Integrin beta-1 (ITGB1), also designated CD29 or fibronectin receptor beta subunit, is a transmembrane glycoprotein that noncovalently associates with various alpha subunits to form heterodimeric integrin receptors. These receptors mediate bidirectional signaling by connecting extracellular matrix (ECM) components like fibronectin, laminin, and collagen with intracellular cytoskeletal networks and signaling molecules. ITGB1 plays pivotal roles in cell adhesion, migration, mechanotransduction, and tissue morphogenesis through pathways including focal adhesion kinase (FAK), phosphoinositide 3-kinase (PI3K)/Akt, and mitogen-activated protein kinase (MAPK). Dysregulation of ITGB1 contributes to tumor progression, fibrosis, and inflammatory disorders via enhanced epithelial-mesenchymal transition (EMT) and ECM remodeling. Therapeutic strategies targeting ITGB1, such as inhibitory antibodies (e.g., volociximab) and peptide antagonists, are under investigation for cancers and fibrotic diseases, though clinical efficacy remains to be fully validated. Recent studies also explore its role in modulating immunotherapy resistance through ECM-mediated T-cell exclusion in tumor microenvironments.
ITGB1 Recombinant Monoclonal Antibody (CSB-RA011880A0HU)
Validated Data
Western Blot
Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, SH-SY5Y whole cell lysate, U251 whole cell lysate
All lanes: Integrin beta-1/CD29 antibody at 1.9μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 89, 88, 92 KDa
Observed band size: 130 KDa
IHC image of CSB-RA011880A0HU diluted at 1:185 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescence staining of Hela cells with CSB-RA011880A0HU at 1:61, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).
Overlay histogram showing MCF-7 cells stained with CSB-RA011880A0HU (red line) at 1:50. The cells were fixed with 70% Ethylalcohol (18h) and then permeabilized with 0.3% Triton X-100 for 2 min. The cells were then incubated in 1x PBS /10% normal goat serum to block non-specific protein-protein interactions followed by primary antibody for 1 h at 4℃. The secondary antibody used was FITC goat anti-rabbit IgG (H+L) at 1/200 dilution for 1 h at 4℃. Control antibody (green line) was used under the same conditions. Acquisition of >10,000 events was performed.
Human Integrin beta-1(ITGB1) ELISA kit (CSB-EL011880HU)
Validated Data
Code: CSB-EL011880HU
Size: 96T,5×96T,10×96T
Sensitivity: 15.6 pg/mL
Detection Range: 62.5 pg/mL-4000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
The following ITGB1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
ITGB1 Antibodies for Rattus norvegicus (Rat)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA011880LD01RA | Itgb1 Antibody, Biotin conjugated | Rat | ELISA |
CSB-PA011880LC01RA | Itgb1 Antibody, FITC conjugated | Rat | |
CSB-PA011880LA01RA | Itgb1 Antibody | Rat | ELISA |
ITGB1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA011880GA01HU | ITGB1 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA034125 | ITGB1 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA115704 | Phospho-ITGB1 (Thr789) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA192338 | Phospho-ITGB1 (Tyr795) Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA136121 | ITGB1 (Ab-789) Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA000552 | Phospho-ITGB1 (T788) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA006170 | ITGB1 Antibody | Human,Mouse,Rat | WB, ELISA |
CSB-PA011263 | Phospho-ITGB1 (Y795) Antibody | Human,Mouse,Rat | WB, ELISA |
CSB-PA011264 | Phospho-ITGB1 (T789) Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA011265 | ITGB1 Antibody | Human,Mouse,Rat | WB, ELISA |
CSB-PA011266 | ITGB1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA011267 | ITGB1 Antibody | Human,Mouse,Rat,Monkey | WB, ELISA |
CSB-PA245433 | ITGB1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA173238 | ITGB1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-RA011880A0HU | ITGB1 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC, IF, FC |
ITGB1 Antibodies for Mus musculus (Mouse)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA011880LA01MO | Itgb1 Antibody | Mouse, Human | ELISA, WB, IF |
CSB-PA011880ZA01MO | Itgb1 Antibody | Mus musculus | ELISA, WB (ensure identification of antigen) |
ITGB1 Antibodies for Sus scrofa (Pig)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA884398ZA01PI | ITGB1 Antibody | Sus scrofa | ELISA, WB (ensure identification of antigen) |
ITGB1 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP011880RA CSB-BP011880RA CSB-MP011880RA CSB-EP011880RA-B |
Recombinant Rat Integrin beta-1 (Itgb1), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP011880RA | Recombinant Rat Integrin beta-1 (Itgb1), partial | E.coli |
CSB-CF011880RA(A4) | Recombinant Rat Integrin beta-1 (Itgb1) | in vitro E.coli expression system |
ITGB1 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP011880MO CSB-BP011880MO CSB-MP011880MO CSB-EP011880MO-B |
Recombinant Mouse Integrin beta-1 (Itgb1), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP011880MO | Recombinant Mouse Integrin beta-1 (Itgb1), partial | E.coli |
CSB-CF011880MO(A4) | Recombinant Mouse Integrin beta-1 (Itgb1) | in vitro E.coli expression system |
ITGB1 Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-YP884398PI CSB-BP884398PI CSB-MP884398PI CSB-EP884398PI-B |
Recombinant Pig Integrin beta-1 (ITGB1), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP884398PI | Recombinant Pig Integrin beta-1 (ITGB1), partial | E.coli |
ITGB1 Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Code | Product Name | Source |
---|---|---|
CSB-CF725405PYX | Recombinant Pongo abelii Integrin beta-1 (ITGB1) | in vitro E.coli expression system |
CSB-YP725405PYX1 CSB-EP725405PYX1 CSB-BP725405PYX1 CSB-MP725405PYX1 CSB-EP725405PYX1-B |
Recombinant Pongo abelii Integrin beta-1 (ITGB1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGB1 Proteins for Felis catus (Cat) (Felis silvestris catus)
Code | Product Name | Source |
---|---|---|
CSB-CF011880CA | Recombinant Cat Integrin beta-1 (ITGB1) | in vitro E.coli expression system |
CSB-YP011880CA1 CSB-EP011880CA1 CSB-BP011880CA1 CSB-MP011880CA1 CSB-EP011880CA1-B |
Recombinant Cat Integrin beta-1 (ITGB1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGB1 Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-CF011880BO | Recombinant Bovine Integrin beta-1 (ITGB1) | in vitro E.coli expression system |
CSB-YP011880BO1 CSB-EP011880BO1 CSB-BP011880BO1 CSB-MP011880BO1 CSB-EP011880BO1-B |
Recombinant Bovine Integrin beta-1 (ITGB1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGB1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-CF011880HU | Recombinant Human Integrin beta-1 (ITGB1) | in vitro E.coli expression system |
CSB-YP011880HU1 CSB-EP011880HU1 CSB-BP011880HU1 CSB-MP011880HU1 CSB-EP011880HU1-B |
Recombinant Human Integrin beta-1 (ITGB1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGB1 Proteins for Ovis aries (Sheep)
Code | Product Name | Source |
---|---|---|
CSB-CF011880SH | Recombinant Sheep Integrin beta-1 (ITGB1) | in vitro E.coli expression system |
CSB-YP011880SH1 CSB-EP011880SH1 CSB-BP011880SH1 CSB-MP011880SH1 CSB-EP011880SH1-B |
Recombinant Sheep Integrin beta-1 (ITGB1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGB1 Proteins for Camelus bactrianus (Bactrian camel)
Code | Product Name | Source |
---|---|---|
CSB-CF011880CVZ | Recombinant Camelus bactrianus Integrin beta-1 (ITGB1) | in vitro E.coli expression system |
CSB-YP011880CVZ1 CSB-EP011880CVZ1 CSB-BP011880CVZ1 CSB-MP011880CVZ1 CSB-EP011880CVZ1-B |
Recombinant Camelus bactrianus Integrin beta-1 (ITGB1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGB1 Proteins for Gallus gallus (Chicken)
Code | Product Name | Source |
---|---|---|
CSB-CF011880CH | Recombinant Chicken Integrin beta-1 (ITGB1) | in vitro E.coli expression system |
CSB-YP011880CH1 CSB-EP011880CH1 CSB-BP011880CH1 CSB-MP011880CH1 CSB-EP011880CH1-B |
Recombinant Chicken Integrin beta-1 (ITGB1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGB1 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL011880HU | Human Integrin beta-1(ITGB1) ELISA kit | serum, plasma, tissue homogenates | 15.6 pg/mL |