The Overview of Colony Stimulating FactorsColony stimulating factors (CSFs) are glycoproteins that bind to receptor proteins on the surfaces of hemopoietic stem cells, activating intracellular signaling pathways, then promoting production of white blood cells (m...
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The Overview of ChemokineChemokines are a series of cytokines with small molecular weight whose main role is the recruitment of leukocyte subsets under homeostatic and pathological conditions. Their name is derived from their ability to induce d...
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Protein Tags: A Comprehensive OverviewProteins play important roles in biological processes, drug discovery and development, disease diagnosis and treatment, and bioengineering and biotechnology. The importance and wide application of proteins make almost al...
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CUSABIO's Five Expression Systems1. What are CUSABIO's Five Expression Systems? Over more than 18 years, CUSABIO Protein Expression Platform has established five recombinant expression systems, which includes Escherichia coli (E.coli) expressio...
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Tumor Necrosis Factor (TNF)Fig.1 The structure of TNF Tumor necrosis factor was reported firstly by Lloyd J. Old as one kind of cytotoxic factor produced by macrophages, from Memorial Sloan-Kettering Cancer Center, New York, in 1975. ...
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The Memory thief - Alzheimer's diseaseIn 1906, Dr. Alzheimer observed distinctive plaques and neurofibrillary tangles in the brain tissues of a woman who suffered from memory loss, language problems, and unpredictable behaviors during her illness until her d...
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Itaconate is a negative regulator of inflammationGlucose metabolite reduces inflammation A new study suggests that a glucose metabolite called itaconate functions as a negative regulator of macrophages (a type of immune cells). Macrophages can cause infla...
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Aesthetic Appreciation of Apoptosis Signal PathwayApoptosis is mediated primarily through promoting or inhibiting the activation of caspases. Caspases are effectors of cell suicide and cleave multiple substrates, leading to biochemical and morphological changes includin...
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Inhibition of ASCT2 combats cancer in vitro and in vivoNovel target for anti-cancer therapy Cancer cell metabolism is different from normal cell metabolism. This difference offers targets for the development of therapeutics to treat cancer. Cell function is dep...
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Apoptosis mediated by death receptor1. Apoptosis instruction 2. Pathways 2.1 Endogenous mitochondrial pathway 2.2 Endogenous endoplasmic reticulum pathway 2.3 Exogenous death receptor pathway Death receptor (DR) ...
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