Mouse Interleukin-7,IL-7 ELISA kit

1. We engineered CAR-T cells to express interleukin (IL)-7 and CCL19 (7 x 19 CAR-T cells), as these factors are essential for the maintenance of T-cell zones in lymphoid organs... Following treatment of mice with 7 x 19 CAR-T cells, both recipient conventional T cells and administered CAR-T cells generated memory responses against tumors. PMID: 29505028
2. A key role of the IL7 and Interferon type I receptor axis in the regulation of intratumoral t-cell functions and in the development of primary breast tumor growth and metastasis. PMID: 29070614
3. BMP4 and IL7 appear to be involved in the interaction between intestinal epithelial cells and intestinal epithelial cells and in the mechanism underlying intestinal mucosal barrier dysfunction. PMID: 29436597
4. This finding warrants future development of IL-21 and IL-7 co-expressing whole-cell cancer vaccines and their relevant combinatorial regimens. PMID: 27571893
5. both Flt3 ligand (FL) and IL-7 regulate B-cell commitment in a permissive manner: FL by inducing proliferation of Ly6D(+)CD135(+)CD127(+)CD19(-) progenitors and IL-7 by providing survival signals to these progenitors PMID: 27911806
6. the in vivo biological role of m(6)A modification in T-cell-mediated pathogenesis and reveals a novel mechanism of T cell homeostasis and Il-7 signal-dependent induction of mRNA degradation PMID: 28792938
7. IL-7/IL-7R signaling pathway plays a possible role in recurrent pregnancy loss by upregulating Th17 immunity while downregulating Treg immunity. PMID: 27767237
8. this study shows that IL-7 homeostasis is achieved through consumption by multiple subsets of innate and adaptive immune cells PMID: 28723549
9. lymphatic vessel expansion occurs in two distinct phases; the first wave of expansion is dependent on IL-7; the second phase, responsible for leukocyte exit from the glands, is regulated by lymphotoxin (LT)betaR signaling PMID: 27474071
10. DNM2 mutations cooperate with Lmo2 T-cell oncogenes by enhancing IL-7 signalling. PMID: 27118408
11. IL-7 responsiveness in RTE is designed to maximize survival at the expense of reduced proliferation, consistent with RTE serving as a subpopulation of T cells rich in diversity but not in frequency. PMID: 27129922
12. Expression of IL-7 is beneficial for induction of potent and long-lasting humoral immune responses. PMID: 28100620
13. findings support a redundant role for adaptive Th17 cell- and innate gammadeltaT17 cell-derived IL17 in bacteria-induced colon carcinogenesis, stressing the importance of therapeutically targeting the cytokine itself rather than its cellular sources PMID: 26880802
14. functional Gimap5 is required for optimal signaling through TCR and IL-7R in T cells. PMID: 27023180
15. continuous IL7 signaling was not required for tumor regression, although LIP of naive CD8+ T cells is usually regulated by IL7 PMID: 26880265
16. IL7 represses the follicular helper T cell gene program. PMID: 26743592
17. This study uncovers the metabolic mechanisms by which IL-7 tailors the metabolism of memory T cells to promote their longevity and fast response to rechallenge. PMID: 25957683
18. IL-7 reduced IRAK-M expression and attenuated immune tolerance induced by either LPS or CpGA PMID: 26218271
19. Poly I:C induces IL-7 production, early inflammatory responses, and characteristic pathologies of SS-like dacryoadenitis in non-autoimmune-prone C57BL/6 mice. PMID: 26658504
20. Data show that interleukin 7 (IL-7) signaling is a prerequisite for optimal CD4(+) T cell activation. PMID: 26319414
21. reduced surface expression of IL-7R and concomitant limited responsiveness to IL-7 signals as a common mechanism resulting in reduced cell survival of common lymphoid progenitors and thymocytes at the double-negative to double-positive transition PMID: 26475928
22. Hair follicle expression of IL-7 was required for CD8+ and CD4+ skin-resident memory T (TRM) cells to exert tropism for the epidermis. In a cutaneous T cell lymphoma model, CD4+ TRM lymphoma cell localization depended on hair follicle-derived IL-7. PMID: 26479922
23. Data show the contribution of IL-23/IL-23 receptor and IL-7/IL-7 receptor signaling in Th17 and Th1 cell dynamics during experimental autoimmune encephalomyelitis (EAE). PMID: 26223651
24. IL-7 plays a major role in innate immunity against Citrobacter rodentium infection. PMID: 26034215
25. The effects of 6-formylindolo (3,2-b) carbazole (Ficz), a ligand of aryl hydrocarbon receptor, on IL-7 expression, colitis and lymphocyte phenotypes are reported. PMID: 25799939
26. IL-7 critically acts cooperatively with signaling via the pre-TCR and Notch1 to coordinate proliferation, differentiation and TCRalpha recombination during beta-selection. PMID: 25729925
27. The enhanced thymic reconstitution in the rIL-7/HGFbeta-treated allogeneic BMT recipients results in increased number and functional activities of peripheral T cells. PMID: 24349415
28. these results suggest that PU.1 and Spi-B activate Btk to oppose IL-7 responsiveness in developing B cells. PMID: 25505273
29. Results provided evidence that IL-7/IL-7R induce VEGF-D upregulation and promote lymphangiogenesis via c-Fos/c-Jun pathway in lung cancer. PMID: 24115038
30. OX40 and IL-7 play synergistic, but distinct roles in the homeostatic proliferation of CD4(+) effector memory T cells PMID: 25103720
31. IL-7 holds promise as a critical cytokine for selectively inducing Tfh cell generation. PMID: 24899182
32. NF-kappaB has a role in controlling IL-7 responsiveness of quiescent naive T cells PMID: 24799710
33. IL-12 induces the expression of IL-7 in microglia and macrophages via both IL-12Rbeta2 and IL-12Rbeta1. PMID: 24224652
34. Ikaros is a central regulator of IL-7 signaling and pre-B cell development PMID: 24297995
35. our data point toward an unexpected new role for IL-7 as a potential autocrine mediator of lymphatic drainage PMID: 23963040
36. KGF could up-regulate IL-7 expression through the STAT1/IRF-1, IRF-2 signaling pathway, which is a new insight in potential effects of KGF on the intestinal mucosal immune system. PMID: 23554911
37. -7 enhances the Th1 response to promote the development of Sjogren's syndrome-like autoimmune exocrinopathy in mice. PMID: 23666710
38. IRFs activated by lymphocyte adhesion induce IL-7 transcription through ISRE in stromal cells. PMID: 23376291
39. our results suggest that thymic epithelial cell-derived IL-7 plays a major role in proliferation, survival, and maturation of thymocytes and is indispensable for gammadelta T cell development PMID: 23686483
40. We have analyzed the discrete contributions of the antibody constant (Fc) and IL-7-binding (Fab) domains to the mechanism. PMID: 23610371
41. expression of IL-7/IL-7R is strongly correlated with rheumatoid arthritis activity and ligation of IL-7 to IL-7R contributes to monocyte homing, differentiation of osteoclasts, and vascularization in the collagen-induced arthritis effector phase. PMID: 23606539
42. IL-7 could be an important mediator in arthritic conditions PMID: 22676399
43. Cessation of the IL-7 response of pre-B cell signaling components is controlled via a cell-autonomous mechanism that operates at a discrete developmental transition marked by transient expression of c-Myc. PMID: 23420891
44. Interleukin-7, but not thymic stromal lymphopoietin, plays a key role in the T cell response to influenza A virus. PMID: 23189186
45. Interleukin-7 supports survival of T-cell receptor-beta-expressing CD4(-) CD8(-) double-negative thymocytes. PMID: 23215679
46. poly I:C boosts the T cell immune response in the lung by inducing local IL-7 production, which in turn, enhances T cell-derived IFN-gamma to promote macrophage recruitment, CXCR3 ligand expression, and T cell infiltration. PMID: 23271706
47. Data show that lymphatic endothelial cells (LECs) are a prominent source of IL-7 both in human and murine lymph nodes. PMID: 22955921
48. This is the first demonstration that high levels of IL-7 antagonize Notch-1 signaling and suggest that IL-7 may affect T- versus B-lineage choice in the thymus. PMID: 22899673
49. Although IL-7 is crucial for naive CD4+ T cell homeostatic proliferation in response to lymphopenia, it has minimal impact on the homeostatic proliferation of regulatory CD4+ (Treg) cells. PMID: 22933631
50. These observations establish a key role for IL-7 in the complex mechanisms by which immune mediators modulate metabolic functions. PMID: 22768283
51. Loss of total Bim in interleukin-7-deprived T-cells resulted in delayed apoptosis. PMID: 22728771
52. Topical cilomilast suppresses the generation of IL-17-associated immunity in experimental DED. PMID: 22577075
53. Interleukin-7 links T lymphocyte and intestinal epithelial cell homeostasis PMID: 22384106
54. JunD/AP-1-mediated gene expression promotes lymphocyte growth dependent on interleukin-7 signal transduction PMID: 22384197
55. We propose that activity of the IL-7/STAT5 pathway plays a critical protective role in pro-b cells development PMID: 22581861
56. we document a critical requirement for in vivo IL-7 in T cell maintenance and specifically in Foxp3(+) cell homeostasis. PMID: 22593613
57. SI-IEL and lamina propria lymphocytes do not express the receptor for IL-7 (IL-7Ralpha/CD127). PMID: 21928282
58. Different levels of IL-7 signalling in vivo evoked distinct molecular mechanisms to regulate homeostatic fitness. PMID: 21932447
59. Attenuation of IL-7 signaling resulted in upregulation of the transcription factors Foxo1 and Pax5 PMID: 22267219
60. IL-7 blocks the differentiation of double-negative 3 thymocytes to double-positive cells PMID: 21882187
61. IL-7 is critical for the development of the intrinsic function of marginal zone B cells PMID: 21873520
62. SOCS-1 inhibits IL-7 responses in pre-B cell lines PMID: 21873521
63. IL-7 is essential for normal development of Ly6D(+) common lymphoid progenitors and Ebf-1 is crucial for lineage restriction in early lymphoid progenitors. PMID: 21652681
64. matures suppressive CD127(+) forkhead box P3 (FoxP3)(+) T cells into CD127(-) CD25(high) FoxP3(+) regulatory T cells PMID: 21413939
65. Aging leads to a significantly altered composition of lymphocyte subsets, and the lack of IL-7 seems to accelerate this process. PMID: 21388913
66. cytokine IL-7 plays an important role in hypothalamic body weight regulation PMID: 20376352
67. Following syngeneic bone marrow transplantion, administration of hybrid IL-7/hepatocyte growth factorbeta chain supports rapid and complete regeneration of the thymus, reconstituting the naive T cell pool and its normally diverse receptor repertoire. PMID: 21209281
68. Following proliferation mediated by either self-peptide-histocompatibility (MHC) interaction alone or in combination with IL-7, this study finds that T cell reconstitution is most efficient in the presence of increased IL-7 availability. PMID: 21239710
69. Post-positive selection signaling by IL-7 through mitogen-activated protein kinase ERK5 leads to the expression of Kruppel-like factor KLF2 and resulting emigration of T cells from the thymus. PMID: 21187442
70. IL-7 drives Cdc25A-mediated T-cell proliferation, which prevents the nuclear translocation of Foxo1, leading to reduced expression of CD62L and the migration of T cells into circulation. PMID: 20831893
71. bone-invading cells express and produce IL-7, which is known to promote osteoclast activation and osteolytic lesions PMID: 20067635
72. IL7 and Kit signaling synergize in positively regulating lymphoid tissue cell numbers in lymph node (LN) anlage and in promoting LN organogenesis. PMID: 20709954
73. gammadelta T cells are actively involved in the generation of alphabetaTCR+IL-17+ T cells in uveitis PMID: 20375337
74. IL-7-dependent B cells are required for the response to pneumococcal polysaccharide in adults. PMID: 20505146
75. FLT3 and CD43 signaling pathways involve STAT5A via Fiz1 and Hipk2 in B lymphoblastic lymphomas. PMID: 20360400
76. our findings identify a negative feedback mechanism in which signals derived from TCRbeta-selected thymocytes modulate Thymic epithelial cell-dependent IL-7 expression PMID: 20439914
77. Exposure of CD4(+) T cells to IL-7 during priming results in an increased frequency of CD4(+) memory T cells. PMID: 20064560
78. the IL-7 signaling pathway regulates lymph node organogenesis by controlling the size of the hematopoietic lymphoid tissue inducer cell pool. PMID: 20207995
79. control of glycolysis by IL-7R may contribute to the well-described roles of IL-7 in T cell development, homeostatic proliferation, and survival. PMID: 20194717
80. analysis of a bacterial artificial chromosome (BAC) transgenic mouse expressing ECFP in the Il7 locus PMID: 19907640
81. Results demonstrated that utilizing nonlytic Fc-fused IL-7 (IL-7-Fc(m)) as a genetic adjuvant significantly enhanced not only CD4(+) but also CD8(+) T-cell responses. PMID: 19950168
82. Findings show that adult LTi-like cells require extrinsic signals from podoplanin(+) splenic stromal cells to survive and suggest that IL-7 is not necessary to mediate their survival in the adult spleen. PMID: 19950181
83. the maintenance of peripheral T cells by IL-7 occurs partly through inhibition of Bim activity at the posttranslational level. PMID: 19933849
84. STAT5 and IL-7 signaling control cell survival and the developmental ordering of immunoglobulin gene rearrangements PMID: 19946273
85. IL-7 regulates chromatin accessibility for V(D)J recombination by specifically altering histone acetylation within the T cell receptor gamma locus. PMID: 11714763
86. enhances the survival and maintains the size of naive T cells PMID: 11739504
87. IL7 activates the nuclear localizing signal in SHP-1, increasing nuclear localization of SHP-1, which, in turn, regulates nuclear signaling in cell growth. PMID: 11987243
88. role in regulating homeostatic proliferation of memory phenotype CD8+ cells in conjunction with IL-15 PMID: 12070280
89. overexpression leads to IL-15-independent generation of memory phenotype CD8+-T cells PMID: 12070281
90. PPBSF is the operative form of IL-7 that normally induces IL-7Ralpha(lo) pre-pro-B cells to proliferate and differentiate into IL-7Ralpha(hi) pro-B cells, which then proliferate and differentiate into pre-B cells on stimulation with monomeric IL-7. PMID: 12184921
91. The earliest step in B lineage differentiation from common lymphoid progenitors is critically dependent upon interleukin 7. PMID: 12208884
92. soluble factors produced by the thymic microenvironment affect the ability of pro-B cells to respond optimally to IL-7, constituting a specific inhibition of intrathymic B lymphopoiesis PMID: 12393710
93. IL-7 induces substantial expression of latent HIV while having minimal effects on the T-cell phenotype. PMID: 12438635
94. Increased production uncouples bone formation from bone resorption during estrogen deficiency PMID: 12464669
95. Before kappa chain rearrangement occurs, TRANCE together with IL-7 induces pre-B cells to proliferate and makes this rearrangement more efficient. PMID: 12548564
96. Transient IL-7/IL-7R signaling provides a mechanism for feedback inhibition of immunoglobulin heavy chain gene rearrangements. PMID: 12594950
97. Study with transgenic IL-7(-/-) mice reveal that although IL-7 is not required for TCR gamma delta cell proliferation, it is required to prolong the life span of mature TCR gamma delta cells. PMID: 12682238
98. Tyrosine phosphorylation of clathrin heavy chain was strongly induced by interleukin 7(IL-7). PMID: 14636898
99. the progeny derived from myeloid-biased hematopoietic stem cells failed to respond to IL-7 in vitro. PMID: 14976059
100. Pattern of sensitivity of developing thymocytes to IL-7 suggests a two-signal mechanism by which survival of thymocytes between the TCR beta-chain rearrangement process (beta-selection) and the positive selection checkpoint is governed. PMID: 15034036

Show More

Hide All

KEGG: mmu:16196

STRING: 10090.ENSMUSP00000126219

UniGene: Mm.3825