MAPK12 Antibody

1. Study established an important role of p38gamma MAPK in epithelial-mesenchymal transition (EMT) and identified a novel signaling pathway for p38gamma MAPK-mediated tumor promotion. p38gamma MAPK regulated miR-200b through inhibiting GATA3 by inducing its ubiquitination, leading proteasome-dependent degradation. PMID: 30251680
2. NMR Characterization of Information Flow and Allosteric Communities in the MAP Kinase p38gamma. PMID: 27353957
3. study revealed a molecular pathway consisting of BMI1, miRNA let-7i, and ERK3, which controls the migration of head and neck cancer cells, and suggests that ERK3 kinase is a potential new therapeutic target in head and neck cancers, particularly those with BMI1 overexpression. PMID: 28079973
4. There was significant association between p38gamma expression and esophageal squamous cell carcinoma clinical stage, lymph nodes metastases, and tumor volume. p38delta overexpression can promote tumorigenesis in nude mice model xenografted with Eca109 cells whose basal level of p38delta was stably over-expressed and p38gamma was stably knocked down. PMID: 26666822
5. This study reveals a novel pathway that directly links ErbB4 and p38gamma to the transcriptional machinery of NKx2.5-GATA4 complex which is critical for cardiomyocyte formation during mammalian heart development. PMID: 26418945
6. during interphase ERK3 is mainly resident in the nucleoplasm in association with ribonuclear proteins involved in early pre-mRNA splicing, it undergoes cell cycle-dependent redistribution and, during apoptosis PMID: 26708186
7. Taken together our data suggest that as cells initiate adhesion to matrix increasing levels of ERK3 at the cell periphery are required to orchestrate cell morphology changes which can then drive migratory behavior. PMID: 26588708
8. phosphorylation at Ser-118 is required for ER to bind both p38gamma and c-Jun, thereby promoting ER relocation from ERE to AP-1 promoter sites. PMID: 22399296
9. p38gamma mitogen-activated protein kinase regulates breast cancer cell motility and metastasis, in part, by controlling expression of the metastasis-associated small GTPase RhoC. PMID: 21862636
10. a new paradigm in which p38gamma actively regulates the drug-Topo IIalpha signal transduction, and this may be exploited to increase the therapeutic activity of Topo II drugs. PMID: 21878638
11. demonstrates that p38gamma MAPK is a promising target for the design of targeted therapies for basal-like breast cancer with metastatic characteristics and for overcoming potential resistance against the PARP inhibitor PMID: 21532888
12. The majority of p38gamma-depleted cells die at mitotic arrest or soon after abnormal exit from M-phase. PMID: 21172807
13. In response to hyperosmotic stress, p38 also regulates formation of complexes between hDlg and PSF. PMID: 20605917
14. PTPH1 plays a role in Ras-dependent malignant growth of colon cancer by a mechanism depending on its p38gamma-binding activity. PMID: 20332238
15. Cardiac expression and subcellular localization PMID: 11991731
16. IL-2 and polysaccharide K increased the expression of ERK3. PMID: 12536241
17. CRM1 binds to ERK3and promotes the cytoplasmic relocalization of ERK3. Enforced localization of ERK3 in the nucleus or cytoplasm markedly attenuates the ability of the kinase to induce cell cycle arrest in fibroblasts. PMID: 12915405
18. data suggest that p38gamma increases basal glucose uptake and decreases DNP- and contraction-stimulated glucose uptake, partially by affecting levels of glucose transporter expression in skeletal muscle PMID: 14592936
19. SAPK3 phosphorylates mitochondrial protein Sab PMID: 15158451
20. Data show that in response to radiation, MRK controls two independent pathways: the Chk2-Cdc25A pathway leading to cell cycle arrest and the p38gamma MAPK pathway. PMID: 15342622
21. hyperactive variants of p38alpha induce, whereas hyperactive variants of p38gamma suppress, activating protein 1-mediated transcription PMID: 17088247
22. Mapk14 antagonizes Mapk12 activity through c-jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response. PMID: 17724032
23. p38alpha and p38gamma are essential components of the signaling pathway that regulates the tumor-suppressing senescence response PMID: 19251701

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HGNC: 6874

OMIM: 602399

KEGG: hsa:6300

STRING: 9606.ENSP00000215659

UniGene: Hs.432642