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| Code | CSB-PA05689D0Rb |
| Size | US$299 |
| Uniprot No. | P42574 |
| Immunogen | Recombinant Human Caspase-3 protein (29-175AA) |
| Raised in | Rabbit |
| Species Reactivity | Human |
| Tested Applications | ELISA |
| Relevance | Involved in the activation cascade of caspases responsible for apoptosis execution. |
| Form | Liquid |
| Conjugate | Biotin |
| Storage Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method | >95%, Protein G purified |
| Isotype | IgG |
| Clonality | Polyclonal |
| Alias | Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12], CASP3, CPP32 |
| Immunogen Species | Homo sapiens (Human) |
| Protocols | ELISA Protocol |
| Research Area | Cell Biology |
| Target Names | CASP3 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Function | Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. |
| Subcellular Location | Cytoplasm |
| Protein Families | Peptidase C14A family |
| Tissue Specificity | Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system. |
| Database Links |
HGNC: 1504 OMIM: 600636 KEGG: hsa:836 STRING: 9606.ENSP00000311032 UniGene: Hs.141125 |
| Pathway |
MAPK signaling pathway
p53 signaling pathway TNF signaling pathway Apoptosis IL-17 signaling pathway Natural killer cell mediated cytotoxicity AGE-RAGE signaling pathway in diabetic complications ER Stress pathway |
CASP3 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA004548GA01HU | CASP3 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA05689C0Rb | CASP3 Antibody, FITC conjugated | Human | ELISA |
| CSB-PA05689B0Rb | CASP3 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA240326 | CASP3 Antibody | Human | ELISA,WB |
| CSB-PA000003 | Cleaved-CASP3 (D175) Antibody | Human | WB,IHC,ELISA |
| CSB-PA000020 | CASP3 Antibody | Human,Monkey | WB,ELISA |
| CSB-PA000022 | Cleaved-CASP3 (D175) Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-PA001231 | CASP3 Antibody | Human,Mouse,Rat | WB,IHC,IF,ELISA |
| CSB-PA005133 | CASP3 Antibody | Human,Mouse,Rat | WB,IF,IHC,ELISA |
| CSB-PA060268 | Cleaved-CASP3 (D175) Antibody | Human | IHC,ELISA |
| CSB-PA060269 | Phospho-CASP3 (S150) Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
| CSB-MA080226 | CASP3 Monoclonal Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA080230 | CASP3 Antibody | Human | WB,IHC |
| CSB-PA423088 | CASP3 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA984107 | CASP3 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA786000 | CASP3 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA140280 | CASP3 Antibody | Human,Mouse,Rat | IHC,ELISA |
CASP3 Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA05689A0Rb | CASP3 Antibody | Human | ELISA, IHC, IF |
CASP3 Antibodies for
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA148736 | Cleaved-CASP3 (A175) Antibody | Human, Mouse, Rat | ELISA, WB, IHC |
| CSB-PA000004 | Cleaved-CASP3 (D175) Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
CASP3 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP004548HU CSB-BP004548HU CSB-MP004548HU |
Recombinant Human Caspase-3(CASP3),partial | Yeast Baculovirus Mammalian cell |
| CSB-EP004548HU | Recombinant Human Caspase-3(CASP3),partial,Escherichia Coli | E.coli |
CASP3 ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E08856h | Human Caspase 3,Casp-3 ELISA Kit | serum, plasma, cell lysates, tissue homogenates | 0.078 ng/mL |
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