Recombinant Macaca fascicularis Interleukin-4(IL4)


In Stock
Code CSB-YP301281MOV
Product Type Recombinant Protein
Size US$2959Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. P79339
Relevance Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages.
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP301281MOV could indicate that this peptide derived from Yeast-expressed Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) IL4.
  • Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP301281MOV could indicate that this peptide derived from Yeast-expressed Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) IL4.
Storage Buffer Tris-based buffer,50% glycerol
Alias B-cell stimulatory factor 1
Species Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Purity Greater than 90% as determined by SDS-PAGE.
Sequence HKCDITLQEIIKTLNSLTEQKTLCTKLTITDILAASKNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERLKTIMREKYSKCSS
Research Area Immunology
Source Yeast
Gene Names IL4
Protein Names Recommended name: Interleukin-4 Short name= IL-4Alternative name(s): B-cell stimulatory factor 1 Short name= BSF-1 Lymphocyte stimulatory factor 1
Expression Region 25-153aa
Tag Info N-terminal 6xHis-tagged
Mol. Weight 16.9kDa
Protein Description Full Length of Mature Protein
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages.
Subcellular Location Secreted
Protein Families IL-4/IL-13 family
Database Links

UniGene: Mfa.6178

Pathway Jak-STAT signaling pathway
PI3K-Akt signaling pathway
Fc epsilon RI signaling pathway
Hematopoietic cell lineage
IL-17 signaling pathway
T cell receptor signaling pathway
Th1 and Th2 cell differentiation
Th17 cell differentiation

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