TNF Antibody

Datasheet

Code	CSB-PA523593ZA01MQG
Size	US$299
Image	Western Blot Positive WB detected in Recombinant protein All lanes: TNF antibody at 1:2000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 34.2 kDa Observed band size: 35 kDa
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Target Background

Product Details

Uniprot No.

O35734

Target Names

TNF

Alternative Names

Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form], TNF, TNFA TNFSF2

Species Reactivity

Marmota monax

Immunogen

Recombinant Marmota monax Tumor necrosis factor (TNF), partial (57-233aa)

Immunogen Species

Marmota monax

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Protein G

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

The TNF antibody is meticulously crafted through rabbit immunization with recombinant Marmota monax TNF (57-233aa), which triggers the production of tailored IgG antibodies by the rabbit's B lymphocytes. Afterward, the polyclonal TNF antibody is thoroughly purified from the rabbit's serum using protein G methods. This TNF antibody can bind to Marmota monax TNF protein in ELISA and WB tests.

Marmota monax tumor necrosis factor (TNF) protein is a cytokine involved in modulating the inflammatory response and immune defenses. TNF is rapidly upregulated when stimulated by inflammatory stimulation and binds to the TNF receptor, leading to NF-κB activation and IL6 production.

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Target Background

Function

Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6.; The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.

Subcellular Location

Cell membrane; Single-pass type II membrane protein.; [Tumor necrosis factor, membrane form]: Membrane; Single-pass type II membrane protein.; [Tumor necrosis factor, soluble form]: Secreted.; [C-domain 1]: Secreted.; [C-domain 2]: Secreted.

Protein Families

Tumor necrosis factor family

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Related pathways

MAPK signaling pathway mTOR signaling pathway TGF-beta signaling pathway NF-kappa B signaling pathway TNF signaling pathway Apoptosis Necroptosis Antigen processing and presentation Fc epsilon RI signaling pathway Hematopoietic cell lineage IL-17 signaling pathway Natural killer cell mediated cytotoxicity NOD-like receptor signaling pathway Osteoclast differentiation T cell receptor signaling pathway Toll-like receptor signaling pathway Adipocytokine signaling pathway AGE-RAGE signaling pathway in diabetic complications Inflammatory Pain

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TNF Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background