Tumor Necrosis Factor (TNF)Fig.1 The structure of TNF Tumor necrosis factor was reported firstly by Lloyd J. Old as one kind of cytotoxic factor produced by macrophages, from Memorial Sloan-Kettering Cancer Center, New York, in 1975. ...
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The Memory thief - Alzheimer's diseaseIn 1906, Dr. Alzheimer observed distinctive plaques and neurofibrillary tangles in the brain tissues of a woman who suffered from memory loss, language problems, and unpredictable behaviors during her illness until her d...
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Itaconate is a negative regulator of inflammationGlucose metabolite reduces inflammation A new study suggests that a glucose metabolite called itaconate functions as a negative regulator of macrophages (a type of immune cells). Macrophages can cause infla...
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Aesthetic Appreciation of Apoptosis Signal PathwayApoptosis is mediated primarily through promoting or inhibiting the activation of caspases. Caspases are effectors of cell suicide and cleave multiple substrates, leading to biochemical and morphological changes includin...
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Inhibition of ASCT2 combats cancer in vitro and in vivoNovel target for anti-cancer therapy Cancer cell metabolism is different from normal cell metabolism. This difference offers targets for the development of therapeutics to treat cancer. Cell function is dep...
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Apoptosis mediated by death receptor1. Apoptosis instruction 2. Pathways 2.1 Endogenous mitochondrial pathway 2.2 Endogenous endoplasmic reticulum pathway 2.3 Exogenous death receptor pathway Death receptor (DR) ...
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Apoptosis mediated by endoplasmic reticulum1. Apoptosis instruction 2. Pathways 2.1 Endogenous mitochondrial pathway 2.2 Endogenous endoplasmic reticulum pathway Endoplasmic reticulum(ER) is the main site of protein processing, as w...
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Apoptosis mediated by mitochondria 1. Apoptosis instruction Apoptosis is a genetically determined process of cell self-destruction to maintain its own internal environment under physiological or pathological conditions, while it is accompanied by...
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FAP may be a drug target for pancreatic cancerNovel drug target for pancreatic cancer Fibroblast activation protein (FAP) may be a novel drug target for pancreatic cancer, according to a study (Fibroblast activation protein augments progression and met...
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11 tips for choosing your right ELISA kitThe enzyme-linked immunosorbent assay (ELISA), sometimes referred to as enzyme immunoassay (EIA), is a popular, simple, and cost-effect detection technique. It uses enzymes and antibodies or antigens to identify a substa...
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