate a lipid microdomain-based mechanism concentrating the preactivated pool of cellular Lck and supporting its high stoichiometry of colocalization with CD45 in CD4( ) T cells. PMID: 22281390
20. This result raises the possibility that oncogenic Lck may activate Lmo2 promoter through direct interaction. PMID: 22222369
21. Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling. PMID: 21917715
22. These findings reveal a novel mechanistic insight into how CD28 costimulation negatively regulates the generation of induced regulatory T cells. PMID: 21245484
23. Results suggest that RhoH regulates TCR signaling via recruitment of ZAP-70 and Lck to CD3zeta in the immunological synapse. PMID: 21103055
24. Lck signaling is required for centrosome docking at the immunological synapse. PMID: 21339332
25. Mislocalization of Lck impairs thymocyte differentiation and can promote development of thymomas. PMID: 20876849
26. Lower levels of Lck, a key kinase involved in T cell receptor triggering, result in CD4 T cells that with wild type CD8 T cells are better able to control tumor growth. PMID: 21048115
27. SOCS1 and SOCS3 expression attenuates Lck-mediated cellular transformation PMID: 20372794
28. p56lck is functionally and physically associated with CD4 and CD8 in normal T lymphocytes, where an independent signal is transduced by their interaction with major histocompatibility complex (MHC) determinants. PMID: 20724731
29. impairment of Lck-mediated CD4 coreceptor signaling by Nef is an important in vivo mechanism of HIV-1 pathogenesis PMID: 20826747
30. CD44 directly associates with Lck in a zinc-inducible manner and this is important for the transmission of CD44-mediated signaling events leading to T cell spreading. PMID: 20417561
31. results indicate that the cellular levels of Lck and Fyn play a role in regulating the strength of the gammadeltaTCR signaling response at different stages in the life of the gammadelta T cell PMID: 20126650
32. These results establish that SOCS-6 acts as a negative regulator of T cell activation by promoting ubiquitin-dependent proteolysis of p56(lck). PMID: 20007709
33. characterization of the in vivo sites of serine phosphorylation PMID: 11847223
34. Lck, a member of the Src family of tyrosine kinases, forms a functional signaling module with PKCepsilon PMID: 11854322
35. Long term survival of naive T cells requires a combination of signals transduced by Src family kinase member Lck (and Fyn) and signals through the IL-7 receptor. PMID: 12218114
36. we studied intracellular signaling in SMACs by three-dimensional immunofluorescence microscopic localization of CD3, CD45, talin, phosphotyrosine, Lck and phosphorylated ZAP-70 in T cell-APC conjugates PMID: 12244310
37. CD8(+) T cell can engage two or three targets, a synapse occurs at the site of engagement and molecules involved in attachment (lymphocyte function-associated antigen 1), signaling (Lck) and lytic activity (perforin) are differentially positioned PMID: 12352968
38. Lck is needed for full, sustained activation of the tyrosine phosphorylation and MAP kinase cascades triggered by the BCR in CD5+, B-1 cells. Lck is involved in the higher activation threshold for productive BCR signaling in B-1 vs B-2 cells. PMID: 12645942
39. characterization of the interdependence of Lck and Fyn function and establish the spatial and temporal distinctions of their roles in the cellular activation process PMID: 12732664
40. the SD10 region in Lck, which is a novel site involved in substrate recognition, binds to CD45-D2 PMID: 14625311
41. Phosphorylation of Lck induced by partial T cell receptor agonist does not lead to activation of zeta-associated protein of 70 kDa, Ca+ mobilization or cytoskeletal reorganization, yet it is deemed sufficient to transduce a competence-to-die signal. PMID: 14734719
42. This study provides insight into the role of Lck as a mobile signaling element, whose subcellular localization indirectly predicates anti-T cell receptor (TCR)-mediated activation through its regulation of the function of colocalized Fyn. PMID: 15034040
43. Lck-Tert mouse lines showed higher incidences of spontaneous T-cell lymphoma than the corresponding age-matched wild-type controls, indicating that constitutive expression of Tert promotes lymphoma. PMID: 15121848
44. When signaling of naive T cells is restricted to the T cell antigen receptor, Fyn plays an essential role by positive regulation of Lck activity. PMID: 15465914
45. Tec vesicles have a membrane proximal location and overlap with the tyrosine kinase Lck, the Tec substrate PLC-gamma1, and the early endosomal antigen 1 marker EEA1 PMID: 15817477
46. B-1 cells expressed less Lck at both the protein and RNA levels than did B-2 cells. The same B-1 cells manifested defective BCR-mediated induction of IKKbeta phosphorylation, IkappaBalpha degradation, and intracellular Ca(2+) mobilization. PMID: 15972627
47. the Lck binding region of SLP-76 is essential for T cell antigen receptor signaling and normal T cell development and function PMID: 16354835
48. the cross-talk between Syk and Lck regulates hypoxia/reoxygenation-induced breast cancer progression PMID: 16474166
49. Results indicate that Lck SH3 domain function may provide a means to independently couple receptor signaling to regulation of the ERK pathway during thymocyte development. PMID: 16923964
50. Signals through Lck are essential for the development of T-cell-effector potential, particularly for effective cytokine transcription. PMID: 16966372

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KEGG: mmu:16818

STRING: 10090.ENSMUSP00000125777

UniGene: Mm.293753