Code | CSB-PA325438XA01RA |
Size | Pls inquire |
Have Questions? | Leave a Message or Start an on-line Chat |
Full Product Name | Rabbit anti-Rattus norvegicus (Rat) Tnf Polyclonal antibody |
Uniprot No. | P16599 |
Target Names | Tnf |
Alternative Names | Tnf antibody; Tnfa antibody; Tnfsf2 antibody; Tumor necrosis factor antibody; Cachectin antibody; TNF-alpha antibody; Tumor necrosis factor ligand superfamily member 2 antibody; TNF-a) [Cleaved into: Tumor necrosis factor antibody; membrane form antibody; N-terminal fragment antibody; NTF); Intracellular domain 1 antibody; ICD1); Intracellular domain 2 antibody; ICD2); C-domain 1; C-domain 2; Tumor necrosis factor antibody; soluble form] antibody |
Raised in | Rabbit |
Species Reactivity | Rattus norvegicus (Rat) |
Immunogen | Recombinant Rattus norvegicus (Rat) Tnf protein |
Immunogen Species | Rattus norvegicus (Rat) |
Conjugate | Non-conjugated |
Clonality | Polyclonal |
Isotype | IgG |
Purification Method | Protein A/G |
Concentration | It differs from different batches. Please contact us to confirm it. |
Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Form | Liquid |
Tested Applications | ELISA, WB (ensure identification of antigen) |
Protocols | ELISA Protocol |
Troubleshooting and FAQs | Antibody FAQs |
Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
Value-added Deliverables | ① 200ug * antigen (positive control); ② 1ml * Pre-immune serum (negative control); |
Quality Guarantee | ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection; ② ELISA titer can be guaranteed 1: 64,000; ③ WB validation with antigen can be guaranteed positive; |
Lead Time | Made-to-order (14-16 weeks) |
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Function (From Uniprot) |
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6.; The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells. |
Subcellular Location | Cell membrane; Single-pass type II membrane protein.; [Tumor necrosis factor, membrane form]: Membrane; Single-pass type II membrane protein.; [Tumor necrosis factor, soluble form]: Secreted.; [C-domain 1]: Secreted.; [C-domain 2]: Secreted. |
Protein Families | Tumor necrosis factor family |
Database Links |
KEGG: rno:103694380 STRING: 10116.ENSRNOP00000001110 UniGene: Rn.2275 |