Recombinant Mouse Moesin (Msn)

1. Collectively, these results implicate both moesin and myosin IIA in the regulation of phagolysosome biogenesis and in host defense against infections. PMID: 29247647
2. these findings underscore the importance of moesin in IL-15-dependent CD8+ Treg cell homeostasis and the control of self-tolerance PMID: 28978692
3. Moesin is an important regulator of the surface abundance and stability of TbetaRII and is important in facilitating the efficient generation of iTregs. PMID: 28287407
4. The expression of moesin was upregulated in cardiomyocytes under inflammation, inducing protrusion formation in a phosphorylation-dependent fashion. PMID: 27342875
5. These results of this study may pave the way for exploiting moesin as a novel target for intervention in muscular dystrophy. PMID: 28082118
6. this study shows that low neutrophil rolling in inflamed venules was impaired in moesin-deficient mice PMID: 27131737
7. High blood moesin levels were also observed in cecal ligation and puncture (CLP)-induced sepsis in mice. Administration of blocking moesin antibodies attenuated CLP-induced septic death. PMID: 25947626
8. An increase in moesin expression may contribute to the increased expression of P-gp in blood brain barrier endothelial cells, leading to the development of morphine analgesic tolerance. PMID: 25048710
9. phosphorylation-regulated interaction between the cytoplasmic tail of cell polarity protein crumbs and the actin-binding protein moesin PMID: 25792740
10. both moesin-mediated inhibition and its localized deactivation by myosin phosphatase are essential for neutrophil polarization and effective neutrophil tracking of pathogens. PMID: 25601651
11. A novel role for moesin in regulating clathrin-dependent S1PR1 internalization through clathrin-coated vesicles formation. PMID: 24358210
12. Moesin may be a potential drug target for inhibiting corneal fibrosis, and the details of moesin-related signaling pathways would be critical for understanding corneal fibrosis. PMID: 23583046
13. Findings indicate a function of moesin in lymphocyte homeostasis in regulating lymphocyte egress from lymphoid organs. PMID: 22875842
14. A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells. PMID: 23063725
15. the extracellular matrix molecule VN and its neuronal receptor TLCN play a pivotal role in the phosphorylation of ezrin/radixin/moesin proteins and the formation of phagocytic cup-like structures on neuronal dendrites PMID: 23019340
16. Ezrin/radixin/moesin are required for the purinergic P2X7 receptor (P2X7R)-dependent processing of the amyloid precursor protein. PMID: 22891241
17. increased moesin expression promotes EMT by regulating adhesion and contractile elements for changes in actin filament organization. PMID: 22031288
18. biomarker for the assessment of genotoxic carcinogens in lymphoma PMID: 22358511
19. Moesin is involved in AGE-induced retinal vascular endothelial dysfunction and the phosphorylation of moesin is triggered via ROCK and p38 MAPK activation. PMID: 21327982
20. The ERM (ezrin, radixin, moesin) proteins are novel scaffolds at the level of SOS activity control, which is relevant for both normal Ras function and dysfunction known to occur in several human cancers. PMID: 22132106
21. ezrin-radixin-moesin (ERM) proteins are induced in activated microglia/macrophages, whereas ERM molecules are only marginally expressed in quiescent microglia in the normal brain. PMID: 21451358
22. Ezrin, radixin, and moesin are phosphorylated in response to 2-methoxyestradiol and modulate endothelial hyperpermeability. PMID: 21659656
23. Results show that while CD43 binding to ezrin-radixin-moesin proteins is crucial for S76 phosphorylation, CD43 movement and regulation of T-cell migration can occur through an ERM-independent, phosphorylation-dependent mechanism. PMID: 21289089
24. Data suggest that myosin-II and ERM proteins modulate mechanical properties in oocytes, contributing to cell polarity and to completion of meiosis. PMID: 20660156
25. Data show that TNF-alpha induces the formation of fibrotic foci by cultured retinal pigment epithelial cells through activation of transforming growth factor-TGF-beta signaling in a manner dependent on hyaluronan-CD44-moesin interaction. PMID: 19965872
26. cross talk between the blastocyst and uterus involving the ezrin/radixin/moesin (ERM) proteins and ERM-associated cytoskeletal cross-linker proteins CD43, CD44, ICAM-1, and ICAM-2. PMID: 14613898
27. The study demonstrates a link between Galpha13 signaling that regulates differentiation of F9 cells through primitive to parietal endoderm and a moesin requirement for cell survival. PMID: 16860319
28. Ezrin/radixin/moesin proteins are activated by osmotic shrinkage in a PtdIns(4,5)-P(2)-dependent manner. PMID: 17977945
29. These data identify the ERM proteins, which cross-link the plasma membrane and actin, as major and stable cytoskeletal-associated proteins in lens fibers, and indicate a potential role(s) for the ERMs in fiber cell actin cytoskeletal organization. PMID: 18261459
30. Hepatic stellate cell migration and fibrogenesis in moesin-deficient mice, is described. PMID: 18606220
31. This is the first report of a functional involvement of moesin in the regulation of lung inflammation and repair, which regulates the preservation of alveolar structure and lung homeostasis. PMID: 18658275
32. These studies identify a new ERM kinase of importance in lymphocytes and confirm the role of ezrin-radixin-moesin phosphorylation in regulating cell shape and motility. PMID: 19255442
33. argue for ezrin-radixin-moesin proteins being both targets and modulators of parvovirus infection PMID: 19321616
34. These results suggest a critical role of moesin phosphorylation in Advanced glycation end products-induced endothelial cell functional and morphological regulations PMID: 19395553

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KEGG: mmu:17698

STRING: 10090.ENSMUSP00000113071

UniGene: Mm.138876