Recombinant Human Cytotoxic T-lymphocyte protein 4(CTLA4),partial

In Stock
Code CSB-AP005231HU
Product Type Immune Checkpoint
Size US$65
Uniprot No. P16410
Lead Time 5-10 business days
Storage Buffer Lyophilized from a 0.2 μm filtered 1xPBS, pH 7.4
Alias Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; CTLA-4; CD152; CTLA4
Species Homo sapiens (Human)
Biological_Activity The ED50 as determined by its ability to bind Mouse B7-1 in functional ELISA is less than 20 ng/ml.
Purity Greater than 95% as determined by SDS-PAGE.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence KAMHVAQPAVVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLRAMDTGLYICKVELMYPPPYYLGIGNGTQIYVIDPEPCPDSD
Research Area Immunology
Source Mammalian cell
Gene Names CTLA4
Expression Region 36-161aa
Tag Info C-terminal 6xHis-tagged
Mol. Weight 14.3 kDa
Protein Description Extracellular Domain
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Function Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
Involvement in disease Systemic lupus erythematosus (SLE); Diabetes mellitus, insulin-dependent, 12 (IDDM12); Celiac disease 3 (CELIAC3); Autoimmune lymphoproliferative syndrome 5 (ALPS5)
Subcellular Location Cell membrane, Single-pass type I membrane protein
Tissue Specificity Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation.
Database Links

HGNC: 2505

OMIM: 109100

KEGG: hsa:1493

STRING: 9606.ENSP00000303939

UniGene: Hs.247824

Pathway T cell receptor signaling pathway

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