Your Good Partner in Biology Research
Your Good Partner in Biology Research
| Code | CSB-PA948225 |
| Size |
US$297Purchase it in Cusabio online store (only available for customers from the US) |
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| Full Product Name | Rabbit anti-Homo sapiens (Human) DGKI Polyclonal antibody | ||||||
| Uniprot No. | O75912 | ||||||
| Target Names | DGKI | ||||||
| Alternative Names | DGKIDiacylglycerol kinase iota antibody; DAG kinase iota antibody; EC 2.7.1.107 antibody; Diglyceride kinase iota antibody; DGK-iota antibody | ||||||
| Raised in | Rabbit | ||||||
| Species Reactivity | Human,Rat | ||||||
| Immunogen | Synthesized peptide derived from C-terminal of Human DGKI. | ||||||
| Immunogen Species | Homo sapiens (Human) | ||||||
| Clonality | Polyclonal | ||||||
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | ||||||
| Concentration | It differs from different batches. Please contact us to confirm it. | ||||||
| Form | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | ||||||
| Tested Applications | ELISA,WB,IF | ||||||
| Recommended Dilution |
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| Protocols | ELISA Protocol Western Blotting(WB) Protocol Immunofluorescence (IF) Protocol |
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| Troubleshooting and FAQs | Antibody FAQs | ||||||
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | ||||||
| Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
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| Function |
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has probably no preference for any of the diacylglycerols in terms of the acyl chain composition, especially for the acyl chain at the sn-2 position. By controlling the diacylglycerol/DAG-mediated activation of RASGRP3, negatively regulates the Rap1 signaling pathway. May play a role in presynaptic diacylglycerol/DAG signaling and control neurotransmitter release during metabotropic glutamate receptor-dependent long-term depression.
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| Gene References into Functions |
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| Subcellular Location | Cell projection, axon. Cell projection, dendrite. Cell junction, synapse, presynapse. Cell junction, synapse, postsynapse. Cell junction, synapse, postsynaptic density. Cell junction, synapse, synaptic cell membrane. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cytoplasm, cytosol. Nucleus. |
| Protein Families | Eukaryotic diacylglycerol kinase family |
| Tissue Specificity | Specifically expressed in brain and retina. In brain, highly expressed in hippocampus, caudate nucleus, occipital pole, cerebral cortex, and cerebellum. Also detected in kidney. |
| Database Links |
HGNC: 2855 OMIM: 604072 KEGG: hsa:9162 STRING: 9606.ENSP00000288490 UniGene: Hs.242947 |
