IL7

IL7, interleukin 7, alias IL-7, is a 25 kDa-sized soluble secretory protein encoded by the IL7 gene that is produced primarily in bone marrow stromal cells and is also expressed in a variety of tissues, including the thymus, lymph nodes, intestines, lungs, liver, and skin.The mechanism of action of IL7 is primarily through binding to its receptor IL-7R, a heterodimeric complex consisting of the IL-7R IL-7R is a heterodimeric complex composed of α and γ chains. When IL-7 binds to its receptor, it activates the JAK1, JAK3, and PI3K signaling pathways, which in turn activate AKT or STAT5, leading to changes in the expression of BCL-2 family members and promoting cell survival and proliferation.IL7 has a wide range of biological significance, which is crucial for the development of T cells and B cells, the differentiation and survival of naïve T cells, and the generation and maintenance of memory T cells. IL7 signaling plays an indispensable role in the development and maintenance of a wide range of immune cells and is essential for adaptive immunity and maintenance of immune homeostasis. In addition, IL7 has shown potential applications in tumor therapy, such as enhancing T cell-mediated anti-tumor immune responses.