TNFRSF14

Tumor necrosis factor receptor superfamily member 14 (TNFRSF14),also known as herpesvirus entry mediator (HVEM), is a receptor for BTLA, TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. The protein encoded by this gene is a member of the TNF-receptor superfamily. The cytoplasmic region of this receptor was found to bind to several TNF receptor associated factor (TRAF) family members, which may mediate the signal transduction pathways that activate the immune response. it is involved in lymphocyte activation, and plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.

Most Popular Product:

Recombinant Human Tumor necrosis factor receptor superfamily member 14(TNFRSF14),partial (Active) (CSB-MP842173HU)

Validated Data

High Purity Validated by SDS-PAGE

Greater than 93% as determined by SDS-PAGE.

Excellent Bioactivity Validated by Functional ELISA

Immobilized SIRPA (CSB-MP021334HU) at 2 μg/ml can bind human CD47, the EC₅₀ of human CD47 protein is 65.91-82.42 ng/ml.

Excellent Bioactivity Validated by Functional ELISA

Human SIRPA protein His/Myc tag (CSB-MP021334HU) captured on COOH chip can bind Human CD47 protein Fc tag with an affinity constant of 19.1 nM as detected by LSPR Assay.