AKT3 Antibody

Datasheet
Code CSB-PA15929A0Rb
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Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. Q9Y243
Image
  • Immunoprecipitating AKT3 in mouse brain whole cell lysate
    Lane 1: Rabbit control IgG (1μg) instead of CSB-PA15929A0Rb in mouse brain whole cell lysate. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
    Lane 2: CSB-PA15929A0Rb (6μg) + Mouse brain whole cell lysate (500μg)
    Lane 3: Mouse brain whole cell lysate (10μg)

Immunogen Recombinant Human RAC-gamma serine/threonine-protein kinase protein (1-164AA)
Raised in Rabbit
Species Reactivity Human, Mouse
Tested Applications ELISA, IP; Recommended dilution: IP:1:200-1:2000
Relevance AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma) (STK-2), AKT3, PKBG
Immunogen Species Human
Protocols ELISA Protocol
Immunoprecipitation (IP) Protocol
Research Area Signal Transduction
Target Names AKT3
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.
Involvement in disease Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2 (MPPH2)
Subcellular Location Nucleus, Cytoplasm, Membrane, Peripheral membrane protein
Protein Families Protein kinase superfamily, AGC Ser/Thr protein kinase family, RAC subfamily
Tissue Specificity In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney.
Database Links

HGNC: 393

OMIM: 611223

KEGG: hsa:10000

STRING: 9606.ENSP00000263826

UniGene: Hs.498292

Pathway cAMP signaling pathway
Chemokine signaling pathway
ErbB signaling pathway
Estrogen signaling pathway
HIF-1 signaling pathway
Jak-STAT signaling pathway
MAPK signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
VEGF signaling pathway
Focal adhesion
Lipids and Inflammation in Atherogenesis
TNF signaling pathway
Apoptosis
Autophagy
Cellular senescence
Ras signaling pathway
Signaling pathways regulating pluripotency of stem cells
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Osteoclast differentiation
T cell receptor signaling pathway
Toll-like receptor signaling pathway
Adipocytokine signaling pathway
AGE-RAGE signaling pathway in diabetic complications
AMPK signaling
Apelin signaling pathway
cGMP-PKG signaling pathway
FoxO signaling pathway
Glucagon signaling pathway
Insulin signaling pathway
Oxidative Phosphorylation
Phospholipase D signaling pathway
Rap1 signaling pathway
Neurotrophin signaling pathway

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