Recombinant Human Catenin beta-1(CTNNB1)

1. CXC chemokine ligand 9 promotes the progression of diffuse large B-cell lymphoma in a beta-catenin-dependent manner. PMID: 30130730
2. Results suggest that epigenetic regulation of CTNNB1 may serve as a novel avenue to block colon cancer cell migration and invasion. PMID: 29923144
3. The results demonstrated that 2HF could inhibit EMT, and cell migration and invasion through the Wnt/bcatenin signaling pathway by suppressing GSK3b phosphorylation, betacatenin expression and transactivation. PMID: 30226607
4. Collectively, these studies suggested the cellular transcription factor beta-catenin stimulates productive herpes simplex virus 1infection, in part because VP16 enhances beta-catenin dependent transcription. PMID: 30077727
5. CTNNB1 mutations may be more related to tumorigenesis ( aldosterone-producing adenoma) rather than excessive aldosterone production PMID: 28102204
6. CTNNB1 mutations were found in 60% of Basal cell adenoma but not in basal cell adenocarcinoma. None of the tested cases had PIK3CA mutations. CTNNB1 mutation trended to be more common in those cases having a predominant tubular or tubulotrabecular patterns. PMID: 29224720
7. Data reveal that post-translational modifications of beta-catenin in the ubiquitin-proteasome pathway yield a truncated beta-catenin molecule containing a serine 552-phosphorylated core region without N and C termini. This proteolytic processing of beta-catenin is required for binding with TCF4 and subsequent transcriptional activation. PMID: 29330435
8. Results identify CTNNB1 as a Girdin-interacting protein. Girdin-depleted skin cancer cells displayed scattering and impaired E-cadherin-specific cell-cell adhesion. PMID: 30194792
9. the dysregulation of TET2/E-cadherin/beta-catenin regulatory loop is a critical oncogenic event in HCC progression PMID: 29331390
10. High CTNNB1 expression is associated with bladder cancer progression. PMID: 30015971
11. It has been found that miR-27a-3p modulated the Wnt/beta-catenin signaling pathway to promote epithelial-mesenchymal transition in oral squamous carcinoma stem cells by down-regulating SFRP1. PMID: 28425477
12. Beta-catenin pathway is activated by CBX8 in in hepatocellular carcinoma. PMID: 29066512
13. our data provide a novel evidence for the biological and clinical significance of SPAG5 as a potential biomarker, and we demonstrate that SPAG5-b-catenin-SCARA5 might be a novel pathway involved in hepatocellular carcinoma progression. PMID: 30249289
14. Results show that hypoxia enhanced nuclear accumulation and transcriptional activity of beta-catenin which promotes expression of EMT-related genes and eventually contributes to the metastatic process in lung cancer cells. PMID: 30396950
15. This study demonstrates that FOXC1 induces cancer stem cells (CSCs)-like properties in non-small cell lung cancer (NSCLC) by promoting beta-catenin expression. The findings indicate that FOXC1 is a potential molecular target for anti-CSC-based therapies in NSCLC PMID: 30189871
16. High TBL1XR1 expression indicates poor disease-free survival of stage I-III colorectal cancer patients; beta-catenin signaling is critical for TBL1XR1-mediated colorectal cancer cells oncogenicity. PMID: 28295012
17. Taking together, these results suggest that Wnt/beta-catenin signal pathway activation-dependent up-regulation of syncytin-1 contributes to the pro-inflammatory factor TNF-alpha-enhanced fusion between oral squamous cell carcinoma cells and endothelial cells. PMID: 28112190
18. The disassociation of the beta-catenin/E-cadherin complex in the osteoblast membrane under stretch loading and the subsequent translocation of beta-catenin into the nucleus may be an intrinsic mechanical signal transduction mechanism. PMID: 29901167
19. Aberrant CTNNB1 expression was seen in a substantial proportion of our hepatocellular carcinoma (HCC) cases. CTNNB1-positive HCC was associated with normal AFP levels, unicentric tumors, well-differentiated histology, and an unfavorable outcome. PMID: 30082549
20. Long noncoding RNA AFAP1-AS1 enhances cell proliferation and invasion in osteosarcoma through regulating miR-4695-5p/TCF4-beta-catenin signaling. PMID: 29901121
21. High CTNNB1 expression is associated with the recurrece of Adamantinomatous Craniopharyngiomas. PMID: 29625497
22. High CTNNB1 expression is associated with uterine fibroids. PMID: 29066531
23. The nucleus and/or cytoplasm expression of beta-catenin was associated with tumor progression and correlated overall survival of patients with ovarian cancer (OC). beta-catenin may be a possible potential prognostic biomarker for the patients with OC. [review] PMID: 30103006
24. In the two wild type (WT) cases, two novel alterations were detected: a complex deletion of APC and a pathogenic mutation of LAMTOR2. Focusing on WT DT subtype, deep sequencing of CTNNB1, APC and LAMTOR2 was conducted on a retrospective series of 11 WT DT using a targeted approach PMID: 29901254
25. DLX1 interacted with beta-catenin and enhanced the interaction between beta-catenin and TCF4 T-cell factor PMID: 29317218
26. Nuclear beta-catenin immunoreactivity with appropriate criteria may be helpful to distinguish basal cell adenocarcinoma (BCAC) from histologically similar tumors. However, a minor subset of adenoid cystic carcinoma (ACC) with nuclear beta-catenin expression require careful diagnosis. PMID: 29496310
27. High CTNNB1 expression is associated with metastasis in cholangiocarcinoma. PMID: 30193944
28. beta;-catenin directly interacts with the Cx43 carboxyl-terminal domain. PMID: 29882937
29. This study showed that beta-catenin expression was the most evident in the nucleus rather than in cytoplasm. PMID: 29297710
30. Nuclear beta-catenin accumulation in non-mitotic glioblastoma cells is due to a feed forward mechanism between DOCK4 and beta-catenin. PMID: 28925399
31. Study found that HIF1alpha overexpression led to an enhanced betacatenin nuclear translocation, while betacatenin silencing inhibited betacatenin nuclear translocation. The enhanced betacatenin nuclear translocation induced resulted in an enhanced cell proliferation and cell invasion, an altered cell cycle distribution, decreased apoptosis, and improved nonhomologous end joining repair under normal and irradiation cond... PMID: 29658569
32. our results demonstrated that miR-188 inhibits glioma cell proliferation by targeting beta-catenin PMID: 29268818
33. Marked upregulation of beta-catenin and its downstream targets effectively enhanced hepatosphere formation, with an associated induction of CD133, OCT4 and Sox2 expression and also caused an significant enhancement of HCC proliferation PMID: 29792038
34. Wnt/beta-catenin signaling pathway may play a significant role in the pathogenesis of preeclampsia by regulating the invasion and proliferation of trophoblast. PMID: 29603045
35. Associations between environmental variants together with single nucleotide polymorphisms (SNPs) of beta-catenin (ctnnb1) and lung cancer risk were analyzed using a logistic regression model. PMID: 29562493
36. that CTNNB1 is overexpressed and confers a poor prognosis in acute myeloid leukemia PMID: 29496308
37. High CTNNB1 expression is associated with cisplatin-resistance in non-small cell lung cancer. PMID: 30009824
38. beta-catenin immunopositivity is seen in majority of cases of sinonasal sarcoma PMID: 29566950
39. For the first time, we demonstrated that rather than excluding lymphocytes infiltration as reported in mela-noma, high levels of TILs were associated with beta-catenin overexpression in BC. PMID: 29286921
40. Study shows that apigenin-induced lysosomal degradation of beta-catenin in Wnt/beta-catenin signaling. PMID: 28337019
41. Used CRISPR-Cas9 technology to study effect of knockout of catenin beta 1 (CTNNB1) on cell behavior and signal pathways in HEK293 cells. Results showed knockout of CTNNB1 effected Wnt/beta-catenin signaling pathway and suppressed adhesion and proliferation of HEK 293T cells. PMID: 29249062
42. our results also revealed that lncRNA SNHG20 knockdown inhibited Wnt/b catenin signaling activity by suppressing beta-catenin expression and reversing the downstream target gene expression. Taken together, lncRNA SNHG20 plays an pivotal role in ovarian cancer progression by regulating Wnt/b-catenin signaling PMID: 29101241
43. Wnt3A regulates the expression of 1,136 genes, of which 662 are upregulated and 474 are downregulated in CCD-18Co cells. A set of genes encoding inhibitors of the Wnt/beta-catenin pathway stand out among those induced by Wnt3A, which suggests that there is a feedback inhibitory mechanism. PMID: 29044515
44. The aim of our study was to analyze the immunohistochemical expression of beta-catenin, E-cadherin and Snail, depending on clinico-morphological aspects of the laryngeal squamous cell carcinomas. Results revealed variable E-cadherin, beta-catenin and Snail expression, depending on differentiation degree and tumor stage. PMID: 29250652
45. In this study we showed that the activation of Wnt/beta-catenin pathway culminates in the upregulation of MGAT1 enzyme both at transcriptional and post-transcriptional levels. We also showed that overexpression of the beta-catenin gene (CTNNB1) increased the promoter activity of MGAT1. PMID: 29310626
46. CTNNB1 mutation is associated with acquired resistance to KIT inhibitor in metastatic melanoma. PMID: 28421416
47. three CTNNB1 SNPs were suggested to have the potential to be novel biomarkers for risk prediction of cancer in overall population or some specific subgroups. [Review] PMID: 28963373
48. A CTNNB1 exon 3 mutation restricted to the areas exhibiting both positive glutamine synthetase (GS) and C-reactive protein (CRP) expression, whereas wild-type CTNNB1 was found in areas showing only CRP staining. These two cases illustrate focal beta-catenin activation that can occur within Inflammatory hepatocellular adenoma (IHCAs). PMID: 28618047
49. Results show that E-cadherin/beta-catenin complex is disrupted by ICAT promoting epithelial-mesenchymal transition of cervical cancer cells. PMID: 29048651
50. Toosendanin administration inhibited growth and liver metastasis of orthotopically implanted SGC7901 tumors in vivo through miR200amediated beta-catenin pathway. Our data suggest that Toosendanin may suppress oncogenic phenotypes of human GC cells partly via miR200a/beta-catenin axis. Hence, Toosendanin may have a promising chemotherapeutic activity for GC therapy. PMID: 29048657
51. High CTNNB1 expression is associated with papillary thyroid carcinoma. PMID: 28677753
52. we found that CypA binds beta-catenin and is recruited to Wnt target gene promoters. By increasing the interaction between beta-catenin and TCF4, CypA enhances transcriptional activity. Our results demonstrate that CypA enhances GIC stemness, self-renewal, and radioresistance through Wnt/beta-catenin signaling PMID: 28790108
53. Treatment of a xenograft model of a CTNNB1-mutant cell line with the TTK inhibitor NTRC 0066-0 resulted in complete inhibition of tumor growth. Mutations in CTNNB1 occur at relatively high frequency in endometrial cancer and hepatocellular carcinoma, which are known to express high TTK levels. We propose mutant CTNNB1 as a prognostic drug response biomarker, enabling the selection of patients most likely to respond to TTK PMID: 28751540
54. results indicated that miR-590-3p activates the Wnt/beta-catenin signaling pathway PMID: 29164578
55. High CTNNB1 expression is associated with cervical cancer tumorigenesis and metastasis. PMID: 28627610
56. using a xenograft mouse model, baicalin markedly reduced liver and lung metastasis of breast cancer, inhibited expression of beta-catenin, and degraded the EMT molecules vimentin and Slug in the orthotopic tumor tissues. Taken together, all these results indicate that baicalin effectively suppresses the metastasis of breast cancer by reversing EMT, which may be mediated by downregulation of beta-catentin expression. PMID: 29039569
57. miRNA-200a inhibits TGF beta1-induced EMT by directly targeting beta-catenin in proximal tubule epithelial cells PMID: 28817830
58. miR214 was demonstrated to directly interact with the 3'untranslated region of the betacatenin gene CTNNB1, and suppressed Wnt/betacatenin signaling through the inhibition of betacatenin. PMID: 29152645
59. Beta-catenin-mediated signaling regulates cancer cell metabolism and is associated with tumor-initiating cells in multiple malignancies. (Review) PMID: 29229887
60. Our results, for the first time, demonstrate repurposing potential of ormeloxifene as an anticancer drug for the treatment of advanced stage metastatic prostate cancer through a novel molecular mechanism involving beta-catenin and EMT pathway. PMID: 28615299
61. Mutations of catenin beta 1 (CTNNB1) in exon 3 (coding for beta-catenin) are observed in 10 to 15% of Hepatocellular Adenoma. PMID: 28733222
62. The data suggest that Med19 expression correlates with aggressive characteristics of bladder cancer, and Med19 knockdown suppresses the proliferation and migration of cancer cells through down-regulating the Wnt/beta-catenin pathway. PMID: 28631286
63. The formation of the beta-catenin/TCF4 complex was disrupted by HI-B1 due to the direct interaction of HI-B1 with beta-catenin. Colon cancer patient-derived xenograft (PDX) studies showed that a tumor with higher levels of beta-catenin expression was more sensitive to HI-B1 treatment, compared to a tumor with lower expression levels of beta-catenin PMID: 29033371
64. Data show that alteration in beta-catenin expression, a core component of the CDH17/beta-catenin axis, in tumors affects serine peptidase inhibitor Kazal type 1 (SPINK1) serum levels in hepatocellular carcinoma (HCC) patients. PMID: 28631187
65. Subsequent experiments documented that activation of EGFR signaling induced by PD98059 increased the amount of beta-catenin in the nucleus. Taken together, our findings may elucidate a possible mechanism explaining the ineffectiveness of MEK inhibitors in breast cancer treatment and improve our understanding of the role of MEK in cancer PMID: 29048617
66. Although Genome-Wide Association studies have not been carried out in the field of alcohol-related hepatocellular carcinoma (HCC), common single nucleotide polymorphisms conferring a small increase in the risk of liver cancer risk have been identified. Specific patterns of gene mutations including CTNNB1, TERT, ARID1A and SMARCA2 exist in alcohol-related HCC. [review] PMID: 28296015
67. PAK1 expression, evaluated by immunohistochemistry, was positively correlated with pERK and beta-catenin expression in lung tumors. Patients with high-PAK1, high-pERK, and high-nuclear beta-catenin tumors more frequently showed an unfavorable response to cisplatin-based chemotherapy when compared to their counterparts. PMID: 27713506
68. We conclude that a combined analysis of beta-catenin and p53 could have prognostic importance as markers for predicting the progression of colorectal cancer and contribute to the identification of patients with a high risk of mortality PMID: 29146051
69. This study demonstrated that Desmoid-type fibromatosis carrying T41A or S45F mutations and WT beta-catenin are two distinct molecular subgroups with regard to beta-catenin stability, alpha-catenin affinity, and gene expression profiling. PMID: 28627792
70. Odd-skipped related 1 (OSR1) downregulated the activity of the Wnt signaling pathway by suppressing the expression of sex-determining region Y-box 9 (SOX9) and beta-catenin. PMID: 29660200
71. Data show that plakoglobin interacted with p53R175H and decreased beta-catenin protein levels. PMID: 29660231
72. beta-Catenin is important in the pathogenesis of salivary gland pleomorphic adenomas and adenoid cystic carcinomas PMID: 29577164
73. These results suggested that increased ANXA2 and less expressed beta-catenin were correlated to adenomyosis-associated dysmenorrhea PMID: 28547742
74. report two cases of melanocytic tumors with features of "pure" atypical deep-penetrating nevus (e.g., without a common nevus component), with only a CTNNB1 mutation without mutations in the MAPK pathway PMID: 29086002
75. USP7 depletion in APC-mutated colorectal cancer inhibits Wnt activation by restoring beta-catenin ubiquitination, drives differentiation, and suppresses xenograft tumor growth. PMID: 29045831
76. This review will focus on the molecular mechanisms by which Wnt proteins modulate beta-catenin cytoplasmic levels and the relevance of this pathway for the development and cancer. PMID: 28844868
77. Nuclear expression of non-phospho beta-catenin might more appropriately reflect the biological behavior of desmoid-type fibromatosis (DF), and immunohistochemical staining with non-phospho beta-catenin could serve as a more useful diagnostic and prognostic tool of COX-2 inhibitor therapy for patients with DF. PMID: 28851389
78. A correlation between KIF3A loss and a poorer NSCLC prognosis as well as beta-catenin and cyclin D1 upregulation further suggests that KIF3A suppresses Wnt/beta-catenin signalling and tumourigenesis in NSCLC PMID: 27596264
79. triptonide can effectively inhibit canonical Wnt/beta-catenin signaling by targeting the downstream C-terminal transcription domain of beta-catenin or a nuclear component associated with beta-catenin PMID: 27596363
80. HIF-1alpha, which suppressed miR-340-5p promoter activation through HRE motifs, was induced by FA. The induction of b-catenin signaling by FA was consistent with an enhancement in osteogenesis of FA-treated MSC, which could be attenuated by miR-340-5p overexpression. Analysis of the signaling networks induced by FA reveals that hypoxia may promote the osteogenic program in mesenchymal stem cells via a novel microRNA pa... PMID: 28764862
81. High Expressions of CTNNB1 is associated with cancer. PMID: 28418856
82. TRIM65 exerted oncogenic activities via ubiquitylation of Axin1 to activate the beta-catenin signaling pathway. PMID: 28754688
83. study to identify the incidence of BRAF and CTNNB1 gene mutations in craniopharyngiomas and correlate it with clinicopathological parameters including histopathology, immunohistochemical expression of proteins BRAF pVal600Glu and beta-catenin and clinical outcome PMID: 28500561
84. PKC-zeta may be responsible for the abnormal growth, proliferation, and migration of metastatic LOVO colon cancer cells via PKC-zeta/Rac1/Pak1/beta-Catenin pathway. PMID: 29408512
85. High CTNNB1 expression is associated with colorectal cancer. PMID: 28373572
86. CSN5 can decrease beta-catenin ubiquitination to enhance the protein expression of SCARA5 in HCC cells. PMID: 29189991
87. Keap1 silencing in melanocytes induced melanogenesis and the expression of melanogenesis-associated molecules through HO-1-associated beta-catenin activation. Keap1 downregulation in melanocytes is important for cell proliferation and survival. PMID: 28583303
88. our results suggest that the amount of APC expression is the rate-limiting factor for the constitution of beta-catenin destruction complexes. PMID: 28810742
89. CFTR stabilizes beta-catenin and prevents its degradation, defect of which results in the activation of NF-kappaB-mediated inflammatory cascade PMID: 27588407
90. Epigenetic silencing of miR-338 facilitates glioblastoma progression by preventing suppression the PKM2/beta-catenin axis. PMID: 28858851
91. High expression of CTNNB1 is associated with epithelial-mesenchymal transition and invasion of pancreatic cancer. PMID: 28586066
92. HIV and drug abuse mediate astrocyte senescence in a beta-catenin-dependent manner leading to neuronal toxicity. PMID: 28612507
93. Muclear pbeta-cateninS552 staining discriminates between patients with inflammation and those with a history of low grade dysplasia, suggesting that nuclear pbeta-cateninS552 staining may reflect local expansions of activated stem cells with neoplastic potential. PMID: 28811707
94. miR-1301 inhibits hepatocellular carcinoma cell migration, invasion, and angiogenesis by decreasing Wnt/beta-catenin signaling through targeting BCL9. PMID: 28817119
95. Nuclear expression of beta-catenin in advanced ovarian cancer of long-term survival patients proved to be not only an independent favourable predictor of overall survival, but also showed strong correlation with platinum sensitivity and platinum re-induction PMID: 28651933
96. A correlation was found between stage, tumor differentiation grade, risk for relapse or progression of disease, and the impaired expression of different EMT markers: total or partial loss of E-cadherin expression, beta-catenin reorganization in cell-cell contacts, and a change in the ratio of cytoplasmic actin isoforms in the late stages of colon adenocarcinomas development. PMID: 28418353
97. Nuclear beta-catenin accumulation may contribute to chemoradioresistance in locally advanced rectal cancer PMID: 28370249
98. Activation of Wnt/beta-catenin signaling is required for TGF-beta/Smad2/Smad3 signaling during myofibroblast proliferation. PMID: 28244647
99. When considering endometrioid tumors of all grades and stages, CTNNB1 mutant tumors were associated with significantly higher rates of grades 1-2 disease, lower rates of deep myometrial invasion, and lower rates of lymphatic/vascular space invasion. PMID: 28281553
100. findings demonstrated that reduced membranous E-cadherin and aberrant beta-catenin expression were frequent events in SRCCs of various organs, and that the altered beta-catenin expression was significantly associated with advanced disease PMID: 26808130

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HGNC: 2514

OMIM: 114500

KEGG: hsa:1499

STRING: 9606.ENSP00000344456

UniGene: Hs.476018