DGKI Antibody

Code CSB-PA948225
Size US$297Purchase it in Cusabio online store
(only available for customers from the US)
Image
  • Western blot analysis of extracts from 293 cells, using DGKI antibody.
  • Immunofluorescence analysis of HeLa cells, using DGKI antibody.
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) DGKI Polyclonal antibody
Uniprot No. O75912
Target Names DGKI
Alternative Names DGKIDiacylglycerol kinase iota antibody; DAG kinase iota antibody; EC 2.7.1.107 antibody; Diglyceride kinase iota antibody; DGK-iota antibody
Raised in Rabbit
Species Reactivity Human,Rat
Immunogen Synthesized peptide derived from C-terminal of Human DGKI.
Immunogen Species Homo sapiens (Human)
Clonality Polyclonal
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Form Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications ELISA,WB,IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
IF 1:100-1:500
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has probably no preference for any of the diacylglycerols in terms of the acyl chain composition, especially for the acyl chain at the sn-2 position. By controlling the diacylglycerol/DAG-mediated activation of RASGRP3, negatively regulates the Rap1 signaling pathway. May play a role in presynaptic diacylglycerol/DAG signaling and control neurotransmitter release during metabotropic glutamate receptor-dependent long-term depression.
Gene References into Functions
  1. the DGKI methylation status identified 22% of poorly responding patients in the low-risk group PMID: 25233099
  2. Here, we report results from a fine-mapping approach involving linkage and association analysis in Finnish and German dyslexic cohorts. We restrict a candidate region to 0.3 Mb on chromosome 7q33. PMID: 21203819
Subcellular Location Cell projection, axon. Cell projection, dendrite. Cell junction, synapse, presynapse. Cell junction, synapse, postsynapse. Cell junction, synapse, postsynaptic density. Cell junction, synapse, synaptic cell membrane. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cytoplasm, cytosol. Nucleus.
Protein Families Eukaryotic diacylglycerol kinase family
Tissue Specificity Specifically expressed in brain and retina. In brain, highly expressed in hippocampus, caudate nucleus, occipital pole, cerebral cortex, and cerebellum. Also detected in kidney.
Database Links

HGNC: 2855

OMIM: 604072

KEGG: hsa:9162

STRING: 9606.ENSP00000288490

UniGene: Hs.242947

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