Tumor necrosis factor receptor superfamily member 14 (TNFRSF14),also known as herpesvirus entry mediator (HVEM), is a receptor for BTLA, TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. The protein encoded by this gene is a member of the TNF-receptor superfamily. The cytoplasmic region of this receptor was found to bind to several TNF receptor associated factor (TRAF) family members, which may mediate the signal transduction pathways that activate the immune response. it is involved in lymphocyte activation, and plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.
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Validated Data
Greater than 93% as determined by SDS-PAGE.
Immobilized SIRPA (CSB-MP021334HU) at 2 μg/ml can bind human CD47, the EC50 of human CD47 protein is 65.91-82.42 ng/ml.
Human SIRPA protein His/Myc tag (CSB-MP021334HU) captured on COOH chip can bind Human CD47 protein Fc tag with an affinity constant of 19.1 nM as detected by LSPR Assay.
The following TNFRSF14 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
TNFRSF14 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
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CSB-YP842173HU CSB-EP842173HU CSB-BP842173HU CSB-EP842173HU-B |
Recombinant Human Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
CSB-AP002331HU | Recombinant Human Tumor necrosis factor receptor superfamily member 14 protein (TNFRSF14) | Yeast |
CSB-MP842173HU | Recombinant Human Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), partial (Active) | Mammalian cell |
TNFRSF14 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
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CSB-EL023973HU | Human Tumor necrosis factor receptor superfamily member 14(TNFRSF14) ELISA kit | serum, plasma, tissue homogenates | 3.9 pg/mL |