AKT3 Antibodies for Homo sapiens (Human)
|Code||Product Name||Species Reactivity||Application|
|CSB-PA15929A0Rb||Human, Mouse||ELISA, IP|
AKT3 Proteins for Rattus norvegicus (Rat)
In Vivo Biotinylation in E.coli
AKT3 Proteins for Mus musculus (Mouse)
In Vivo Biotinylation in E.coli
The AKT3 gene directs the generation of RAC-gamma serine/threonine-protein kinase (AKT3), which mediates many processes including metabolism, proliferation, cell survival, growth, and angiogenesis through serine and/or threonine phosphorylation of a range of downstream substrates. The encoding gene of AKT3 produces two almost identical variants via differential splicing of C-terminal exons, making AKT3 distinguishes from the otherwise similar AKT1 and AKT2 . AKT3 is a key regulator in the PI3K-AKT-mTOR pathway. Studies have shown that AKT3 is closely associated with the progression of several tumor types especially melanomas, accompanied by widespread PTEN mutations . Downregulated microRNA-217 promotes the occurrence and progression of non-small cell lung cancer (NSCLC) through upregulating AKT3 via the PI3K pathway . By using a powerful clinical molecular diagnostic assay, Matissek KJ et al. identified AKT3 gene fusion and expression is associated with treatment resistance and poor outcome in the hormone receptor-positive breast cancer . AKT3 isoform expression is found in triple-negative breast cancer. AKT3 splice variant lacking serine-472 phosphorylation site promotes apoptosis and suppresses mammary tumorigenesis . Kim M et al. also observed that AKT3 knockdown caused severe structural defects in the mitochondria and an AKT3 deficiency-induced decrease in mitochondrial respiration in A549 lung cancer cells . They concluded that AKT isoforms play distinct roles in mitochondrial function and that AKT3 is critical for proper mitochondrial respiration in human cancer cells .
 Brodbeck D, Hill MM, et al. Two splice variants of protein kinase B gamma have different regulatory capacity depending on the presence or absence of the regulatory phosphorylation site serine 472 in the carboxyl-terminal hydrophobic domain [J]. J Biol Chem 2001;276:29550-8.
 Robertson GP. Functional and therapeutic significance of Akt deregulation in malignant melanoma [J]. Cancer Metastasis Rev 2005;24:273-5.
Madhunapantula SV, Robertson GP. Targeting protein kinase-b3 (akt3) signaling in melanoma [J]. Expert Opin Ther Targets 2017;21:273-0.
 Qi YJ, Zha WJ, et al. MicroRNA-217 alleviates development of non-small cell lung cancer by inhibiting AKT3 via PI3K pathway [J]. Eur Rev Med Pharmacol Sci. 2018 Sep;22(18):5972-5979.
 Matissek KJ, Onozato ML, et al. Expressed Gene Fusions as Frequent Drivers of Poor Outcomes in Hormone Receptor-Positive Breast Cancer [J]. Cancer Discov. 2018 Mar;8(3):336-353.
 Suyama K, Yao J, et al. An Akt3 Splice Variant Lacking the Serine 472 Phosphorylation Site Promotes Apoptosis and Suppresses Mammary Tumorigenesis [J]. Cancer Res. 2018 Jan 1;78(1):103-114.
 Kim M, Kim YY, et al. Akt3 knockdown induces mitochondrial dysfunction in human cancer cells [J]. Acta Biochim Biophys Sin (Shanghai). 2016 May;48(5):447-53.